REL_HUMAN
ID REL_HUMAN Reviewed; 619 AA.
AC Q04864; Q17RU2; Q2PNZ7; Q6LDY0;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 201.
DE RecName: Full=Proto-oncogene c-Rel;
GN Name=REL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=2666912;
RA Brownell E., Mittereder N., Rice N.R.;
RT "A human rel proto-oncogene cDNA containing an Alu fragment as a potential
RT coding exon.";
RL Oncogene 4:935-942(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG NHLBI resequencing and genotyping service (RS&G);
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 180-284.
RX PubMed=3016517; DOI=10.1128/mcb.5.10.2826-2831.1985;
RA Brownell E., O'Brien S.J., Nash W.G., Rice N.R.;
RT "Genetic characterization of human c-rel sequences.";
RL Mol. Cell. Biol. 5:2826-2831(1985).
RN [6]
RP IDENTIFICATION IN THE NF-KAPPA-B P65-C-REL COMPLEX.
RX PubMed=1740106; DOI=10.1002/j.1460-2075.1992.tb05043.x;
RA Hansen S.K., Nerlov C., Zabel U., Verde P., Johnsen M., Baeuerle P.A.,
RA Blasi F.;
RT "A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a
RT DNA element involved in the phorbol ester induction of the human urokinase
RT gene.";
RL EMBO J. 11:205-213(1992).
RN [7]
RP IDENTIFICATION IN THE NF-KAPPA-B P50-C-REL COMPLEX, IDENTIFICATION IN THE
RP NF-KAPPA-B P52-C-REL COMPLEX, AND IDENTIFICATION IN THE NF-KAPPA-B
RP P65-C-REL COMPLEX.
RX PubMed=8152812;
RA Beg A.A., Baldwin A.S. Jr.;
RT "Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor
RT necrosis factor.";
RL Oncogene 9:1487-1492(1994).
RN [8]
RP IDENTIFICATION IN THE NF-KAPPA-B P65-C-REL COMPLEX.
RX PubMed=9056676;
RA Aoudjit F., Brochu N., Belanger B., Stratowa C., Hiscott J., Audette M.;
RT "Regulation of intercellular adhesion molecule-1 gene by tumor necrosis
RT factor-alpha is mediated by the nuclear factor-kappaB heterodimers p65/p65
RT and p65/c-Rel in the absence of p50.";
RL Cell Growth Differ. 8:335-342(1997).
RN [9]
RP INTERACTION WITH NFKBIE.
RX PubMed=9315679; DOI=10.1128/mcb.17.10.6184;
RA Li Z., Nabel G.J.;
RT "A new member of the IkappaB protein family, IkappaB epsilon, inhibits RelA
RT (p65)-mediated NF-kappaB transcription.";
RL Mol. Cell. Biol. 17:6184-6190(1997).
RN [10]
RP PHOSPHORYLATION AT SER-503.
RX PubMed=10823840; DOI=10.1074/jbc.m909396199;
RA Martin A.G., Fresno M.;
RT "Tumor necrosis factor-alpha activation of NF-kappa B requires the
RT phosphorylation of Ser-471 in the transactivation domain of c-Rel.";
RL J. Biol. Chem. 275:24383-24391(2000).
RN [11]
RP IDENTIFICATION IN THE NF-KAPPA-B P50-C-REL COMPLEX.
RX PubMed=15102766; DOI=10.1128/iai.72.5.2582-2589.2004;
RA Guizani-Tabbane L., Ben-Aissa K., Belghith M., Sassi A., Dellagi K.;
RT "Leishmania major amastigotes induce p50/c-Rel NF-kappa B transcription
RT factor in human macrophages: involvement in cytokine synthesis.";
RL Infect. Immun. 72:2582-2589(2004).
RN [12]
RP INTERACTION WITH NKIRAS1.
RX PubMed=15024091; DOI=10.1128/mcb.24.7.3048-3056.2004;
RA Chen Y., Vallee S., Wu J., Vu D., Sondek J., Ghosh G.;
RT "Inhibition of NF-kappaB activity by IkappaBbeta in association with
RT kappaB-Ras.";
RL Mol. Cell. Biol. 24:3048-3056(2004).
RN [13]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: Proto-oncogene that may play a role in differentiation and
CC lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which
CC is present in almost all cell types and is involved in many biological
CC processed such as inflammation, immunity, differentiation, cell growth,
CC tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric
CC complex formed by the Rel-like domain-containing proteins RELA/p65,
CC RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at
CC kappa-B sites in the DNA of their target genes and the individual
CC dimers have distinct preferences for different kappa-B sites that they
CC can bind with distinguishable affinity and specificity. Different dimer
CC combinations act as transcriptional activators or repressors,
CC respectively. NF-kappa-B is controlled by various mechanisms of post-
CC translational modification and subcellular compartmentalization as well
CC as by interactions with other cofactors or corepressors. NF-kappa-B
CC complexes are held in the cytoplasm in an inactive state complexed with
CC members of the NF-kappa-B inhibitor (I-kappa-B) family. In a
CC conventional activation pathway, I-kappa-B is phosphorylated by I-
CC kappa-B kinases (IKKs) in response to different activators,
CC subsequently degraded thus liberating the active NF-kappa-B complex
CC which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-
CC c-Rel is a transcriptional activator.
CC -!- SUBUNIT: Component of the NF-kappa-B p65-c-Rel complex. Component of
CC the NF-kappa-B p50-c-Rel complex. Component of the NF-kappa-B p52-c-Rel
CC complex. Homodimer; component of the NF-kappa-B c-Rel-c-Rel complex (By
CC similarity). Interacts with NKIRAS1. Interacts with NFKBIB (By
CC similarity). Interacts with NFKBIE. {ECO:0000250,
CC ECO:0000269|PubMed:15024091, ECO:0000269|PubMed:15102766,
CC ECO:0000269|PubMed:1740106, ECO:0000269|PubMed:8152812,
CC ECO:0000269|PubMed:9056676, ECO:0000269|PubMed:9315679}.
