ID   RELX_SQUAC              Reviewed;          54 AA.
AC   P11953;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 2.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Relaxin;
DE   Contains:
DE     RecName: Full=Relaxin B chain;
DE   Contains:
DE     RecName: Full=Relaxin A chain;
OS   Squalus acanthias (Spiny dogfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Squalomorphii; Squaliformes; Squalidae; Squalus.
OX   NCBI_TaxID=7797;
RN   [1]
RP   PROTEIN SEQUENCE, AND PYROGLUTAMATE FORMATION AT GLN-1.
RC   TISSUE=Ovary;
RX   PubMed=3780747; DOI=10.1111/j.1432-1033.1986.tb10452.x;
RA   Bullesbach E.E., Gowan L.K., Schwabe C., Steinetz B.G., O'Byrne E.,
RA   Callard I.P.;
RT   "Isolation, purification, and the sequence of relaxin from spiny dogfish
RT   (Squalus acanthias).";
RL   Eur. J. Biochem. 161:335-341(1986).
CC   -!- FUNCTION: The function of relaxin in an oviparous species is not yet
CC       known.
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   PIR; B26463; A26463.
DR   AlphaFoldDB; P11953; -.
DR   SMR; P11953; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   InterPro; IPR003235; Nem_insulin-like_b-type.
DR   Pfam; PF03488; Ins_beta; 1.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone;
KW   Pyrrolidone carboxylic acid; Secreted.
FT   PEPTIDE         1..30
FT                   /note="Relaxin B chain"
FT                   /id="PRO_0000016125"
FT   PEPTIDE         31..54
FT                   /note="Relaxin A chain"
FT                   /id="PRO_0000016126"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:3780747"
FT   DISULFID        13..41
FT                   /note="Interchain (between B and A chains)"
FT   DISULFID        25..54
FT                   /note="Interchain (between B and A chains)"
FT   DISULFID        40..45
FT   NON_CONS        30..31
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   54 AA;  5910 MW;  1B7206773AD32A5B CRC64;
     QSFKNAEPGI KLCGREFIRA VIYTCGGSRW EGSPGMSSKC CTYGCTRKDI SILC