ID   RENBP_CANLF             Reviewed;          35 AA.
AC   O18921;
DT   09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=N-acylglucosamine 2-epimerase;
DE            Short=AGE;
DE            EC=5.1.3.8;
DE   AltName: Full=GlcNAc 2-epimerase;
DE   AltName: Full=N-acetyl-D-glucosamine 2-epimerase;
DE   AltName: Full=Renin-binding protein;
DE            Short=RnBP;
DE   Flags: Fragment;
GN   Name=RENBP {ECO:0000250|UniProtKB:P51606};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9745680;
RA   Stoy S.J., Shibuya H., O'Brien D., Johnson G.S.;
RT   "A BsII PCR/RFLP in the renin binding protein (RnBP) gene on canine
RT   chromosome X.";
RL   Anim. Genet. 29:327-328(1998).
CC   -!- FUNCTION: Catalyzes the interconversion of N-acetylglucosamine to N-
CC       acetylmannosamine. Binds to renin forming a protein complex called high
CC       molecular weight (HMW) renin and inhibits renin activity. Involved in
CC       the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an N-acyl-D-glucosamine = an N-acyl-D-mannosamine;
CC         Xref=Rhea:RHEA:19033, ChEBI:CHEBI:16062, ChEBI:CHEBI:17274;
CC         EC=5.1.3.8; Evidence={ECO:0000250|UniProtKB:P17560};
CC   -!- PATHWAY: Amino-sugar metabolism; N-acetylneuraminate degradation.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P17560}.
CC   -!- SIMILARITY: Belongs to the N-acylglucosamine 2-epimerase family.
CC       {ECO:0000255}.
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DR   EMBL; AF033014; AAB86966.1; -; Genomic_DNA.
DR   AlphaFoldDB; O18921; -.
DR   SMR; O18921; -.
DR   STRING; 9612.ENSCAFP00000028704; -.
DR   PaxDb; O18921; -.
DR   eggNOG; ENOG502QSDA; Eukaryota.
DR   UniPathway; UPA00629; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0050121; F:N-acylglucosamine 2-epimerase activity; ISS:UniProtKB.
DR   GO; GO:0019262; P:N-acetylneuraminate catabolic process; IEA:UniProtKB-UniPathway.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           <1..>35
FT                   /note="N-acylglucosamine 2-epimerase"
FT                   /id="PRO_0000208948"
FT   REGION          <1..21
FT                   /note="Leucine-zipper"
FT   NON_TER         1
FT                   /evidence="ECO:0000303|PubMed:9745680"
FT   NON_TER         35
FT                   /evidence="ECO:0000303|PubMed:9745680"
SQ   SEQUENCE   35 AA;  3955 MW;  DC1C059A181B5661 CRC64;
     LNLVDQLGEA DEELAGTYAE LGDWCAQRIL QHVQR