ID   REN_TYCS2               Reviewed;         134 AA.
AC   Q67618;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Replication enhancer protein;
DE            Short=REn;
DE   AltName: Full=Protein C3;
DE   AltName: Full=Protein L3;
GN   ORFNames=C3, L3;
OS   Tomato yellow leaf curl Sardinia virus (isolate Spain-2) (TYLCSV).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Repensiviricetes;
OC   Geplafuvirales; Geminiviridae; Begomovirus.
OX   NCBI_TaxID=221538;
OH   NCBI_TaxID=4081; Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Reina J., Cuadrado-Gomez I.M., Jimenez J., Bejarano E.R.;
RT   "Characterization of a tomato yellow leaf curl virus isolated from
RT   southeast Spain (almeria).";
RL   Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Increases viral DNA accumulation. Enhances infectivity and
CC       symptom expression (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. Interacts with the replication-associated
CC       protein (REP). Interacts with host proliferating cell nuclear antigen
CC       (PCNA). Interacts with host retinoblastoma-related protein 1 (RBR1),
CC       and may thereby deregulate the host cell cycle. Oligomerization and
CC       interaction with PCNA are necessary for optimal replication enhancement
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the geminiviridae replication enhancer protein
CC       family. {ECO:0000305}.
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DR   EMBL; L27708; AAA47953.1; -; Genomic_DNA.
DR   Proteomes; UP000008266; Genome.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR000657; Gemini_AL3.
DR   Pfam; PF01407; Gemini_AL3; 1.
DR   PRINTS; PR00231; GEMCOATAL3.
PE   3: Inferred from homology;
KW   Host-virus interaction; Reference proteome.
FT   CHAIN           1..134
FT                   /note="Replication enhancer protein"
FT                   /id="PRO_0000323684"
SQ   SEQUENCE   134 AA;  16016 MW;  82BEA183BE731234 CRC64;
     MDLRTGEYIT AHQATSGVYT FEITNPLYFT ITRHNQQPFN SKYNLLTFQI RFNHNLRKAL
     GIHKCFLNFR IWTTLQSPTG HFLRVFRFQV YKYLNNIGVI SLNNVIRAVD YVLFDVFENT
     IDVIEQHEIK YNLY