ID   REN_TMOV                Reviewed;         132 AA.
AC   Q06659;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   23-FEB-2022, entry version 61.
DE   RecName: Full=Replication enhancer protein;
DE            Short=REn;
DE   AltName: Full=Protein AC3;
DE   AltName: Full=Protein AL3;
GN   ORFNames=AC3, AL3;
OS   Tomato mottle virus (isolate Florida) (ToMoV).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Repensiviricetes;
OC   Geplafuvirales; Geminiviridae; Begomovirus.
OX   NCBI_TaxID=223359;
OH   NCBI_TaxID=4097; Nicotiana tabacum (Common tobacco).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1469361; DOI=10.1099/0022-1317-73-12-3225;
RA   Abouzid A.M., Polston J.E., Hiebert E.;
RT   "The nucleotide sequence of tomato mottle virus, a new geminivirus isolated
RT   from tomatoes in Florida.";
RL   J. Gen. Virol. 73:3225-3229(1992).
CC   -!- FUNCTION: Increases viral DNA accumulation. Enhances infectivity and
CC       symptom expression (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. Interacts with the replication-associated
CC       protein (REP). Interacts with host proliferating cell nuclear antigen
CC       (PCNA). Interacts with host retinoblastoma-related protein 1 (RBR1),
CC       and may thereby deregulate the host cell cycle. Oligomerization and
CC       interaction with PCNA are necessary for optimal replication enhancement
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the geminiviridae replication enhancer protein
CC       family. {ECO:0000305}.
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DR   EMBL; L14460; AAC32416.1; -; Genomic_DNA.
DR   PIR; JQ1872; JQ1872.
DR   RefSeq; NP_047251.1; NC_001938.1.
DR   GeneID; 956411; -.
DR   KEGG; vg:956411; -.
DR   Proteomes; UP000008249; Genome.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR000657; Gemini_AL3.
DR   Pfam; PF01407; Gemini_AL3; 1.
DR   PRINTS; PR00231; GEMCOATAL3.
PE   3: Inferred from homology;
KW   Host-virus interaction; Reference proteome.
FT   CHAIN           1..132
FT                   /note="Replication enhancer protein"
FT                   /id="PRO_0000222246"
SQ   SEQUENCE   132 AA;  15777 MW;  4C791FAB759D1859 CRC64;
     MDSRTGELIT AHQAENGVYI WELENPLYFK IHRVEDPLYT RTRVYHVQIR FNHNLRKALH
     LHKAYLNFQV WTTSMTASGS IYLARFRYLV NMYLDQLGVI SINNVVRAVR FATNRVYVNH
     VLENHSIKFK FY