ID   REN_PYMVV               Reviewed;         132 AA.
AC   P27264;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Replication enhancer protein;
DE            Short=REn;
DE   AltName: Full=Protein AC3;
DE   AltName: Full=Protein AL3;
GN   ORFNames=AC3, AL3;
OS   Potato yellow mosaic virus (isolate Venezuela) (PYMV).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Repensiviricetes;
OC   Geplafuvirales; Geminiviridae; Begomovirus.
OX   NCBI_TaxID=223310;
OH   NCBI_TaxID=4113; Solanum tuberosum (Potato).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1856690; DOI=10.1099/0022-1317-72-7-1515;
RA   Coutts R.H.A., Coffin R.S., Roberts E.J.F., Hamilton W.D.O.;
RT   "The nucleotide sequence of the infectious cloned DNA components of potato
RT   yellow mosaic virus.";
RL   J. Gen. Virol. 72:1515-1520(1991).
RN   [2]
RP   FUNCTION.
RX   PubMed=9049382; DOI=10.1099/0022-1317-76-7-1773;
RA   Sung Y.K., Coutts R.H.;
RT   "Mutational analysis of potato yellow mosaic geminivirus.";
RL   J. Gen. Virol. 76:1773-1780(1995).
CC   -!- FUNCTION: Increases viral DNA accumulation. Enhances infectivity and
CC       symptom expression. {ECO:0000269|PubMed:9049382}.
CC   -!- SUBUNIT: Homooligomer. Interacts with the replication-associated
CC       protein (REP). Interacts with host proliferating cell nuclear antigen
CC       (PCNA). Interacts with host retinoblastoma-related protein 1 (RBR1),
CC       and may thereby deregulate the host cell cycle. Oligomerization and
CC       interaction with PCNA are necessary for optimal replication enhancement
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the geminiviridae replication enhancer protein
CC       family. {ECO:0000305}.
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DR   EMBL; D00940; BAA00780.1; -; Genomic_DNA.
DR   PIR; JU0366; QQCVP3.
DR   RefSeq; NP_047239.1; NC_001934.1.
DR   GeneID; 956389; -.
DR   KEGG; vg:956389; -.
DR   Proteomes; UP000006828; Genome.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR000657; Gemini_AL3.
DR   Pfam; PF01407; Gemini_AL3; 1.
DR   PRINTS; PR00231; GEMCOATAL3.
PE   3: Inferred from homology;
KW   Host-virus interaction.
FT   CHAIN           1..132
FT                   /note="Replication enhancer protein"
FT                   /id="PRO_0000222243"
SQ   SEQUENCE   132 AA;  15784 MW;  5AF902DB0A1AF3CE CRC64;
     MDSRTGELIT ARQAENGVFI WEIENPLYFK INQVEDMQYT RTRIYSVQIR FNHNLRRALD
     LHKAYLNFQV WTTSMTASGS NYLARFRQLV LLYLDRLGVI SINNVIRSVR FATDRSYVNY
     VLENHSIKYK FY