ID   REN_ICMV                Reviewed;         134 AA.
AC   Q08590;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Replication enhancer protein;
DE            Short=REn;
DE   AltName: Full=Protein AC3;
DE   AltName: Full=Protein AL3;
GN   ORFNames=AC3, AL3;
OS   Indian cassava mosaic virus (ICMV).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Repensiviricetes;
OC   Geplafuvirales; Geminiviridae; Begomovirus.
OX   NCBI_TaxID=31600;
OH   NCBI_TaxID=3983; Manihot esculenta (Cassava) (Jatropha manihot).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8245859; DOI=10.1099/0022-1317-74-11-2437;
RA   Hong Y.G., Robinson D.J., Harrison B.D.;
RT   "Nucleotide sequence evidence for the occurrence of three distinct
RT   whitefly-transmitted geminiviruses in cassava.";
RL   J. Gen. Virol. 74:2437-2443(1993).
CC   -!- FUNCTION: Increases viral DNA accumulation. Enhances infectivity and
CC       symptom expression (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. Interacts with the replication-associated
CC       protein (REP). Interacts with host proliferating cell nuclear antigen
CC       (PCNA). Interacts with host retinoblastoma-related protein 1 (RBR1),
CC       and may thereby deregulate the host cell cycle. Oligomerization and
CC       interaction with PCNA are necessary for optimal replication enhancement
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the geminiviridae replication enhancer protein
CC       family. {ECO:0000305}.
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DR   EMBL; Z24758; CAA80888.1; -; Genomic_DNA.
DR   PIR; JQ2329; JQ2329.
DR   RefSeq; NP_047231.1; NC_001932.1.
DR   GeneID; 991058; -.
DR   KEGG; vg:991058; -.
DR   Proteomes; UP000007210; Genome.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR000657; Gemini_AL3.
DR   Pfam; PF01407; Gemini_AL3; 1.
DR   PRINTS; PR00231; GEMCOATAL3.
PE   3: Inferred from homology;
KW   Host-virus interaction; Reference proteome.
FT   CHAIN           1..134
FT                   /note="Replication enhancer protein"
FT                   /id="PRO_0000222241"
SQ   SEQUENCE   134 AA;  15769 MW;  8062E3CA77B80D59 CRC64;
     MDSRTGELIT AAQAMNGVFI WEVPNPLYFK IIQHDNRPFV MNQDIITVQI RFNHNLRKAL
     GLHQCWMDFK VWTTLQPQTW RFLRVFKTQV LKYLDSLGVI SINTIVKAVE HVLYNVIHGT
     DRVEQSNLIK LNIY