ID   REN_ABMVW               Reviewed;         132 AA.
AC   P21943;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   23-FEB-2022, entry version 75.
DE   RecName: Full=Replication enhancer protein;
DE            Short=REn;
DE   AltName: Full=Protein AC3;
DE   AltName: Full=Protein AL3;
GN   ORFNames=AC3, AL3;
OS   Abutilon mosaic virus (isolate West India) (AbMV).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Repensiviricetes;
OC   Geplafuvirales; Geminiviridae; Begomovirus.
OX   NCBI_TaxID=10816;
OH   NCBI_TaxID=3630; Abutilon.
OH   NCBI_TaxID=3635; Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OH   NCBI_TaxID=47605; Hibiscus.
OH   NCBI_TaxID=96479; Malva.
OH   NCBI_TaxID=3885; Phaseolus vulgaris (Kidney bean) (French bean).
OH   NCBI_TaxID=108335; Sida.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2219703; DOI=10.1016/0042-6822(90)90343-p;
RA   Frischmuth T., Zimmat G., Jeske H.;
RT   "The nucleotide sequence of abutilon mosaic virus reveals prokaryotic as
RT   well as eukaryotic features.";
RL   Virology 178:461-468(1990).
CC   -!- FUNCTION: Increases viral DNA accumulation. Enhances infectivity and
CC       symptom expression (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. Interacts with the replication-associated
CC       protein (REP). Interacts with host proliferating cell nuclear antigen
CC       (PCNA). Interacts with host retinoblastoma-related protein 1 (RBR1),
CC       and may thereby deregulate the host cell cycle. Oligomerization and
CC       interaction with PCNA are necessary for optimal replication enhancement
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the geminiviridae replication enhancer protein
CC       family. {ECO:0000305}.
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DR   EMBL; X15983; CAA34113.1; -; Genomic_DNA.
DR   PIR; C36214; QQCVW3.
DR   RefSeq; NP_047216.1; NC_001928.2.
DR   GeneID; 956373; -.
DR   KEGG; vg:956373; -.
DR   Proteomes; UP000006885; Genome.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR000657; Gemini_AL3.
DR   Pfam; PF01407; Gemini_AL3; 1.
DR   PRINTS; PR00231; GEMCOATAL3.
PE   3: Inferred from homology;
KW   Host-virus interaction.
FT   CHAIN           1..132
FT                   /note="Replication enhancer protein"
FT                   /id="PRO_0000222236"
SQ   SEQUENCE   132 AA;  15899 MW;  4AF1BD9FA90CB9BC CRC64;
     MDSRTGEFIT VHQAENGVYI WEIANPLYFR IYKVEDPLYT RTRIYHVQIR FNHNLRRALH
     LHKAYLNFQV WTTSMTASGS IYLNRFRRLV NMYLDQLGVI SINNVIRAVQ FATNRTYVNY
     VLENHSIKFK FY