ID   RELX_BALED              Reviewed;          54 AA.
AC   P11185;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 2.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Relaxin;
DE   Contains:
DE     RecName: Full=Relaxin B chain;
DE   Contains:
DE     RecName: Full=Relaxin A chain;
OS   Balaenoptera edeni (Pigmy Bryde's whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC   Balaenopteridae; Balaenoptera.
OX   NCBI_TaxID=9769;
RN   [1]
RP   PROTEIN SEQUENCE, AND PYROGLUTAMATE FORMATION AT GLN-1.
RX   PubMed=2910872; DOI=10.1016/s0021-9258(19)85033-0;
RA   Schwabe C., Bullesbach E.E., Heyn H., Yoshioka M.;
RT   "Cetacean relaxin. Isolation and sequence of relaxins from Balaenoptera
RT   acutorostrata and Balaenoptera edeni.";
RL   J. Biol. Chem. 264:940-943(1989).
CC   -!- FUNCTION: Relaxin is an ovarian hormone that acts with estrogen to
CC       produce dilatation of the birth canal in many mammals.
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   PIR; A32201; A32201.
DR   AlphaFoldDB; P11185; -.
DR   SMR; P11185; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   Pfam; PF00049; Insulin; 1.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Hormone; Pyrrolidone carboxylic acid; Secreted.
FT   PEPTIDE         1..32
FT                   /note="Relaxin B chain"
FT                   /id="PRO_0000016065"
FT   PEPTIDE         33..54
FT                   /note="Relaxin A chain"
FT                   /id="PRO_0000016066"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:2910872"
FT   DISULFID        10..41
FT                   /note="Interchain (between B and A chains)"
FT   DISULFID        22..54
FT                   /note="Interchain (between B and A chains)"
FT   DISULFID        40..45
FT   NON_CONS        32..33
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   54 AA;  6071 MW;  705E35F895133408 CRC64;
     QSTNDLIKAC GRELVRLWVE ICGSVSWGRT ALRMTLSEKC CQVGCIRKDI ARLC