ID   REN_TPCTV               Reviewed;         134 AA.
AC   Q88890;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   29-SEP-2021, entry version 51.
DE   RecName: Full=Replication enhancer protein;
DE            Short=REn;
DE   AltName: Full=16.1 kDa protein;
DE   AltName: Full=Protein C3;
DE   AltName: Full=Protein L3;
GN   ORFNames=C3, L3;
OS   Tomato pseudo-curly top virus (TPCTV).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Repensiviricetes;
OC   Geplafuvirales; Geminiviridae; Topocuvirus.
OX   NCBI_TaxID=49267;
OH   NCBI_TaxID=4081; Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OH   NCBI_TaxID=4112; Solanum nigrum (Black nightshade).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8638404; DOI=10.1006/viro.1996.0264;
RA   Briddon R.W., Bedford I.D., Tsai J.H., Markham P.G.;
RT   "Analysis of the nucleotide sequence of the treehopper-transmitted
RT   geminivirus, tomato pseudo-curly top virus, suggests a recombinant
RT   origin.";
RL   Virology 219:387-394(1996).
CC   -!- FUNCTION: Increases viral DNA accumulation. Enhances infectivity and
CC       symptom expression (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. Interacts with the replication-associated
CC       protein (REP). Interacts with host proliferating cell nuclear antigen
CC       (PCNA). Interacts with host retinoblastoma-related protein 1 (RBR1),
CC       and may thereby deregulate the host cell cycle. Oligomerization and
CC       interaction with PCNA are necessary for optimal replication enhancement
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the geminiviridae replication enhancer protein
CC       family. {ECO:0000305}.
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DR   EMBL; X84735; CAA59225.1; -; Genomic_DNA.
DR   RefSeq; NP_620733.1; NC_003825.1.
DR   GeneID; 944409; -.
DR   KEGG; vg:944409; -.
DR   Proteomes; UP000007068; Genome.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR000657; Gemini_AL3.
DR   Pfam; PF01407; Gemini_AL3; 1.
DR   PRINTS; PR00231; GEMCOATAL3.
PE   3: Inferred from homology;
KW   Host-virus interaction; Reference proteome.
FT   CHAIN           1..134
FT                   /note="Replication enhancer protein"
FT                   /id="PRO_0000323685"
SQ   SEQUENCE   134 AA;  15680 MW;  63F663856BB0727D CRC64;
     MDSRTGELLT YTQCQTGCYF DDIKNPIYFR LQNTTTMATG NKIITLQIRA NHNLRKVLGL
     QICWLNLVVL SVSPRLSGEA LLDRFKFHVM KHLNNLGVIS INNVIRSINH FIDLFDQRVF
     YAPSFYYNIK MRLY