CC -!- INTERACTION:
CC Q04864; Q9NQ94: A1CF; NbExp=3; IntAct=EBI-307352, EBI-2809489;
CC Q04864; O14734: ACOT8; NbExp=3; IntAct=EBI-307352, EBI-1237371;
CC Q04864; Q9NRZ5: AGPAT4; NbExp=3; IntAct=EBI-307352, EBI-1754287;
CC Q04864; P09917: ALOX5; NbExp=3; IntAct=EBI-307352, EBI-79934;
CC Q04864; O95376: ARIH2; NbExp=3; IntAct=EBI-307352, EBI-711158;
CC Q04864; Q8TDY4: ASAP3; NbExp=3; IntAct=EBI-307352, EBI-2609717;
CC Q04864; Q7Z3C6: ATG9A; NbExp=3; IntAct=EBI-307352, EBI-727146;
CC Q04864; Q8N5M1: ATPAF2; NbExp=3; IntAct=EBI-307352, EBI-1166928;
CC Q04864; P54253: ATXN1; NbExp=3; IntAct=EBI-307352, EBI-930964;
CC Q04864; Q9NY43: BARHL2; NbExp=3; IntAct=EBI-307352, EBI-10316571;
CC Q04864; P55957: BID; NbExp=3; IntAct=EBI-307352, EBI-519672;
CC Q04864; P55957-2: BID; NbExp=3; IntAct=EBI-307352, EBI-10215147;
CC Q04864; Q96LC9: BMF; NbExp=3; IntAct=EBI-307352, EBI-3919268;
CC Q04864; Q9H3H3: C11orf68; NbExp=3; IntAct=EBI-307352, EBI-721765;
CC Q04864; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-307352, EBI-8643161;
CC Q04864; Q96LT7: C9orf72; NbExp=3; IntAct=EBI-307352, EBI-2961725;
CC Q04864; Q9NP86: CABP5; NbExp=3; IntAct=EBI-307352, EBI-10311131;
CC Q04864; F6RF56: CCNJL; NbExp=3; IntAct=EBI-307352, EBI-10177725;
CC Q04864; P42773: CDKN2C; NbExp=4; IntAct=EBI-307352, EBI-711290;
CC Q04864; A8MT69: CENPX; NbExp=3; IntAct=EBI-307352, EBI-5529694;
CC Q04864; Q96LK0: CEP19; NbExp=3; IntAct=EBI-307352, EBI-741885;
CC Q04864; Q9UFW8: CGGBP1; NbExp=4; IntAct=EBI-307352, EBI-723153;
CC Q04864; Q13111: CHAF1A; NbExp=3; IntAct=EBI-307352, EBI-1020839;
CC Q04864; Q9Y6H1: CHCHD2; NbExp=3; IntAct=EBI-307352, EBI-2321769;
CC Q04864; Q96Q77: CIB3; NbExp=3; IntAct=EBI-307352, EBI-10292696;
CC Q04864; Q9BW66: CINP; NbExp=3; IntAct=EBI-307352, EBI-739784;
CC Q04864; P61024: CKS1B; NbExp=3; IntAct=EBI-307352, EBI-456371;
CC Q04864; Q9P218-2: COL20A1; NbExp=3; IntAct=EBI-307352, EBI-10318410;
CC Q04864; P27658: COL8A1; NbExp=3; IntAct=EBI-307352, EBI-747133;
CC Q04864; Q8N668: COMMD1; NbExp=3; IntAct=EBI-307352, EBI-1550112;
CC Q04864; Q96FN4: CPNE2; NbExp=3; IntAct=EBI-307352, EBI-7097057;
CC Q04864; Q10570: CPSF1; NbExp=3; IntAct=EBI-307352, EBI-347859;
CC Q04864; Q9NSA3: CTNNBIP1; NbExp=3; IntAct=EBI-307352, EBI-747082;
CC Q04864; P49366: DHPS; NbExp=3; IntAct=EBI-307352, EBI-741925;
CC Q04864; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-307352, EBI-9679045;
CC Q04864; P04053: DNTT; NbExp=3; IntAct=EBI-307352, EBI-1220259;
CC Q04864; Q9Y6G9: DYNC1LI1; NbExp=4; IntAct=EBI-307352, EBI-2556107;
CC Q04864; Q5JVL4: EFHC1; NbExp=7; IntAct=EBI-307352, EBI-743105;
CC Q04864; Q9H6Z9: EGLN3; NbExp=4; IntAct=EBI-307352, EBI-1175354;
CC Q04864; Q14152: EIF3A; NbExp=3; IntAct=EBI-307352, EBI-366617;
CC Q04864; O15371: EIF3D; NbExp=3; IntAct=EBI-307352, EBI-353818;
CC Q04864; O60573: EIF4E2; NbExp=3; IntAct=EBI-307352, EBI-398610;
CC Q04864; Q13541: EIF4EBP1; NbExp=3; IntAct=EBI-307352, EBI-74090;
CC Q04864; P63241: EIF5A; NbExp=3; IntAct=EBI-307352, EBI-373150;
CC Q04864; Q9GZV4: EIF5A2; NbExp=3; IntAct=EBI-307352, EBI-748028;
CC Q04864; O95834: EML2; NbExp=3; IntAct=EBI-307352, EBI-1054588;
CC Q04864; O15197-2: EPHB6; NbExp=3; IntAct=EBI-307352, EBI-10182490;
CC Q04864; Q7L775: EPM2AIP1; NbExp=3; IntAct=EBI-307352, EBI-6255981;
CC Q04864; Q9Y3B2: EXOSC1; NbExp=4; IntAct=EBI-307352, EBI-371892;
CC Q04864; Q9NQT4: EXOSC5; NbExp=3; IntAct=EBI-307352, EBI-371876;
CC Q04864; Q96B26: EXOSC8; NbExp=3; IntAct=EBI-307352, EBI-371922;
CC Q04864; Q14192: FHL2; NbExp=3; IntAct=EBI-307352, EBI-701903;
CC Q04864; P68106: FKBP1B; NbExp=3; IntAct=EBI-307352, EBI-6693977;
CC Q04864; Q8NFF5: FLAD1; NbExp=3; IntAct=EBI-307352, EBI-742815;
CC Q04864; P21333-2: FLNA; NbExp=3; IntAct=EBI-307352, EBI-9641086;
CC Q04864; Q9BVV2: FNDC11; NbExp=3; IntAct=EBI-307352, EBI-744935;
CC Q04864; P98177: FOXO4; NbExp=3; IntAct=EBI-307352, EBI-4481939;
CC Q04864; Q495W5: FUT11; NbExp=3; IntAct=EBI-307352, EBI-2907712;
CC Q04864; O95257: GADD45G; NbExp=4; IntAct=EBI-307352, EBI-448202;
CC Q04864; Q8IVS8: GLYCTK; NbExp=3; IntAct=EBI-307352, EBI-748515;
CC Q04864; P62993: GRB2; NbExp=3; IntAct=EBI-307352, EBI-401755;
CC Q04864; O14929: HAT1; NbExp=3; IntAct=EBI-307352, EBI-2339359;
