ID   RELL2_RAT               Reviewed;         302 AA.
AC   Q5FVJ4;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=RELT-like protein 2;
GN   Name=Rell2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Induces activation of MAPK14/p38 cascade, when overexpressed.
CC       Induces apoptosis, when overexpressed. {ECO:0000250|UniProtKB:Q8NC24}.
CC   -!- SUBUNIT: Interacts with RELT, RELL1, OXSR1, PLSCR1 AND TRAF2.
CC       {ECO:0000250|UniProtKB:Q8NC24}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8NC24};
CC       Single-pass membrane protein {ECO:0000250|UniProtKB:Q8NC24}.
CC   -!- SIMILARITY: Belongs to the RELT family. {ECO:0000305}.
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DR   EMBL; BC089946; AAH89946.1; -; mRNA.
DR   RefSeq; NP_001014171.1; NM_001014149.1.
DR   AlphaFoldDB; Q5FVJ4; -.
DR   STRING; 10116.ENSRNOP00000026526; -.
DR   SwissPalm; Q5FVJ4; -.
DR   PaxDb; Q5FVJ4; -.
DR   PRIDE; Q5FVJ4; -.
DR   Ensembl; ENSRNOT00000026526; ENSRNOP00000026526; ENSRNOG00000019575.
DR   GeneID; 361313; -.
DR   KEGG; rno:361313; -.
DR   UCSC; RGD:1305276; rat.
DR   CTD; 285613; -.
DR   RGD; 1305276; Rell2.
DR   eggNOG; ENOG502RZW4; Eukaryota.
DR   GeneTree; ENSGT00940000160541; -.
DR   HOGENOM; CLU_074130_0_0_1; -.
DR   InParanoid; Q5FVJ4; -.
DR   OMA; RIVQCII; -.
DR   OrthoDB; 1464869at2759; -.
DR   PhylomeDB; Q5FVJ4; -.
DR   TreeFam; TF332339; -.
DR   PRO; PR:Q5FVJ4; -.
DR   Proteomes; UP000002494; Chromosome 18.
DR   Bgee; ENSRNOG00000019575; Expressed in cerebellum and 11 other tissues.
DR   Genevisible; Q5FVJ4; RN.
DR   GO; GO:0005604; C:basement membrane; ISO:RGD.
DR   GO; GO:0031012; C:extracellular matrix; ISO:RGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005518; F:collagen binding; ISO:RGD.
DR   GO; GO:0010811; P:positive regulation of cell-substrate adhesion; ISO:RGD.
DR   GO; GO:1900745; P:positive regulation of p38MAPK cascade; ISS:UniProtKB.
DR   InterPro; IPR042313; RELL2.
DR   InterPro; IPR022248; TNF_rcpt_RELT.
DR   PANTHER; PTHR31481; PTHR31481; 1.
DR   Pfam; PF12606; RELT; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..302
FT                   /note="RELT-like protein 2"
FT                   /id="PRO_0000249847"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          47..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          135..164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          177..212
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          247..302
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        251..295
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         52
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BRJ3"
SQ   SEQUENCE   302 AA;  32134 MW;  B98DBCD22774C4E3 CRC64;
     MSEPQPGLEP PQHGLYMLFL LVLVFFLMGL VGFMICHVLK KKGYRCRTSR GSEPDDAQLQ
     PPEDDDVNED TVERIVRCII QNEANAEALK EMLGDSEGEG TVQLSSVDAT SSLQDGAPSH
     HHTVHLGSAA PCIHCSRSKR PPLVRQGRSK EGKGRPRPGE TTVFSVGRFR VTHIEKRYGL
     HEHRDGSPTD RSWGSGGGQE PGVSQVAGGQ PRTGTAAIER LLPEPPPSQA AATHPVQNGR
     LKDASLVPCT LEGTPGTSAE LNVGTRGTGP SPGLPSQEAN GQPTKLDTSG QQDSLPPEAG
     GM