ID   REN_TYLCC               Reviewed;         134 AA.
AC   Q9DXE7;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   29-SEP-2021, entry version 45.
DE   RecName: Full=Replication enhancer protein;
DE            Short=REn;
DE   AltName: Full=Protein C3;
DE   AltName: Full=Protein L3;
GN   ORFNames=C3, L3;
OS   Tomato yellow leaf curl China virus (TYLCCNV).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Repensiviricetes;
OC   Geplafuvirales; Geminiviridae; Begomovirus.
OX   NCBI_TaxID=185793;
OH   NCBI_TaxID=4097; Nicotiana tabacum (Common tobacco).
OH   NCBI_TaxID=185191; Sigesbeckia orientalis.
OH   NCBI_TaxID=4081; Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate CHI;
RX   PubMed=11682126; DOI=10.1016/s0168-1702(01)00363-x;
RA   Yin Q., Yang H., Gong Q., Wang H., Liu Y., Hong Y., Tien P.;
RT   "Tomato yellow leaf curl China virus: monopartite genome organization and
RT   agroinfection of plants.";
RL   Virus Res. 81:69-76(2001).
CC   -!- FUNCTION: Increases viral DNA accumulation. Enhances infectivity and
CC       symptom expression (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. Interacts with the replication-associated
CC       protein (REP). Interacts with host proliferating cell nuclear antigen
CC       (PCNA). Interacts with host retinoblastoma-related protein 1 (RBR1),
CC       and may thereby deregulate the host cell cycle. Oligomerization and
CC       interaction with PCNA are necessary for optimal replication enhancement
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the geminiviridae replication enhancer protein
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF311734; AAG27473.1; -; Genomic_DNA.
DR   RefSeq; NP_660166.1; NC_004044.1.
DR   GeneID; 949224; -.
DR   KEGG; vg:949224; -.
DR   Proteomes; UP000008267; Genome.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR000657; Gemini_AL3.
DR   Pfam; PF01407; Gemini_AL3; 1.
DR   PRINTS; PR00231; GEMCOATAL3.
PE   3: Inferred from homology;
KW   Host-virus interaction; Reference proteome.
FT   CHAIN           1..134
FT                   /note="Replication enhancer protein"
FT                   /id="PRO_0000312154"
SQ   SEQUENCE   134 AA;  15969 MW;  34FE619A5B02DEE5 CRC64;
     MDSRTGELLT AAQSENGVYI WTVKNPLYFK ITKHHERPFL RNHDIITIQV QFNYNLRKAL
     GIHKCFLTCQ IWTRLHPQTS HFLRVFKYQF IKYLDRLGVI SINNCIRAFS HVLYDVLNGT
     IDVIEKHDIK FNIY