ID   RELX_LEUER              Reviewed;          64 AA.
AC   P11952;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Relaxin;
DE   Contains:
DE     RecName: Full=Relaxin B chain;
DE   Contains:
DE     RecName: Full=Relaxin A chain;
OS   Leucoraja erinacea (Little skate) (Raja erinacea).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Batoidea; Rajiformes; Rajidae; Leucoraja.
OX   NCBI_TaxID=7782;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Ovary;
RX   PubMed=3827922; DOI=10.1016/0006-291x(87)90661-9;
RA   Bullesbach E.E., Schwabe C., Callard I.P.;
RT   "Relaxin from an oviparous species, the skate (Raja erinacea).";
RL   Biochem. Biophys. Res. Commun. 143:273-280(1987).
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   PIR; A29543; A29543.
DR   AlphaFoldDB; P11952; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Secreted.
FT   PEPTIDE         1..40
FT                   /note="Relaxin B chain"
FT                   /id="PRO_0000016123"
FT   PEPTIDE         41..64
FT                   /note="Relaxin A chain"
FT                   /id="PRO_0000016124"
FT   DISULFID        11..51
FT                   /note="Interchain (between B and A chains)"
FT   DISULFID        23..64
FT                   /note="Interchain (between B and A chains)"
FT   DISULFID        50..55
FT   NON_CONS        40..41
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   64 AA;  7499 MW;  E7AC62B8BA81F49D CRC64;
     RPNWEERSRL CGRDLIRAFI YLCGGTRWTR LPNFGNYPIM EEKMGFAKKC CAIGCSTEDF
     RMVC