ID   REN_TYCSV               Reviewed;         134 AA.
AC   P27266;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Replication enhancer protein;
DE            Short=REn;
DE   AltName: Full=Protein C3;
DE   AltName: Full=Protein L3;
GN   ORFNames=C3, L3;
OS   Tomato yellow leaf curl Sardinia virus (TYLCSV).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Repensiviricetes;
OC   Geplafuvirales; Geminiviridae; Begomovirus.
OX   NCBI_TaxID=123735;
OH   NCBI_TaxID=4072; Capsicum annuum (Capsicum pepper).
OH   NCBI_TaxID=185024; Cynanchum acutum.
OH   NCBI_TaxID=145753; Malva parviflora (Little mallow) (Cheeseweed mallow).
OH   NCBI_TaxID=29728; Sinapis arvensis (Charlock mustard) (Brassica kaber).
OH   NCBI_TaxID=4081; Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OH   NCBI_TaxID=4112; Solanum nigrum (Black nightshade).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1840676; DOI=10.1093/nar/19.24.6763;
RA   Kheyr-Pour A., Bendahmane M., Matzeit V., Accotto G.P., Crespi S.,
RA   Gronenborn B.;
RT   "Tomato yellow leaf curl virus from Sardinia is a whitefly-transmitted
RT   monopartite geminivirus.";
RL   Nucleic Acids Res. 19:6763-6769(1991).
RN   [2]
RP   INTERACTION WITH SOLANUM LYCOPERSICUM PCNA.
RX   PubMed=12919743; DOI=10.1016/s0042-6822(03)00234-4;
RA   Castillo A.G., Collinet D., Deret S., Kashoggi A., Bejarano E.R.;
RT   "Dual interaction of plant PCNA with geminivirus replication accessory
RT   protein (Ren) and viral replication protein (Rep).";
RL   Virology 312:381-394(2003).
CC   -!- FUNCTION: Increases viral DNA accumulation. Enhances infectivity and
CC       symptom expression (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. Interacts with the replication-associated
CC       protein (REP). Interacts with host proliferating cell nuclear antigen
CC       (PCNA). Interacts with host retinoblastoma-related protein 1 (RBR1),
CC       and may thereby deregulate the host cell cycle. Oligomerization and
CC       interaction with PCNA are necessary for optimal replication enhancement
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the geminiviridae replication enhancer protein
CC       family. {ECO:0000305}.
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DR   EMBL; X61153; CAA43463.1; -; Genomic_DNA.
DR   PIR; S22590; S22590.
DR   RefSeq; NP_620739.1; NC_003828.1.
DR   GeneID; 944422; -.
DR   KEGG; vg:944422; -.
DR   Proteomes; UP000002323; Genome.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR000657; Gemini_AL3.
DR   Pfam; PF01407; Gemini_AL3; 1.
DR   PRINTS; PR00231; GEMCOATAL3.
PE   1: Evidence at protein level;
KW   Host-virus interaction; Reference proteome.
FT   CHAIN           1..134
FT                   /note="Replication enhancer protein"
FT                   /id="PRO_0000222249"
SQ   SEQUENCE   134 AA;  15954 MW;  3EFB4B4521A60D6F CRC64;
     MDLRTGEYIT AHQATSGVYT FGITNPLYFT ITRHNQNPFN NKYNTLTFQI RFNHNLRKEL
     GIHKCFLNFH IWTTLQSPTG HFLRVFKYQV CKYLNNLGVI SLNNVVRAVD YVLFHVFERT
     IDVTENHEIK FNFY