CC Q04864; Q8WUI4-5: HDAC7; NbExp=3; IntAct=EBI-307352, EBI-10276431;
CC Q04864; O00291: HIP1; NbExp=3; IntAct=EBI-307352, EBI-473886;
CC Q04864; P06340: HLA-DOA; NbExp=3; IntAct=EBI-307352, EBI-10194851;
CC Q04864; Q9UBY9: HSPB7; NbExp=3; IntAct=EBI-307352, EBI-739361;
CC Q04864; Q9UBH0: IL36RN; NbExp=3; IntAct=EBI-307352, EBI-465156;
CC Q04864; Q08E86: KIAA0100; NbExp=3; IntAct=EBI-307352, EBI-10226057;
CC Q04864; Q5THT1: KLHL32; NbExp=3; IntAct=EBI-307352, EBI-10247181;
CC Q04864; Q9BYQ2: KRTAP9-4; NbExp=3; IntAct=EBI-307352, EBI-10185730;
CC Q04864; Q14847: LASP1; NbExp=3; IntAct=EBI-307352, EBI-742828;
CC Q04864; Q8TCE9: LGALS14; NbExp=4; IntAct=EBI-307352, EBI-10274069;
CC Q04864; P25800: LMO1; NbExp=3; IntAct=EBI-307352, EBI-8639312;
CC Q04864; P25791: LMO2; NbExp=3; IntAct=EBI-307352, EBI-739696;
CC Q04864; Q9UIQ6: LNPEP; NbExp=3; IntAct=EBI-307352, EBI-2805360;
CC Q04864; Q9Y333: LSM2; NbExp=3; IntAct=EBI-307352, EBI-347416;
CC Q04864; Q9UI95: MAD2L2; NbExp=3; IntAct=EBI-307352, EBI-77889;
CC Q04864; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-307352, EBI-746778;
CC Q04864; P57077-4: MAP3K7CL; NbExp=3; IntAct=EBI-307352, EBI-10215880;
CC Q04864; Q9Y316: MEMO1; NbExp=3; IntAct=EBI-307352, EBI-1104564;
CC Q04864; Q9BRT3: MIEN1; NbExp=3; IntAct=EBI-307352, EBI-6137472;
CC Q04864; Q9UBU8: MORF4L1; NbExp=3; IntAct=EBI-307352, EBI-399246;
CC Q04864; Q7Z7H8: MRPL10; NbExp=3; IntAct=EBI-307352, EBI-723524;
CC Q04864; Q9UJ70: NAGK; NbExp=3; IntAct=EBI-307352, EBI-372578;
CC Q04864; O43639: NCK2; NbExp=3; IntAct=EBI-307352, EBI-713635;
CC Q04864; Q9BU61-2: NDUFAF3; NbExp=3; IntAct=EBI-307352, EBI-10298649;
CC Q04864; A8K3C2: NECAP1; NbExp=3; IntAct=EBI-307352, EBI-10174302;
CC Q04864; Q14511: NEDD9; NbExp=3; IntAct=EBI-307352, EBI-2108053;
CC Q04864; Q969S2: NEIL2; NbExp=3; IntAct=EBI-307352, EBI-10281234;
CC Q04864; Q9Y4Z2: NEUROG3; NbExp=3; IntAct=EBI-307352, EBI-10328570;
CC Q04864; Q16236: NFE2L2; NbExp=5; IntAct=EBI-307352, EBI-2007911;
CC Q04864; Q00653: NFKB2; NbExp=2; IntAct=EBI-307352, EBI-307326;
CC Q04864; P25963: NFKBIA; NbExp=3; IntAct=EBI-307352, EBI-307386;
CC Q04864; O00221: NFKBIE; NbExp=2; IntAct=EBI-307352, EBI-355098;
CC Q04864; Q9NPG2: NGB; NbExp=3; IntAct=EBI-307352, EBI-10311409;
CC Q04864; Q9Y5B8: NME7; NbExp=3; IntAct=EBI-307352, EBI-744782;
CC Q04864; Q5SY16: NOL9; NbExp=3; IntAct=EBI-307352, EBI-1055462;
CC Q04864; Q86WQ0: NR2C2AP; NbExp=3; IntAct=EBI-307352, EBI-10260040;
CC Q04864; O95848: NUDT14; NbExp=3; IntAct=EBI-307352, EBI-536866;
CC Q04864; Q9NPJ8: NXT2; NbExp=3; IntAct=EBI-307352, EBI-752122;
CC Q04864; Q9UMX2: OAZ3; NbExp=3; IntAct=EBI-307352, EBI-10281601;
CC Q04864; Q9UJX0: OSGIN1; NbExp=3; IntAct=EBI-307352, EBI-9057006;
CC Q04864; Q92882: OSTF1; NbExp=3; IntAct=EBI-307352, EBI-1051152;
CC Q04864; Q96DC9: OTUB2; NbExp=3; IntAct=EBI-307352, EBI-746259;
CC Q04864; Q01804: OTUD4; NbExp=3; IntAct=EBI-307352, EBI-1054396;
CC Q04864; Q9HBI0: PARVG; NbExp=3; IntAct=EBI-307352, EBI-3921217;
CC Q04864; Q8WXA2: PATE1; NbExp=3; IntAct=EBI-307352, EBI-10277790;
CC Q04864; Q9HCN3: PGAP6; NbExp=3; IntAct=EBI-307352, EBI-10310808;
CC Q04864; Q8WWB5: PIH1D2; NbExp=4; IntAct=EBI-307352, EBI-10232538;
CC Q04864; Q15147: PLCB4; NbExp=3; IntAct=EBI-307352, EBI-998637;
CC Q04864; Q494U1: PLEKHN1; NbExp=4; IntAct=EBI-307352, EBI-10241513;
CC Q04864; P56282: POLE2; NbExp=3; IntAct=EBI-307352, EBI-713847;
CC Q04864; O95602: POLR1A; NbExp=3; IntAct=EBI-307352, EBI-359472;
CC Q04864; P62875: POLR2L; NbExp=3; IntAct=EBI-307352, EBI-359527;
CC Q04864; Q969H6: POP5; NbExp=3; IntAct=EBI-307352, EBI-366525;
CC Q04864; Q9NQV6: PRDM10; NbExp=3; IntAct=EBI-307352, EBI-10312448;
CC Q04864; P25786: PSMA1; NbExp=3; IntAct=EBI-307352, EBI-359352;
CC Q04864; P43115-12: PTGER3; NbExp=3; IntAct=EBI-307352, EBI-10234038;
CC Q04864; Q13882: PTK6; NbExp=3; IntAct=EBI-307352, EBI-1383632;
CC Q04864; Q9Y2K5-2: R3HDM2; NbExp=3; IntAct=EBI-307352, EBI-10326419;
CC Q04864; Q5JT25: RAB41; NbExp=3; IntAct=EBI-307352, EBI-10244509;
CC Q04864; P47224: RABIF; NbExp=3; IntAct=EBI-307352, EBI-713992;
CC Q04864; Q8WWW0: RASSF5; NbExp=3; IntAct=EBI-307352, EBI-367390;
