ID   RELX_MACMU              Reviewed;         185 AA.
AC   P19884;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Prorelaxin;
DE   Contains:
DE     RecName: Full=Relaxin B chain;
DE   Contains:
DE     RecName: Full=Relaxin A chain;
DE   Flags: Precursor;
GN   Name=RLN;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=2590381; DOI=10.1677/jme.0.0030169;
RA   Crawford R.J., Hammond V.E., Roche P.J., Johnston P.D., Tregear G.W.;
RT   "Structure of rhesus monkey relaxin predicted by analysis of the single-
RT   copy rhesus monkey relaxin gene.";
RL   J. Mol. Endocrinol. 3:169-174(1989).
CC   -!- FUNCTION: Relaxin is an ovarian hormone that acts with estrogen to
CC       produce dilatation of the birth canal in many mammals. May be involved
CC       in remodeling of connective tissues during pregnancy, promoting growth
CC       of pubic ligaments and ripening of the cervix.
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   PIR; A34936; A34936.
DR   AlphaFoldDB; P19884; -.
DR   SMR; P19884; -.
DR   InParanoid; P19884; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022421; Relaxin.
DR   Pfam; PF00049; Insulin; 1.
DR   PRINTS; PR02004; RELAXIN.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         25..53
FT                   /note="Relaxin B chain"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000016097"
FT   PROPEP          56..157
FT                   /note="Connecting peptide"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000016098"
FT   PEPTIDE         162..185
FT                   /note="Relaxin A chain"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000016099"
FT   DISULFID        35..172
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        47..185
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        171..176
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   185 AA;  20895 MW;  7E3C5D21B57E185C CRC64;
     MPRLFLFHLL GVCLLLNQFS RAVAAKWMDD VIKACGRELV RAQIAICGKS TLGKRSLNQE
     DAPLKPRPAA EIVPSLINQD TETINMMSEF VANLPQELKL TLSERQPALS ELQQHVPVLK
     DSNLSFEEFK KIIRKRQSEA TDSSPSELRS LGLDTHSRRK RQLYMTLSNK CCHIGCTKKS
     LAKFC