ID   REN_SLCV                Reviewed;         134 AA.
AC   P29049;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Replication enhancer protein;
DE            Short=REn;
DE   AltName: Full=Protein AC3;
DE   AltName: Full=Protein AL3;
GN   ORFNames=AC3, AL3;
OS   Squash leaf curl virus (SLCV).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Repensiviricetes;
OC   Geplafuvirales; Geminiviridae; Begomovirus.
OX   NCBI_TaxID=10829;
OH   NCBI_TaxID=3662; Cucurbita moschata (Winter crookneck squash) (Cucurbita pepo var. moschata).
OH   NCBI_TaxID=3663; Cucurbita pepo (Vegetable marrow) (Summer squash).
OH   NCBI_TaxID=3885; Phaseolus vulgaris (Kidney bean) (French bean).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1984668; DOI=10.1016/0042-6822(91)90009-z;
RA   Lazarowitz S.G., Lazdins I.B.;
RT   "Infectivity and complete nucleotide sequence of the cloned genomic
RT   components of a bipartite squash leaf curl geminivirus with a broad host
RT   range phenotype.";
RL   Virology 180:58-69(1991).
CC   -!- FUNCTION: Increases viral DNA accumulation. Enhances infectivity and
CC       symptom expression (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. Interacts with the replication-associated
CC       protein (REP). Interacts with host proliferating cell nuclear antigen
CC       (PCNA). Interacts with host retinoblastoma-related protein 1 (RBR1),
CC       and may thereby deregulate the host cell cycle. Oligomerization and
CC       interaction with PCNA are necessary for optimal replication enhancement
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the geminiviridae replication enhancer protein
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC32412.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; M38183; AAC32412.1; ALT_INIT; Genomic_DNA.
DR   PIR; E36785; QQCVS3.
DR   RefSeq; NP_047245.1; NC_001936.1.
DR   GeneID; 956396; -.
DR   KEGG; vg:956396; -.
DR   Proteomes; UP000009151; Genome.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR000657; Gemini_AL3.
DR   Pfam; PF01407; Gemini_AL3; 1.
DR   PRINTS; PR00231; GEMCOATAL3.
PE   3: Inferred from homology;
KW   Host-virus interaction; Reference proteome.
FT   CHAIN           1..134
FT                   /note="Replication enhancer protein"
FT                   /id="PRO_0000222244"
SQ   SEQUENCE   134 AA;  16232 MW;  D9237EBD99512226 CRC64;
     MVMDLRTWDD ITVHQAENSV FIWEVPNPLY FKMYXVEDPL YTHTRIYHIQ IRFNHNLRRA
     LNLHKAFLNF QVWTESIRAS GTTYLNRFRH LVMLYLDRLG VIGLNNVIRA VSWATDRSYV
     NYVLENHEIK FKIY