CC Q04864; Q14498-3: RBM39; NbExp=3; IntAct=EBI-307352, EBI-6654703;
CC Q04864; Q6P9E2: RECK; NbExp=3; IntAct=EBI-307352, EBI-10253121;
CC Q04864; Q04206-2: RELA; NbExp=2; IntAct=EBI-307352, EBI-289947;
CC Q04864; Q04206-3: RELA; NbExp=3; IntAct=EBI-307352, EBI-10223388;
CC Q04864; Q8IX06: REXO1L1P; NbExp=3; IntAct=EBI-307352, EBI-10262361;
CC Q04864; Q0D2K3: RIPPLY1; NbExp=3; IntAct=EBI-307352, EBI-10226430;
CC Q04864; Q63HN8-6: RNF213; NbExp=3; IntAct=EBI-307352, EBI-10248548;
CC Q04864; Q9UHP6: RSPH14; NbExp=3; IntAct=EBI-307352, EBI-748350;
CC Q04864; P21673: SAT1; NbExp=3; IntAct=EBI-307352, EBI-711613;
CC Q04864; O00560: SDCBP; NbExp=3; IntAct=EBI-307352, EBI-727004;
CC Q04864; Q9UDX3: SEC14L4; NbExp=3; IntAct=EBI-307352, EBI-10320311;
CC Q04864; O94979: SEC31A; NbExp=3; IntAct=EBI-307352, EBI-1767898;
CC Q04864; Q16181-2: SEPTIN7; NbExp=3; IntAct=EBI-307352, EBI-10176094;
CC Q04864; Q96H72: SLC39A13; NbExp=3; IntAct=EBI-307352, EBI-10287091;
CC Q04864; Q96GZ6: SLC41A3; NbExp=3; IntAct=EBI-307352, EBI-7225508;
CC Q04864; P48065: SLC6A12; NbExp=3; IntAct=EBI-307352, EBI-3843589;
CC Q04864; Q9BV90: SNRNP25; NbExp=3; IntAct=EBI-307352, EBI-9675976;
CC Q04864; O75716: STK16; NbExp=3; IntAct=EBI-307352, EBI-749295;
CC Q04864; Q5T011-5: SZT2; NbExp=3; IntAct=EBI-307352, EBI-10245139;
CC Q04864; Q08117: TLE5; NbExp=3; IntAct=EBI-307352, EBI-717810;
CC Q04864; Q8NFZ5: TNIP2; NbExp=2; IntAct=EBI-307352, EBI-359372;
CC Q04864; Q63HR2: TNS2; NbExp=3; IntAct=EBI-307352, EBI-949753;
CC Q04864; Q9UL33: TRAPPC2L; NbExp=3; IntAct=EBI-307352, EBI-747601;
CC Q04864; Q86UV6-2: TRIM74; NbExp=3; IntAct=EBI-307352, EBI-10259086;
CC Q04864; Q9Y5U2: TSSC4; NbExp=3; IntAct=EBI-307352, EBI-717229;
CC Q04864; Q96PN8: TSSK3; NbExp=3; IntAct=EBI-307352, EBI-3918381;
CC Q04864; Q5T7W7: TSTD2; NbExp=3; IntAct=EBI-307352, EBI-8994397;
CC Q04864; Q6DKK2: TTC19; NbExp=3; IntAct=EBI-307352, EBI-948354;
CC Q04864; A0A0B4J1Y2: TTC21A; NbExp=3; IntAct=EBI-307352, EBI-10220701;
CC Q04864; Q9NX01: TXNL4B; NbExp=3; IntAct=EBI-307352, EBI-10309345;
CC Q04864; P57075: UBASH3A; NbExp=3; IntAct=EBI-307352, EBI-2105393;
CC Q04864; P61086: UBE2K; NbExp=3; IntAct=EBI-307352, EBI-473850;
CC Q04864; Q9H832: UBE2Z; NbExp=3; IntAct=EBI-307352, EBI-720977;
CC Q04864; Q9BRG1: VPS25; NbExp=4; IntAct=EBI-307352, EBI-741945;
CC Q04864; Q6UX98: ZDHHC24; NbExp=3; IntAct=EBI-307352, EBI-10254561;
CC Q04864; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-307352, EBI-740727;
CC Q04864; Q7Z398: ZNF550; NbExp=3; IntAct=EBI-307352, EBI-10256834;
CC Q04864; Q8TBZ8: ZNF564; NbExp=3; IntAct=EBI-307352, EBI-10273713;
CC Q04864; Q7Z3I7: ZNF572; NbExp=3; IntAct=EBI-307352, EBI-10172590;
CC Q04864; Q7L2R6: ZNF765; NbExp=3; IntAct=EBI-307352, EBI-9676069;
CC Q04864; A8K5H9; NbExp=3; IntAct=EBI-307352, EBI-10174421;
CC Q04864; B2R8Y4; NbExp=3; IntAct=EBI-307352, EBI-10175581;
CC Q04864; Q96BA4; NbExp=3; IntAct=EBI-307352, EBI-10282301;
CC Q04864; PRO_0000449627 [P0DTD1]: rep; Xeno; NbExp=3; IntAct=EBI-307352, EBI-25475877;
CC Q04864; PRO_0000449631 [P0DTD1]: rep; Xeno; NbExp=3; IntAct=EBI-307352, EBI-25475920;
CC Q04864; PRO_0000449633 [P0DTD1]: rep; Xeno; NbExp=3; IntAct=EBI-307352, EBI-25492395;
CC Q04864-2; K7EM05: ACBD4; NbExp=3; IntAct=EBI-10829018, EBI-16431307;
CC Q04864-2; Q8WYK0: ACOT12; NbExp=3; IntAct=EBI-10829018, EBI-11954993;
CC Q04864-2; O14734: ACOT8; NbExp=3; IntAct=EBI-10829018, EBI-1237371;
CC Q04864-2; P31751: AKT2; NbExp=3; IntAct=EBI-10829018, EBI-296058;
CC Q04864-2; P29972: AQP1; NbExp=3; IntAct=EBI-10829018, EBI-745213;
CC Q04864-2; P53365: ARFIP2; NbExp=3; IntAct=EBI-10829018, EBI-638194;
CC Q04864-2; Q0P5N6: ARL16; NbExp=3; IntAct=EBI-10829018, EBI-10186132;
CC Q04864-2; Q9H6L4: ARMC7; NbExp=3; IntAct=EBI-10829018, EBI-742909;
CC Q04864-2; Q8TDY4: ASAP3; NbExp=3; IntAct=EBI-10829018, EBI-2609717;
CC Q04864-2; O95671: ASMTL; NbExp=3; IntAct=EBI-10829018, EBI-743231;
CC Q04864-2; Q7Z3C6-3: ATG9A; NbExp=3; IntAct=EBI-10829018, EBI-12006308;
CC Q04864-2; Q8N8Y2: ATP6V0D2; NbExp=3; IntAct=EBI-10829018, EBI-3923949;
CC Q04864-2; Q8NEY4-2: ATP6V1C2; NbExp=3; IntAct=EBI-10829018, EBI-10270867;
CC Q04864-2; Q8N5M1: ATPAF2; NbExp=3; IntAct=EBI-10829018, EBI-1166928;
