ID   REL_AVIRE               Reviewed;         503 AA.
AC   P01126;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   02-JUN-2021, entry version 125.
DE   RecName: Full=Transforming protein rel polyprotein;
DE   AltName: Full=p58 V-rel;
DE   Contains:
DE     RecName: Full=Env polyprotein N-terminal;
DE   Contains:
DE     RecName: Full=Transforming protein rel;
DE   Contains:
DE     RecName: Full=Env polyprotein C-terminal;
GN   Name=V-REL;
OS   Avian reticuloendotheliosis virus.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Gammaretrovirus.
OX   NCBI_TaxID=11636;
OH   NCBI_TaxID=8976; Galliformes.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=6312449; DOI=10.1073/pnas.80.20.6229;
RA   Stephens R.M., Rice N.R., Hiebsch R.R., Bose H.R. Jr., Gilden R.V.;
RT   "Nucleotide sequence of v-rel: the oncogene of reticuloendotheliosis
RT   virus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 80:6229-6233(1983).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=T;
RX   PubMed=6090694; DOI=10.1128/jvi.52.1.172-182.1984;
RA   Wilhelmsen K.C., Eggleton K., Temin H.M.;
RT   "Nucleic acid sequences of the oncogene v-rel in reticuloendotheliosis
RT   virus strain T and its cellular homolog, the proto-oncogene c-rel.";
RL   J. Virol. 52:172-182(1984).
CC   -!- FUNCTION: This transforming protein appears to have a protein-kinase
CC       activity.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm.
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DR   EMBL; X02759; CAA26534.1; -; Genomic_RNA.
DR   PIR; A93974; VCVDA.
DR   SMR; P01126; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01177; IPT_NFkappaB; 1.
DR   CDD; cd07933; RHD-n_c-Rel; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 2.60.40.340; -; 1.
DR   InterPro; IPR030505; c-Rel.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   InterPro; IPR033926; IPT_NFkappaB.
DR   InterPro; IPR000451; NFkB/Dor.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR042845; RHD-n_c-Rel.
DR   InterPro; IPR030492; RHD_CS.
DR   InterPro; IPR032397; RHD_dimer.
DR   InterPro; IPR011539; RHD_DNA_bind_dom.
DR   InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR   PANTHER; PTHR24169; PTHR24169; 1.
DR   PANTHER; PTHR24169:SF4; PTHR24169:SF4; 1.
DR   Pfam; PF16179; RHD_dimer; 1.
DR   Pfam; PF00554; RHD_DNA_bind; 1.
DR   PRINTS; PR00057; NFKBTNSCPFCT.
DR   SMART; SM00429; IPT; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS01204; REL_1; 1.
DR   PROSITE; PS50254; REL_2; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Oncogene; Phosphoprotein.
FT   CHAIN           1..12
FT                   /note="Env polyprotein N-terminal"
FT                   /id="PRO_0000030307"
FT   CHAIN           13..484
FT                   /note="Transforming protein rel"
FT                   /id="PRO_0000030308"
FT   CHAIN           485..503
FT                   /note="Env polyprotein C-terminal"
FT                   /id="PRO_0000030309"
FT   DOMAIN          16..305
FT                   /note="RHD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00265"
FT   REGION          286..306
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          318..342
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           298..303
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         275
FT                   /note="Phosphoserine; by host PKA"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   503 AA;  55910 MW;  3F407A25C4FC0AD1 CRC64;
     MDFLTNLRFT EGISEPYIEI FEQPRQRGTR FRYKCEGRSA GSIPGEHSTD NNKTFPSIQI
     LNYFGKVKIR TTLVTKNEPY KPHPHDLVGK GCRDGYYEAE FGPERQVLSF QNLGIQCVKK
     KDLKESISLR ISKKINPFNV PEEQLHNIDE YDLNVVRLCF QAFLPDEHGN YTLALPPLIS
     NPIYDNRAPN TAELRICRVN KNCGSVKGGD EIFLLCDKVQ KDDIEVRFVL GNWEAKGSFS
     QADVHRQVAI VFRTPPFLGD ITEPITVKMQ LRRPSDQAVS EPVDFRYLPD EEDPSGNKAK
     RQRSTLAWQK PIQDCGSAVT ERPKAAPIPT VNPEGKLKKE PNMFSPTLML PGLGTLSSSQ
     MYPACSQMPT QPAQLGPGKQ DTLHSCWQQL YSPSPSASSL LSLHSHSSFT AEVPQPGAQG
     SSSLPAYNPL NWPDEKNSSF YRNFGNTHGM GAALVSAAGM QSVSSSSIVQ GTHQASATTA
     SIMTMPRTPG EVPFLRQQVG YRS