ID   REN_BCTVC               Reviewed;         136 AA.
AC   P14994; Q91J27;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   12-AUG-2020, entry version 59.
DE   RecName: Full=Replication enhancer;
DE            Short=REn;
DE   AltName: Full=16.1 kDa protein;
DE   AltName: Full=Protein C3;
DE   AltName: Full=Protein L3;
GN   ORFNames=C3, L3;
OS   Beet curly top virus (strain California/Logan) (BCTV).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Repensiviricetes;
OC   Geplafuvirales; Geminiviridae; Curtovirus.
OX   NCBI_TaxID=268960;
OH   NCBI_TaxID=161934; Beta vulgaris (Sugar beet).
OH   NCBI_TaxID=4071; Capsicum (peppers).
OH   NCBI_TaxID=3650; Cucurbitaceae.
OH   NCBI_TaxID=4005; Linum.
OH   NCBI_TaxID=3885; Phaseolus vulgaris (Kidney bean) (French bean).
OH   NCBI_TaxID=4081; Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OH   NCBI_TaxID=4113; Solanum tuberosum (Potato).
OH   NCBI_TaxID=3562; Spinacia oleracea (Spinach).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Infectious clone pBCT028;
RX   PubMed=16453696; DOI=10.1002/j.1460-2075.1986.tb04424.x;
RA   Stanley J., Markham P.G., Callis R.J., Pinner M.S.;
RT   "The nucleotide sequence of an infectious clone of the geminivirus beet
RT   curly top virus.";
RL   EMBO J. 5:1761-1767(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Bisaro D.M., Hormuzdi S.G.;
RL   Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION.
RX   PubMed=7856079; DOI=10.1006/viro.1995.1027;
RA   Hormuzdi S.G., Bisaro D.M.;
RT   "Genetic analysis of beet curly top virus: examination of the roles of L2
RT   and L3 genes in viral pathogenesis.";
RL   Virology 206:1044-1054(1995).
CC   -!- FUNCTION: Increases viral DNA accumulation. Enhances infectivity and
CC       symptom expression (By similarity). {ECO:0000250,
CC       ECO:0000269|PubMed:7856079}.
CC   -!- SUBUNIT: Homooligomer. Interacts with the replication-associated
CC       protein (REP). Interacts with host proliferating cell nuclear antigen
CC       (PCNA). Interacts with host retinoblastoma-related protein 1 (RBR1),
CC       and may thereby deregulate the host cell cycle. Oligomerization and
CC       interaction with PCNA are necessary for optimal replication
CC       enhancement.
CC   -!- SIMILARITY: Belongs to the geminiviridae replication enhancer protein
CC       family. {ECO:0000305}.
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DR   EMBL; M24597; AAA42754.1; -; Genomic_DNA.
DR   EMBL; AF379637; AAK59262.1; -; Genomic_DNA.
DR   PIR; S28363; S28363.
DR   Proteomes; UP000006542; Genome.
DR   GO; GO:0039684; P:rolling circle single-stranded viral DNA replication; IDA:UniProtKB.
DR   InterPro; IPR000657; Gemini_AL3.
DR   Pfam; PF01407; Gemini_AL3; 1.
DR   PRINTS; PR00231; GEMCOATAL3.
PE   3: Inferred from homology;
KW   Host-virus interaction; Reference proteome.
FT   CHAIN           1..136
FT                   /note="Replication enhancer"
FT                   /id="PRO_0000222238"
FT   VARIANT         26
FT                   /note="S -> N (in strain: Infectious clone pBCT028)"
FT   VARIANT         120
FT                   /note="N -> T (in strain: Infectious clone pBCT028)"
SQ   SEQUENCE   136 AA;  16063 MW;  6FC079BAB7FCC824 CRC64;
     MNVIEDFRTG EPITLHQATN SVEFESVPNP LYMKLLWFER YGPIYQLKIQ IRFNYNLRRA
     LNLHKCWIEL TITGSNRILT GPRFLKVLKK RLEIYLDNLG LICINNVIRG LNHVLYEEFN
     FVSSVIQNQS VAMNLY