CC Q04864-2; P54253: ATXN1; NbExp=3; IntAct=EBI-10829018, EBI-930964;
CC Q04864-2; A0A0S2Z5G4: BANP; NbExp=3; IntAct=EBI-10829018, EBI-16429704;
CC Q04864-2; B4DE54: BANP; NbExp=3; IntAct=EBI-10829018, EBI-16429313;
CC Q04864-2; Q8N9N5-2: BANP; NbExp=6; IntAct=EBI-10829018, EBI-11524452;
CC Q04864-2; Q8N9N5-7: BANP; NbExp=3; IntAct=EBI-10829018, EBI-16429296;
CC Q04864-2; A0A0S2Z328: BBS4; NbExp=3; IntAct=EBI-10829018, EBI-16435728;
CC Q04864-2; Q96RK4: BBS4; NbExp=3; IntAct=EBI-10829018, EBI-1805814;
CC Q04864-2; Q5TBC7: BCL2L15; NbExp=3; IntAct=EBI-10829018, EBI-10247136;
CC Q04864-2; P41182: BCL6; NbExp=3; IntAct=EBI-10829018, EBI-765407;
CC Q04864-2; Q9H3H3-3: C11orf68; NbExp=3; IntAct=EBI-10829018, EBI-12002214;
CC Q04864-2; Q9NWQ9: C14orf119; NbExp=3; IntAct=EBI-10829018, EBI-725606;
CC Q04864-2; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-10829018, EBI-8643161;
CC Q04864-2; Q9BV19: C1orf50; NbExp=3; IntAct=EBI-10829018, EBI-2874661;
CC Q04864-2; Q96LT6: C1orf74; NbExp=3; IntAct=EBI-10829018, EBI-12049899;
CC Q04864-2; A0A0S2Z6I7: C6orf142; NbExp=3; IntAct=EBI-10829018, EBI-16435493;
CC Q04864-2; Q13698: CACNA1S; NbExp=3; IntAct=EBI-10829018, EBI-5329490;
CC Q04864-2; P24863: CCNC; NbExp=3; IntAct=EBI-10829018, EBI-395261;
CC Q04864-2; Q07002: CDK18; NbExp=3; IntAct=EBI-10829018, EBI-746238;
CC Q04864-2; P38936: CDKN1A; NbExp=3; IntAct=EBI-10829018, EBI-375077;
CC Q04864-2; P42773: CDKN2C; NbExp=3; IntAct=EBI-10829018, EBI-711290;
CC Q04864-2; P55273: CDKN2D; NbExp=3; IntAct=EBI-10829018, EBI-745859;
CC Q04864-2; Q86X02: CDR2L; NbExp=3; IntAct=EBI-10829018, EBI-11063830;
CC Q04864-2; Q96LK0: CEP19; NbExp=3; IntAct=EBI-10829018, EBI-741885;
CC Q04864-2; Q8IYR0: CFAP206; NbExp=3; IntAct=EBI-10829018, EBI-749051;
CC Q04864-2; Q9UFW8: CGGBP1; NbExp=3; IntAct=EBI-10829018, EBI-723153;
CC Q04864-2; Q13111: CHAF1A; NbExp=3; IntAct=EBI-10829018, EBI-1020839;
CC Q04864-2; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-10829018, EBI-741528;
CC Q04864-2; Q9BW66: CINP; NbExp=3; IntAct=EBI-10829018, EBI-739784;
CC Q04864-2; P30622: CLIP1; NbExp=3; IntAct=EBI-10829018, EBI-2683569;
CC Q04864-2; Q96FN4: CPNE2; NbExp=3; IntAct=EBI-10829018, EBI-7097057;
CC Q04864-2; Q9UBL6-2: CPNE7; NbExp=3; IntAct=EBI-10829018, EBI-12012272;
CC Q04864-2; P68400: CSNK2A1; NbExp=3; IntAct=EBI-10829018, EBI-347804;
CC Q04864-2; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-10829018, EBI-11962928;
CC Q04864-2; Q6BCY4-2: CYB5R2; NbExp=3; IntAct=EBI-10829018, EBI-12102608;
CC Q04864-2; P26196: DDX6; NbExp=3; IntAct=EBI-10829018, EBI-351257;
CC Q04864-2; Q9H4E7: DEF6; NbExp=3; IntAct=EBI-10829018, EBI-745369;
CC Q04864-2; P49366: DHPS; NbExp=3; IntAct=EBI-10829018, EBI-741925;
CC Q04864-2; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-10829018, EBI-9679045;
CC Q04864-2; Q5JVL4: EFHC1; NbExp=6; IntAct=EBI-10829018, EBI-743105;
CC Q04864-2; Q08426: EHHADH; NbExp=3; IntAct=EBI-10829018, EBI-2339219;
CC Q04864-2; P38919: EIF4A3; NbExp=3; IntAct=EBI-10829018, EBI-299104;
CC Q04864-2; Q13541: EIF4EBP1; NbExp=3; IntAct=EBI-10829018, EBI-74090;
CC Q04864-2; P63241: EIF5A; NbExp=3; IntAct=EBI-10829018, EBI-373150;
CC Q04864-2; Q9GZV4: EIF5A2; NbExp=3; IntAct=EBI-10829018, EBI-748028;
CC Q04864-2; P50402: EMD; NbExp=3; IntAct=EBI-10829018, EBI-489887;
CC Q04864-2; O15197-2: EPHB6; NbExp=3; IntAct=EBI-10829018, EBI-10182490;
CC Q04864-2; P11474: ESRRA; NbExp=3; IntAct=EBI-10829018, EBI-372412;
CC Q04864-2; P62508-3: ESRRG; NbExp=3; IntAct=EBI-10829018, EBI-12001340;
CC Q04864-2; Q9Y3B2: EXOSC1; NbExp=3; IntAct=EBI-10829018, EBI-371892;
CC Q04864-2; Q9NQT4: EXOSC5; NbExp=3; IntAct=EBI-10829018, EBI-371876;
CC Q04864-2; Q6NZ36-4: FAAP20; NbExp=3; IntAct=EBI-10829018, EBI-12013806;
CC Q04864-2; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-10829018, EBI-6658203;
CC Q04864-2; P68106-2: FKBP1B; NbExp=3; IntAct=EBI-10829018, EBI-11998976;
CC Q04864-2; Q8NFF5-2: FLAD1; NbExp=3; IntAct=EBI-10829018, EBI-11526128;
CC Q04864-2; Q53EP0-3: FNDC3B; NbExp=3; IntAct=EBI-10829018, EBI-10242151;
CC Q04864-2; Q8IVS8: GLYCTK; NbExp=3; IntAct=EBI-10829018, EBI-748515;
CC Q04864-2; Q92917: GPKOW; NbExp=3; IntAct=EBI-10829018, EBI-746309;
