ID   REN_TYCS1               Reviewed;         134 AA.
AC   P38611;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   29-SEP-2021, entry version 56.
DE   RecName: Full=Replication enhancer protein;
DE            Short=REn;
DE   AltName: Full=Protein C3;
DE   AltName: Full=Protein L3;
GN   ORFNames=C3, L3;
OS   Tomato yellow leaf curl Sardinia virus (isolate Spain-1) (TYLCSV).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Repensiviricetes;
OC   Geplafuvirales; Geminiviridae; Begomovirus.
OX   NCBI_TaxID=37139;
OH   NCBI_TaxID=185024; Cynanchum acutum.
OH   NCBI_TaxID=4081; Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OH   NCBI_TaxID=4112; Solanum nigrum (Black nightshade).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8198442; DOI=10.1007/bf01309774;
RA   Noris E., Hidalgo E., Accotto G.P., Moriones E.;
RT   "High similarity among the tomato yellow leaf curl virus isolates from the
RT   west Mediterranean basin: the nucleotide sequence of an infectious clone
RT   from Spain.";
RL   Arch. Virol. 135:165-170(1994).
CC   -!- FUNCTION: Increases viral DNA accumulation. Enhances infectivity and
CC       symptom expression (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. Interacts with the replication-associated
CC       protein (REP). Interacts with host proliferating cell nuclear antigen
CC       (PCNA). Interacts with host retinoblastoma-related protein 1 (RBR1),
CC       and may thereby deregulate the host cell cycle. Oligomerization and
CC       interaction with PCNA are necessary for optimal replication enhancement
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the geminiviridae replication enhancer protein
CC       family. {ECO:0000305}.
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DR   EMBL; Z25751; CAA81028.1; -; Genomic_DNA.
DR   PIR; S39213; S39213.
DR   Proteomes; UP000008265; Genome.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR000657; Gemini_AL3.
DR   Pfam; PF01407; Gemini_AL3; 1.
DR   PRINTS; PR00231; GEMCOATAL3.
PE   3: Inferred from homology;
KW   Host-virus interaction.
FT   CHAIN           1..134
FT                   /note="Replication enhancer protein"
FT                   /id="PRO_0000222250"
SQ   SEQUENCE   134 AA;  16066 MW;  6F15DB891ED901B6 CRC64;
     MDLRTGEYIT AHQATSGVYT FEITNPLYFT ITRHNQQPFN SKYNFLTFQI RFNHNLRKAL
     GIHKCFLNFR IWTTLQSPTG HFLRVFRYQV YKYLNNIGVI SLNNVIRAVD YVLFDVFENT
     IDVIEQHEIK YNLY