ID   REN_PHUV                Reviewed;         132 AA.
AC   Q06925;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Replication enhancer protein;
DE            Short=REn;
DE   AltName: Full=Protein AC3;
DE   AltName: Full=Protein AL3;
GN   ORFNames=AC3, AL3;
OS   Pepper huasteco yellow vein virus (PHYVV) (Pepper huasteco virus).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Repensiviricetes;
OC   Geplafuvirales; Geminiviridae; Begomovirus.
OX   NCBI_TaxID=223303;
OH   NCBI_TaxID=4072; Capsicum annuum (Capsicum pepper).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8409944; DOI=10.1099/0022-1317-74-10-2225;
RA   Torres-Pacheco I., Garzon-Tiznado J.A., Herrera-Estrella L.,
RA   Rivera-Bustamante R.F.;
RT   "Complete nucleotide sequence of pepper huasteco virus: analysis and
RT   comparison with bipartite geminiviruses.";
RL   J. Gen. Virol. 74:2225-2231(1993).
CC   -!- FUNCTION: Increases viral DNA accumulation. Enhances infectivity and
CC       symptom expression (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. Interacts with the replication-associated
CC       protein (REP). Interacts with host proliferating cell nuclear antigen
CC       (PCNA). Interacts with host retinoblastoma-related protein 1 (RBR1),
CC       and may thereby deregulate the host cell cycle. Oligomerization and
CC       interaction with PCNA are necessary for optimal replication enhancement
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the geminiviridae replication enhancer protein
CC       family. {ECO:0000305}.
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DR   EMBL; X70418; CAA49858.1; -; Genomic_DNA.
DR   PIR; JQ2302; JQ2302.
DR   PIR; S31877; S31877.
DR   RefSeq; NP_040322.1; NC_001359.1.
DR   GeneID; 988146; -.
DR   KEGG; vg:988146; -.
DR   Proteomes; UP000002321; Genome.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR000657; Gemini_AL3.
DR   Pfam; PF01407; Gemini_AL3; 1.
DR   PRINTS; PR00231; GEMCOATAL3.
PE   3: Inferred from homology;
KW   Host-virus interaction.
FT   CHAIN           1..132
FT                   /note="Replication enhancer protein"
FT                   /id="PRO_0000222242"
SQ   SEQUENCE   132 AA;  15444 MW;  A3C0BB77277467B7 CRC64;
     MDLRTGVPIT AAQAANGVFI WELRNPLYFK IRLVETPMYT RSRVFHIQVR ANHNMRTALG
     LHKAYFNFQV WTTLTTISGQ IYLNRFKLLV MFYLDNLGLI SVNNVIRAVS FATDKRYVNA
     VLENHEIIYK LY