CC Q04864-2; Q13588: GRAP; NbExp=3; IntAct=EBI-10829018, EBI-2847510;
CC Q04864-2; O14929: HAT1; NbExp=3; IntAct=EBI-10829018, EBI-2339359;
CC Q04864-2; A0A024R8L2: hCG_1987119; NbExp=3; IntAct=EBI-10829018, EBI-14103818;
CC Q04864-2; Q8WUI4-6: HDAC7; NbExp=3; IntAct=EBI-10829018, EBI-12094670;
CC Q04864-2; P52597: HNRNPF; NbExp=3; IntAct=EBI-10829018, EBI-352986;
CC Q04864-2; Q9BPX1: HSD17B14; NbExp=3; IntAct=EBI-10829018, EBI-742664;
CC Q04864-2; Q9UBY9: HSPB7; NbExp=3; IntAct=EBI-10829018, EBI-739361;
CC Q04864-2; Q9UBH0: IL36RN; NbExp=3; IntAct=EBI-10829018, EBI-465156;
CC Q04864-2; Q8NC69: KCTD6; NbExp=3; IntAct=EBI-10829018, EBI-2511344;
CC Q04864-2; Q96MP8-2: KCTD7; NbExp=3; IntAct=EBI-10829018, EBI-11954971;
CC Q04864-2; Q9P2K6: KLHL42; NbExp=3; IntAct=EBI-10829018, EBI-739890;
CC Q04864-2; Q969R5: L3MBTL2; NbExp=3; IntAct=EBI-10829018, EBI-739909;
CC Q04864-2; Q96BZ8: LENG1; NbExp=4; IntAct=EBI-10829018, EBI-726510;
CC Q04864-2; Q9UI95: MAD2L2; NbExp=3; IntAct=EBI-10829018, EBI-77889;
CC Q04864-2; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-10829018, EBI-746778;
CC Q04864-2; Q9UPY8: MAPRE3; NbExp=3; IntAct=EBI-10829018, EBI-726739;
CC Q04864-2; Q8IYB1: MB21D2; NbExp=3; IntAct=EBI-10829018, EBI-11323212;
CC Q04864-2; O95983-2: MBD3; NbExp=3; IntAct=EBI-10829018, EBI-11978579;
CC Q04864-2; Q9BUN1: MENT; NbExp=3; IntAct=EBI-10829018, EBI-12022316;
CC Q04864-2; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-10829018, EBI-10172526;
CC Q04864-2; Q9BRT3: MIEN1; NbExp=3; IntAct=EBI-10829018, EBI-6137472;
CC Q04864-2; Q8TD10: MIPOL1; NbExp=3; IntAct=EBI-10829018, EBI-2548751;
CC Q04864-2; P08253: MMP2; NbExp=3; IntAct=EBI-10829018, EBI-1033518;
CC Q04864-2; Q15014: MORF4L2; NbExp=3; IntAct=EBI-10829018, EBI-399257;
CC Q04864-2; Q8IXL7-2: MSRB3; NbExp=3; IntAct=EBI-10829018, EBI-10699187;
CC Q04864-2; Q8N3F0: MTURN; NbExp=3; IntAct=EBI-10829018, EBI-11980301;
CC Q04864-2; Q96AH0: NABP1; NbExp=3; IntAct=EBI-10829018, EBI-2889252;
CC Q04864-2; O43639: NCK2; NbExp=3; IntAct=EBI-10829018, EBI-713635;
CC Q04864-2; Q969S2: NEIL2; NbExp=3; IntAct=EBI-10829018, EBI-10281234;
CC Q04864-2; Q9NPG2: NGB; NbExp=3; IntAct=EBI-10829018, EBI-10311409;
CC Q04864-2; Q9NWW6: NMRK1; NbExp=3; IntAct=EBI-10829018, EBI-10315485;
CC Q04864-2; Q86UR1-2: NOXA1; NbExp=3; IntAct=EBI-10829018, EBI-12025760;
CC Q04864-2; Q86WQ0: NR2C2AP; NbExp=3; IntAct=EBI-10829018, EBI-10260040;
CC Q04864-2; Q8NFP7: NUDT10; NbExp=3; IntAct=EBI-10829018, EBI-726826;
CC Q04864-2; Q9UMX2-2: OAZ3; NbExp=3; IntAct=EBI-10829018, EBI-12049527;
CC Q04864-2; Q9UJX0: OSGIN1; NbExp=3; IntAct=EBI-10829018, EBI-9057006;
CC Q04864-2; Q96DC9: OTUB2; NbExp=3; IntAct=EBI-10829018, EBI-746259;
CC Q04864-2; Q9ULW8: PADI3; NbExp=3; IntAct=EBI-10829018, EBI-10488185;
CC Q04864-2; A0A0S2Z5D3: PAK1IP1; NbExp=3; IntAct=EBI-10829018, EBI-16431731;
CC Q04864-2; Q9HBI0: PARVG; NbExp=3; IntAct=EBI-10829018, EBI-3921217;
CC Q04864-2; Q99447: PCYT2; NbExp=3; IntAct=EBI-10829018, EBI-750317;
CC Q04864-2; Q9HAT8: PELI2; NbExp=3; IntAct=EBI-10829018, EBI-448407;
CC Q04864-2; Q9HCN3: PGAP6; NbExp=3; IntAct=EBI-10829018, EBI-10310808;
CC Q04864-2; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-10829018, EBI-79165;
CC Q04864-2; Q494U1-3: PLEKHN1; NbExp=3; IntAct=EBI-10829018, EBI-12014286;
CC Q04864-2; Q8IYS1: PM20D2; NbExp=3; IntAct=EBI-10829018, EBI-11339910;
CC Q04864-2; P62875: POLR2L; NbExp=3; IntAct=EBI-10829018, EBI-359527;
CC Q04864-2; P54646: PRKAA2; NbExp=4; IntAct=EBI-10829018, EBI-1383852;
CC Q04864-2; O43741: PRKAB2; NbExp=4; IntAct=EBI-10829018, EBI-1053424;
CC Q04864-2; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-10829018, EBI-1567797;
CC Q04864-2; P25789: PSMA4; NbExp=3; IntAct=EBI-10829018, EBI-359310;
CC Q04864-2; P28062-2: PSMB8; NbExp=3; IntAct=EBI-10829018, EBI-372312;
CC Q04864-2; Q9UIG4: PSORS1C2; NbExp=3; IntAct=EBI-10829018, EBI-11974061;
CC Q04864-2; P47897: QARS1; NbExp=3; IntAct=EBI-10829018, EBI-347462;
CC Q04864-2; O14966: RAB29; NbExp=3; IntAct=EBI-10829018, EBI-372165;
CC Q04864-2; P54725: RAD23A; NbExp=3; IntAct=EBI-10829018, EBI-746453;
CC Q04864-2; O75771: RAD51D; NbExp=3; IntAct=EBI-10829018, EBI-1055693;
