ID   REN_TLCVA               Reviewed;         134 AA.
AC   P36281;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   23-FEB-2022, entry version 63.
DE   RecName: Full=Replication enhancer protein;
DE            Short=REn;
DE   AltName: Full=Protein C3;
DE   AltName: Full=Protein L3;
GN   ORFNames=C3, L3;
OS   Tomato leaf curl virus (strain Australia) (ToLCV).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Repensiviricetes;
OC   Geplafuvirales; Geminiviridae; Begomovirus.
OX   NCBI_TaxID=223353;
OH   NCBI_TaxID=185024; Cynanchum acutum.
OH   NCBI_TaxID=145753; Malva parviflora (Little mallow) (Cheeseweed mallow).
OH   NCBI_TaxID=4081; Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8423446; DOI=10.1099/0022-1317-74-1-147;
RA   Dry I.B., Rigden J.E., Krake L.R., Mullineaux P.M., Rezaian M.A.;
RT   "Nucleotide sequence and genome organization of tomato leaf curl
RT   geminivirus.";
RL   J. Gen. Virol. 74:147-151(1993).
CC   -!- FUNCTION: Increases viral DNA accumulation. Enhances infectivity and
CC       symptom expression (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. Interacts with the replication-associated
CC       protein (REP). Interacts with host proliferating cell nuclear antigen
CC       (PCNA). Interacts with host retinoblastoma-related protein 1 (RBR1),
CC       and may thereby deregulate the host cell cycle. Oligomerization and
CC       interaction with PCNA are necessary for optimal replication enhancement
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the geminiviridae replication enhancer protein
CC       family. {ECO:0000305}.
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DR   EMBL; S53251; AAM33779.1; -; Genomic_DNA.
DR   PIR; JQ1889; JQ1889.
DR   RefSeq; NP_632004.1; NC_003896.1.
DR   GeneID; 944502; -.
DR   KEGG; vg:944502; -.
DR   Proteomes; UP000008246; Genome.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR000657; Gemini_AL3.
DR   Pfam; PF01407; Gemini_AL3; 1.
DR   PRINTS; PR00231; GEMCOATAL3.
PE   3: Inferred from homology;
KW   Host-virus interaction.
FT   CHAIN           1..134
FT                   /note="Replication enhancer protein"
FT                   /id="PRO_0000222248"
SQ   SEQUENCE   134 AA;  16114 MW;  26E547DE398BDC70 CRC64;
     MDSRTGEPIT ARQAMNGEYI WRVPNPLYFK IIKHHKRPFN YNHDIIQVRI QFNHNLRRAL
     AIHKCFLDFT VFTRLQPATW RFLRVFKTQV MKYLDSLGVI SINNVIRSVD HVLYNVLDST
     FDVIEDHDIK FNFY