REM19_ARATH
ID REM19_ARATH Reviewed; 226 AA.
AC Q9XIB5; Q94B43;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=B3 domain-containing protein REM19;
DE AltName: Full=Protein RELATED TO VERNALIZATION 1;
DE AltName: Full=Protein REPRODUCTIVE MERISTEM 19;
GN Name=REM19; Synonyms=RTV1; OrderedLocusNames=At1g49480; ORFNames=F13F21.8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=18986826; DOI=10.1016/j.tplants.2008.09.006;
RA Swaminathan K., Peterson K., Jack T.;
RT "The plant B3 superfamily.";
RL Trends Plant Sci. 13:647-655(2008).
RN [6]
RP INTERACTION WITH ITN1.
RX PubMed=22664102; DOI=10.1016/j.bbrc.2012.05.136;
RA Sakamoto H., Sakata K., Kusumi K., Kojima M., Sakakibara H., Iba K.;
RT "Interaction between a plasma membrane-localized ankyrin-repeat protein
RT ITN1 and a nuclear protein RTV1.";
RL Biochem. Biophys. Res. Commun. 423:392-397(2012).
RN [7]
RP INTERACTION WITH XLG2, INDUCTION BY COLD, DNA-BINDING, FUNCTION,
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=22232549; DOI=10.1074/jbc.m111.317412;
RA Heo J.B., Sung S., Assmann S.M.;
RT "Ca2+-dependent GTPase, extra-large G protein 2 (XLG2), promotes activation
RT of DNA-binding protein related to vernalization 1 (RTV1), leading to
RT activation of floral integrator genes and early flowering in Arabidopsis.";
RL J. Biol. Chem. 287:8242-8253(2012).
CC -!- FUNCTION: Involved in the regulation of vernalization (By similarity).
CC Binds to DNA in vitro in a non-sequence-specific manner. XLG2 promotes
CC the DNA binding activity of RTV1 specifically to promoter regions of FT
CC and SOC1 in vivo and thus leads to the activation of floral integrator
CC genes. {ECO:0000250, ECO:0000269|PubMed:22232549}.
CC -!- SUBUNIT: Interacts with XLG2 (PubMed:22232549). Interacts with ITN1
CC (PubMed:22664102). {ECO:0000269|PubMed:22232549,
CC ECO:0000269|PubMed:22664102}.
CC -!- INTERACTION:
CC Q9XIB5; C6KIE6: XLG2; NbExp=4; IntAct=EBI-6869217, EBI-6868693;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00326,
CC ECO:0000269|PubMed:22232549}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:22232549}.
CC -!- INDUCTION: By cold. {ECO:0000269|PubMed:22232549}.
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DR EMBL; AC007504; AAD43153.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE32434.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM59711.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM59712.1; -; Genomic_DNA.
DR EMBL; AY042868; AAK68808.1; -; mRNA.
DR EMBL; BT015682; AAU15181.1; -; mRNA.
DR PIR; E96531; E96531.
DR RefSeq; NP_001322051.1; NM_001333385.1.
DR RefSeq; NP_001322052.1; NM_001333384.1.
DR RefSeq; NP_564547.1; NM_103836.4.
DR AlphaFoldDB; Q9XIB5; -.
DR SMR; Q9XIB5; -.
DR BioGRID; 26597; 2.
DR IntAct; Q9XIB5; 1.
DR STRING; 3702.AT1G49480.1; -.
DR iPTMnet; Q9XIB5; -.
DR PaxDb; Q9XIB5; -.
DR PRIDE; Q9XIB5; -.
DR ProteomicsDB; 225955; -.
DR EnsemblPlants; AT1G49480.1; AT1G49480.1; AT1G49480.
DR EnsemblPlants; AT1G49480.2; AT1G49480.2; AT1G49480.
DR EnsemblPlants; AT1G49480.3; AT1G49480.3; AT1G49480.
DR GeneID; 841372; -.
DR Gramene; AT1G49480.1; AT1G49480.1; AT1G49480.
DR Gramene; AT1G49480.2; AT1G49480.2; AT1G49480.
DR Gramene; AT1G49480.3; AT1G49480.3; AT1G49480.
DR KEGG; ath:AT1G49480; -.
DR Araport; AT1G49480; -.
DR TAIR; locus:2010262; AT1G49480.
DR eggNOG; ENOG502RXD2; Eukaryota.
DR HOGENOM; CLU_015069_6_0_1; -.
DR InParanoid; Q9XIB5; -.
DR OMA; EPVNKGY; -.
DR OrthoDB; 1255266at2759; -.
DR PhylomeDB; Q9XIB5; -.
DR PRO; PR:Q9XIB5; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9XIB5; baseline and differential.
DR Genevisible; Q9XIB5; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
DR GO; GO:0009409; P:response to cold; IEP:UniProtKB.
DR CDD; cd10017; B3_DNA; 1.
DR Gene3D; 2.40.330.10; -; 1.
DR InterPro; IPR003340; B3_DNA-bd.
DR InterPro; IPR015300; DNA-bd_pseudobarrel_sf.
DR Pfam; PF02362; B3; 1.
DR SMART; SM01019; B3; 1.
DR SUPFAM; SSF101936; SSF101936; 1.
DR PROSITE; PS50863; B3; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..226
FT /note="B3 domain-containing protein REM19"
FT /id="PRO_0000375112"
FT DNA_BIND 129..223
FT /note="TF-B3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00326"
FT REGION 1..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 70..73
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 33..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 32
FT /note="N -> I (in Ref. 3; AAK68808)"
FT /evidence="ECO:0000305"
FT CONFLICT 48
FT /note="A -> D (in Ref. 3; AAK68808)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 226 AA; 25850 MW; CB902C811E446A67 CRC64;
MQMDSAQNQF NKRARLFEDP ELKDAKVIYP SNPESTEPVN KGYGGSTAIQ SFFKESKAEE
TPKVLKKRGR KKKNPNPEEV NSSTPGGDDS ENRSKFYESA SARKRTVTAE ERERAVNAAK
TFEPTNPYFR VVLRPSYLYR GCIMYLPSGF AEKYLSGISG FIKLQLGEKQ WPVRCLYKAG
RAKFSQGWYE FTLENNIGEG DVCVFELLRT RDFVLEVTAF RVNEYV