CC Q04864-2; A0A0S2Z4G9: RNF6; NbExp=3; IntAct=EBI-10829018, EBI-16428950;
CC Q04864-2; A6ZKI3: RTL8C; NbExp=3; IntAct=EBI-10829018, EBI-10174072;
CC Q04864-2; Q06455-2: RUNX1T1; NbExp=3; IntAct=EBI-10829018, EBI-11984663;
CC Q04864-2; Q5T7Y4: S100A1; NbExp=3; IntAct=EBI-10829018, EBI-16435788;
CC Q04864-2; Q96NU1: SAMD11; NbExp=3; IntAct=EBI-10829018, EBI-14067109;
CC Q04864-2; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-10829018, EBI-748391;
CC Q04864-2; Q9UDX3: SEC14L4; NbExp=3; IntAct=EBI-10829018, EBI-10320311;
CC Q04864-2; Q92529: SHC3; NbExp=3; IntAct=EBI-10829018, EBI-79084;
CC Q04864-2; Q15475: SIX1; NbExp=3; IntAct=EBI-10829018, EBI-743675;
CC Q04864-2; Q9H0W8: SMG9; NbExp=3; IntAct=EBI-10829018, EBI-2872322;
CC Q04864-2; Q9BV90: SNRNP25; NbExp=3; IntAct=EBI-10829018, EBI-9675976;
CC Q04864-2; Q9H0A9-2: SPATC1L; NbExp=3; IntAct=EBI-10829018, EBI-11995806;
CC Q04864-2; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-10829018, EBI-742688;
CC Q04864-2; O43609: SPRY1; NbExp=3; IntAct=EBI-10829018, EBI-3866665;
CC Q04864-2; Q96FJ0: STAMBPL1; NbExp=3; IntAct=EBI-10829018, EBI-745021;
CC Q04864-2; O75716: STK16; NbExp=3; IntAct=EBI-10829018, EBI-749295;
CC Q04864-2; O00204: SULT2B1; NbExp=3; IntAct=EBI-10829018, EBI-749441;
CC Q04864-2; P51687: SUOX; NbExp=3; IntAct=EBI-10829018, EBI-3921347;
CC Q04864-2; Q8IYX1: TBC1D21; NbExp=3; IntAct=EBI-10829018, EBI-12018146;
CC Q04864-2; Q9NU19: TBC1D22B; NbExp=3; IntAct=EBI-10829018, EBI-8787464;
CC Q04864-2; P56279: TCL1A; NbExp=3; IntAct=EBI-10829018, EBI-749995;
CC Q04864-2; Q9NUJ3: TCP11L1; NbExp=3; IntAct=EBI-10829018, EBI-2555179;
CC Q04864-2; Q96FV9: THOC1; NbExp=3; IntAct=EBI-10829018, EBI-1765605;
CC Q04864-2; O43711: TLX3; NbExp=3; IntAct=EBI-10829018, EBI-3939165;
CC Q04864-2; Q9UL33-2: TRAPPC2L; NbExp=3; IntAct=EBI-10829018, EBI-11119202;
CC Q04864-2; O75865-2: TRAPPC6A; NbExp=3; IntAct=EBI-10829018, EBI-8451480;
CC Q04864-2; Q6AZZ1: TRIM68; NbExp=3; IntAct=EBI-10829018, EBI-2130449;
CC Q04864-2; Q99576: TSC22D3; NbExp=3; IntAct=EBI-10829018, EBI-750174;
CC Q04864-2; Q8WW01: TSEN15; NbExp=3; IntAct=EBI-10829018, EBI-372432;
CC Q04864-2; Q96PN8: TSSK3; NbExp=3; IntAct=EBI-10829018, EBI-3918381;
CC Q04864-2; Q5T7W7: TSTD2; NbExp=3; IntAct=EBI-10829018, EBI-8994397;
CC Q04864-2; Q8TF42: UBASH3B; NbExp=3; IntAct=EBI-10829018, EBI-1380492;
CC Q04864-2; Q9Y2X8: UBE2D4; NbExp=3; IntAct=EBI-10829018, EBI-745527;
CC Q04864-2; O94888: UBXN7; NbExp=3; IntAct=EBI-10829018, EBI-1993627;
CC Q04864-2; Q9BYP7: WNK3; NbExp=3; IntAct=EBI-10829018, EBI-1182602;
CC Q04864-2; A0A0S2Z4P3: YARS; NbExp=3; IntAct=EBI-10829018, EBI-16435800;
CC Q04864-2; Q9BW85: YJU2; NbExp=3; IntAct=EBI-10829018, EBI-10300345;
CC Q04864-2; Q8IZ13: ZBED8; NbExp=3; IntAct=EBI-10829018, EBI-7186123;
CC Q04864-2; Q05516: ZBTB16; NbExp=3; IntAct=EBI-10829018, EBI-711925;
CC Q04864-2; Q6UX98: ZDHHC24; NbExp=3; IntAct=EBI-10829018, EBI-10254561;
CC Q04864-2; Q15915: ZIC1; NbExp=3; IntAct=EBI-10829018, EBI-11963196;
CC Q04864-2; Q9NWS9-2: ZNF446; NbExp=3; IntAct=EBI-10829018, EBI-740232;
CC Q04864-2; A0A0S2Z5X4: ZNF688; NbExp=3; IntAct=EBI-10829018, EBI-16429014;
CC Q04864-2; A0A0S2Z6P0: ZNF688; NbExp=3; IntAct=EBI-10829018, EBI-16429989;
CC Q04864-2; P36508: ZNF76; NbExp=3; IntAct=EBI-10829018, EBI-7254550;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q04864-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q04864-2; Sequence=VSP_055857;
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/RELID322.html";
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DR EMBL; X75042; CAA52954.1; -; mRNA.
DR EMBL; DQ314888; ABC40747.1; -; Genomic_DNA.
DR EMBL; AC010733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC117191; AAI17192.1; -; mRNA.
DR EMBL; BC143885; AAI43886.1; -; mRNA.
DR EMBL; M11595; AAA52073.1; -; Genomic_DNA.
DR CCDS; CCDS1864.1; -. [Q04864-1]
DR CCDS; CCDS74515.1; -. [Q04864-2]
DR PIR; A60646; A60646.
DR RefSeq; NP_001278675.1; NM_001291746.1. [Q04864-2]
DR RefSeq; NP_002899.1; NM_002908.3. [Q04864-1]
DR AlphaFoldDB; Q04864; -.
DR SMR; Q04864; -.
DR BioGRID; 111898; 358.
DR ComplexPortal; CPX-5830; NF-kappaB DNA-binding transcription factor complex, p52/c-Rel.
