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RELX_PIG
ID   RELX_PIG                Reviewed;         182 AA.
AC   P01348;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   25-MAY-2022, entry version 130.
DE   RecName: Full=Prorelaxin;
DE   Contains:
DE     RecName: Full=Relaxin B chain;
DE   Contains:
DE     RecName: Full=Relaxin A chain;
DE   Flags: Precursor;
GN   Name=RLN;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=6897721; DOI=10.1089/dna.1.1982.1.155;
RA   Haley J., Hudson P., Scanlon D., John M., Cronk M., Shine J., Tregear G.,
RA   Niall H.;
RT   "Porcine relaxin: molecular cloning and cDNA structure.";
RL   DNA 1:155-162(1982).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2442155; DOI=10.1016/s0021-9258(18)45299-4;
RA   Haley J., Crawford R., Hudson P., Scanlon D., Tregear G., Shine J.,
RA   Niall H.;
RT   "Porcine relaxin. Gene structure and expression.";
RL   J. Biol. Chem. 262:11940-11946(1987).
RN   [3]
RP   PRELIMINARY PROTEIN SEQUENCE OF 25-54 AND 161-182.
RX   PubMed=876374; DOI=10.1038/267544a0;
RA   James R., Niall H., Kwok S., Bryant-Greenwood G.;
RT   "Primary structure of porcine relaxin: homology with insulin and related
RT   growth factors.";
RL   Nature 267:544-546(1977).
RN   [4]
RP   PROTEIN SEQUENCE OF 25-51.
RX   PubMed=851452; DOI=10.1016/0006-291x(77)91070-1;
RA   Schwabe C., McDonald J.K., Steinetz B.G.;
RT   "Primary structure of the B-chain of porcine relaxin.";
RL   Biochem. Biophys. Res. Commun. 75:503-510(1977).
RN   [5]
RP   PYROGLUTAMATE FORMATION AT GLN-25.
RX   PubMed=843375; DOI=10.1016/0006-291x(77)90612-x;
RA   Schwabe C., McDonald J.K.;
RT   "Demonstration of a pyroglutamyl residue at the N-terminus of the B-chain
RT   of porcine relaxin.";
RL   Biochem. Biophys. Res. Commun. 74:1501-1504(1977).
RN   [6]
RP   PROTEIN SEQUENCE OF 161-182.
RX   PubMed=938497; DOI=10.1016/0006-291x(76)91059-7;
RA   Schwabe C., McDonald J.K., Steinetz B.G.;
RT   "Primary structure of the A chain of porcine relaxin.";
RL   Biochem. Biophys. Res. Commun. 70:397-405(1976).
RN   [7]
RP   DISULFIDE BONDS.
RX   PubMed=887933; DOI=10.1126/science.887933;
RA   Schwabe C., McDonald J.K.;
RT   "Relaxin: a disulfide homolog of insulin.";
RL   Science 197:914-915(1977).
RN   [8]
RP   3D-STRUCTURE MODELING.
RX   PubMed=622170; DOI=10.1038/271278a0;
RA   Isaacs N.W., James R., Niall H., Bryant-Greenwood G., Dodson G.G.,
RA   Evans A., North A.C.T.;
RT   "Relaxin and its structural relationship to insulin.";
RL   Nature 271:278-281(1978).
CC   -!- FUNCTION: Relaxin is an ovarian hormone that acts with estrogen to
CC       produce dilatation of the birth canal in many mammals.
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   EMBL; K01088; AAA31114.1; -; mRNA.
DR   EMBL; J02792; AAA31115.1; -; Genomic_DNA.
DR   PIR; A90934; RXPG.
DR   RefSeq; NP_999037.1; NM_213872.1.
DR   AlphaFoldDB; P01348; -.
DR   SMR; P01348; -.
DR   MINT; P01348; -.
DR   STRING; 9823.ENSSSCP00000005607; -.
DR   PaxDb; P01348; -.
DR   PRIDE; P01348; -.
DR   GeneID; 396891; -.
DR   KEGG; ssc:396891; -.
DR   CTD; 6019; -.
DR   eggNOG; ENOG502TH8D; Eukaryota.
DR   InParanoid; P01348; -.
DR   OrthoDB; 1331287at2759; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0001832; P:blastocyst growth; IDA:CACAO.
DR   GO; GO:0030317; P:flagellated sperm motility; IDA:CACAO.
DR   GO; GO:0001556; P:oocyte maturation; IDA:CACAO.
DR   GO; GO:2000344; P:positive regulation of acrosome reaction; IDA:CACAO.
DR   GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IDA:CACAO.
DR   GO; GO:0046326; P:positive regulation of glucose import; IDA:CACAO.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022421; Relaxin.
DR   Pfam; PF00049; Insulin; 1.
DR   PRINTS; PR02004; RELAXIN.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Hormone; Pyrrolidone carboxylic acid; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000269|PubMed:851452"
FT   PEPTIDE         25..56
FT                   /note="Relaxin B chain"
FT                   /evidence="ECO:0000269|PubMed:6897721"
FT                   /id="PRO_0000016112"
FT   PROPEP          57..154
FT                   /note="Connecting peptide"
FT                   /id="PRO_0000016113"
FT   PROPEP          159..160
FT                   /evidence="ECO:0000269|PubMed:938497"
FT                   /id="PRO_0000016114"
FT   PEPTIDE         161..182
FT                   /note="Relaxin A chain"
FT                   /evidence="ECO:0000269|PubMed:6897721"
FT                   /id="PRO_0000016115"
FT   MOD_RES         25
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:843375,
FT                   ECO:0000269|PubMed:876374"
FT   DISULFID        34..169
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000269|PubMed:887933"
FT   DISULFID        46..182
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000269|PubMed:887933"
FT   DISULFID        168..173
FT                   /evidence="ECO:0000269|PubMed:887933"
FT   CONFLICT        47
FT                   /note="G -> GVWS (in Ref. 4; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        51..54
FT                   /note="WGRT -> TWGR (in Ref. 3; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        116
FT                   /note="S -> L (in Ref. 2; AAA31115)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        170
FT                   /note="Q -> E (in Ref. 6; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   182 AA;  20818 MW;  20736EB089F13AB4 CRC64;
     MPRLFSYLLG VWLLLSQLPR EIPGQSTNDF IKACGRELVR LWVEICGSVS WGRTALSLEE
     PQLETGPPAE TMPSSITKDA EILKMMLEFV PNLPQELKAT LSERQPSLRE LQQSASKDSN
     LNFEEFKKII LNRQNEAEDK SLLELKNLGL DKHSRKKRLF RMTLSEKCCQ VGCIRKDIAR
     LC
 
 
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