ID   RELX_CARTA              Reviewed;          44 AA.
AC   P01349;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 2.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Relaxin;
DE   Contains:
DE     RecName: Full=Relaxin B chain;
DE   Contains:
DE     RecName: Full=Relaxin A chain;
DE   Flags: Fragments;
OS   Carcharias taurus (Sand tiger shark) (Eugomphodus taurus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Galeomorphii; Galeoidea; Lamniformes; Odontaspididae;
OC   Carcharias.
OX   NCBI_TaxID=30501;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=7274472; DOI=10.1016/0014-5793(81)80760-0;
RA   Gowan L.K., Reinig J.W., Schwabe C., Bedarkar S., Blundell T.L.;
RT   "On the primary and tertiary structure of relaxin from the sand tiger shark
RT   (Odontaspis taurus).";
RL   FEBS Lett. 129:80-82(1981).
RN   [2]
RP   SEQUENCE REVISION TO 20, AND PYROGLUTAMATE FORMATION AT GLN-1.
RX   PubMed=3780747; DOI=10.1111/j.1432-1033.1986.tb10452.x;
RA   Bullesbach E.E., Gowan L.K., Schwabe C., Steinetz B.G., O'Byrne E.,
RA   Callard I.P.;
RT   "Isolation, purification, and the sequence of relaxin from spiny dogfish
RT   (Squalus acanthias).";
RL   Eur. J. Biochem. 161:335-341(1986).
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   PIR; A01616; RXRKOT.
DR   AlphaFoldDB; P01349; -.
DR   SMR; P01349; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR003235; Nem_insulin-like_b-type.
DR   Pfam; PF03488; Ins_beta; 1.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone;
KW   Pyrrolidone carboxylic acid; Secreted.
FT   PEPTIDE         1..20
FT                   /note="Relaxin B chain"
FT                   /id="PRO_0000016121"
FT   PEPTIDE         21..44
FT                   /note="Relaxin A chain"
FT                   /id="PRO_0000016122"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:3780747"
FT   DISULFID        3..31
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        15..44
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        30..35
FT                   /evidence="ECO:0000250"
FT   NON_CONS        1..2
FT                   /evidence="ECO:0000305"
FT   NON_CONS        20..21
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   44 AA;  4730 MW;  6122F6604C660607 CRC64;
     QLCGRGFIRA IIFACGGSRW ATSPAMSIKC CIYGCTKKDI SVLC