DR ComplexPortal; CPX-5832; NF-kappaB DNA-binding transcription factor complex, p50/c-Rel.
DR ComplexPortal; CPX-5834; NF-kappaB DNA-binding transcription factor complex, p65/c-Rel.
DR ComplexPortal; CPX-5836; NF-kappaB DNA-binding transcription factor complex, c-Rel/c-Rel.
DR CORUM; Q04864; -.
DR DIP; DIP-301N; -.
DR IntAct; Q04864; 337.
DR MINT; Q04864; -.
DR STRING; 9606.ENSP00000295025; -.
DR ChEMBL; CHEMBL4296310; -.
DR GlyGen; Q04864; 6 sites, 2 O-linked glycans (6 sites).
DR iPTMnet; Q04864; -.
DR PhosphoSitePlus; Q04864; -.
DR BioMuta; REL; -.
DR DMDM; 548720; -.
DR EPD; Q04864; -.
DR jPOST; Q04864; -.
DR MassIVE; Q04864; -.
DR MaxQB; Q04864; -.
DR PaxDb; Q04864; -.
DR PeptideAtlas; Q04864; -.
DR PRIDE; Q04864; -.
DR ProteomicsDB; 58288; -. [Q04864-1]
DR ProteomicsDB; 61167; -.
DR Antibodypedia; 3830; 842 antibodies from 49 providers.
DR DNASU; 5966; -.
DR Ensembl; ENST00000295025.12; ENSP00000295025.7; ENSG00000162924.15. [Q04864-1]
DR Ensembl; ENST00000394479.4; ENSP00000377989.4; ENSG00000162924.15. [Q04864-2]
DR GeneID; 5966; -.
DR KEGG; hsa:5966; -.
DR MANE-Select; ENST00000394479.4; ENSP00000377989.4; NM_001291746.2; NP_001278675.1. [Q04864-2]
DR UCSC; uc002sam.2; human. [Q04864-1]
DR CTD; 5966; -.
DR DisGeNET; 5966; -.
DR GeneCards; REL; -.
DR HGNC; HGNC:9954; REL.
DR HPA; ENSG00000162924; Tissue enhanced (bone).
DR MIM; 164910; gene.
DR neXtProt; NX_Q04864; -.
DR OpenTargets; ENSG00000162924; -.
DR PharmGKB; PA34321; -.
DR VEuPathDB; HostDB:ENSG00000162924; -.
DR eggNOG; ENOG502QQS6; Eukaryota.
DR GeneTree; ENSGT00940000158732; -.
DR HOGENOM; CLU_004343_5_0_1; -.
DR InParanoid; Q04864; -.
DR OMA; NCPVNMI; -.
DR OrthoDB; 916931at2759; -.
DR PhylomeDB; Q04864; -.
DR TreeFam; TF325632; -.
DR PathwayCommons; Q04864; -.
DR Reactome; R-HSA-1169091; Activation of NF-kappaB in B cells.
DR SignaLink; Q04864; -.
DR SIGNOR; Q04864; -.
DR BioGRID-ORCS; 5966; 11 hits in 1094 CRISPR screens.
DR ChiTaRS; REL; human.
DR GeneWiki; REL; -.
DR GenomeRNAi; 5966; -.
DR Pharos; Q04864; Tbio.
DR PRO; PR:Q04864; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q04864; protein.
DR Bgee; ENSG00000162924; Expressed in buccal mucosa cell and 172 other tissues.
DR ExpressionAtlas; Q04864; baseline and differential.
DR Genevisible; Q04864; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0071159; C:NF-kappaB complex; IC:ComplexPortal.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; IMP:CACAO.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:ProtInc.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0010629; P:negative regulation of gene expression; IDA:CACAO.
DR GO; GO:0032688; P:negative regulation of interferon-beta production; IDA:CACAO.
DR GO; GO:0038061; P:NIK/NF-kappaB signaling; IBA:GO_Central.
DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEP:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0034097; P:response to cytokine; IBA:GO_Central.
DR CDD; cd01177; IPT_NFkappaB; 1.
DR CDD; cd07933; RHD-n_c-Rel; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 2.60.40.340; -; 1.
DR InterPro; IPR030505; c-Rel.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR033926; IPT_NFkappaB.
DR InterPro; IPR000451; NFkB/Dor.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR InterPro; IPR042845; RHD-n_c-Rel.
DR InterPro; IPR030492; RHD_CS.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR24169; PTHR24169; 1.
DR PANTHER; PTHR24169:SF4; PTHR24169:SF4; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR00057; NFKBTNSCPFCT.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
DR PROSITE; PS01204; REL_1; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 1: Evidence at protein level;
KW Acetylation; Activator; Alternative splicing; DNA-binding; Nucleus;
KW Phosphoprotein; Proto-oncogene; Reference proteome; Transcription;
KW Transcription regulation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:22814378"
FT CHAIN 2..619
FT /note="Proto-oncogene c-Rel"
FT /id="PRO_0000205165"
FT DOMAIN 8..297
FT /note="RHD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00265"
FT REGION 399..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 572..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 290..295
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:22814378"
FT MOD_RES 267
FT /note="Phosphoserine; by PKA"
FT /evidence="ECO:0000255"
FT MOD_RES 503
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:10823840"
FT VAR_SEQ 308..339
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_055857"
SQ SEQUENCE 619 AA; 68520 MW; 03E1033BDF7B1B30 CRC64;
MASGAYNPYI EIIEQPRQRG MRFRYKCEGR SAGSIPGEHS TDNNRTYPSI QIMNYYGKGK
VRITLVTKND PYKPHPHDLV GKDCRDGYYE AEFGQERRPL FFQNLGIRCV KKKEVKEAII
TRIKAGINPF NVPEKQLNDI EDCDLNVVRL CFQVFLPDEH GNLTTALPPV VSNPIYDNRA
PNTAELRICR VNKNCGSVRG GDEIFLLCDK VQKDDIEVRF VLNDWEAKGI FSQADVHRQV
AIVFKTPPYC KAITEPVTVK MQLRRPSDQE VSESMDFRYL PDEKDTYGNK AKKQKTTLLF
QKLCQDHVET GFRHVDQDGL ELLTSGDPPT LASQSAGITV NFPERPRPGL LGSIGEGRYF
KKEPNLFSHD AVVREMPTGV SSQAESYYPS PGPISSGLSH HASMAPLPSS SWSSVAHPTP
RSGNTNPLSS FSTRTLPSNS QGIPPFLRIP VGNDLNASNA CIYNNADDIV GMEASSMPSA
DLYGISDPNM LSNCSVNMMT TSSDSMGETD NPRLLSMNLE NPSCNSVLDP RDLRQLHQMS
SSSMSAGANS NTTVFVSQSD AFEGSDFSCA DNSMINESGP SNSTNPNSHG FVQDSQYSGI
GSMQNEQLSD SFPYEFFQV
