ID   REN_CLVK                Reviewed;         134 AA.
AC   P14977;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Replication enhancer protein;
DE            Short=REn;
DE   AltName: Full=15.9 kDa protein;
DE   AltName: Full=Protein AC3;
DE   AltName: Full=Protein AL3;
GN   ORFNames=AC3, AL3;
OS   African cassava mosaic virus (isolate West Kenyan 844) (ACMV) (Cassava
OS   latent virus (isolate West Kenyan 844)).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Repensiviricetes;
OC   Geplafuvirales; Geminiviridae; Begomovirus.
OX   NCBI_TaxID=10818;
OH   NCBI_TaxID=197394; Hewittia sublobata.
OH   NCBI_TaxID=3996; Jatropha multifida (Coralbush).
OH   NCBI_TaxID=194268; Laportea.
OH   NCBI_TaxID=3983; Manihot esculenta (Cassava) (Jatropha manihot).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Stanley J., Gay M.R.;
RT   "Nucleotide sequence of cassava latent virus DNA.";
RL   Nature 301:260-262(1983).
RN   [2]
RP   FUNCTION.
RX   PubMed=2045787; DOI=10.1099/0022-1317-72-6-1205;
RA   Morris B., Richardson K., Eddy P., Zhan X.C., Haley A., Gardner R.;
RT   "Mutagenesis of the AC3 open reading frame of African cassava mosaic virus
RT   DNA A reduces DNA B replication and ameliorates disease symptoms.";
RL   J. Gen. Virol. 72:1205-1213(1991).
CC   -!- FUNCTION: Increases viral DNA accumulation. Enhances infectivity and
CC       symptom expression. {ECO:0000269|PubMed:2045787}.
CC   -!- SUBUNIT: Homooligomer. Interacts with the replication-associated
CC       protein (REP). Interacts with host proliferating cell nuclear antigen
CC       (PCNA). Interacts with host retinoblastoma-related protein 1 (RBR1),
CC       and may thereby deregulate the host cell cycle. Oligomerization and
CC       interaction with PCNA are necessary for optimal replication enhancement
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the geminiviridae replication enhancer protein
CC       family. {ECO:0000305}.
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DR   EMBL; J02057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Proteomes; UP000008452; Genome.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR000657; Gemini_AL3.
DR   Pfam; PF01407; Gemini_AL3; 1.
DR   PRINTS; PR00231; GEMCOATAL3.
PE   3: Inferred from homology;
KW   Host-virus interaction.
FT   CHAIN           1..134
FT                   /note="Replication enhancer protein"
FT                   /id="PRO_0000222239"
SQ   SEQUENCE   134 AA;  15805 MW;  BFF02966F13AD88E CRC64;
     MDLRTGEVIT APQAMNGVYT WEINNPLYFT ITRHQQRPFL LNQDIITVQV RFNHNLRKEL
     GIHKCFLNFQ IWTTLQPQTG LFLRVFRYQV IKYLDNIGVI SINNVIRAAD HVLFNVIANT
     IECKLTHEIK FNVY