ID   REP11_ECOLX             Reviewed;         325 AA.
AC   Q52347;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=RepFIB replication protein A;
GN   Name=repA;
OS   Escherichia coli.
OG   Plasmid IncFI R386.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8356112; DOI=10.1006/plas.1993.1020;
RA   Gibbs M.D., Spiers A.J., Bergquist P.L.;
RT   "RepFIB: a basic replicon of large plasmids.";
RL   Plasmid 29:165-179(1993).
CC   -!- FUNCTION: This protein is essential for plasmid replication; it is
CC       involved in copy control functions. In vitro, binds to the DNA repeat
CC       units, BCDD'D'', EFG and HIJ (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the initiator RepB protein family.
CC       {ECO:0000305}.
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DR   EMBL; L01254; AAA71884.1; -; Unassigned_DNA.
DR   AlphaFoldDB; Q52347; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006276; P:plasmid maintenance; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000525; Initiator_Rep_prot.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF01051; Rep_3; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; Plasmid; Plasmid copy control.
FT   CHAIN           1..325
FT                   /note="RepFIB replication protein A"
FT                   /id="PRO_0000068305"
FT   REGION          279..298
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   325 AA;  37215 MW;  3C1EC7EC5EBC0870 CRC64;
     MDKSSGELVT LTPNNNNTVQ PVALMRLGVF VPTLKSLKNS KKNTLSRTDA TEELTRLSLA
     RAEGFDKVEI TGPRLDMDND FKTWVGIIHS FARHNVIGDK VELPFVEFAK LCGIPSSQSS
     RSLRERISPS LKRIAGTVIS FSRTDEKHTR EYITHLVQSA YYDTERDIVQ LQADPRLFEL
     YQFDRKVLLQ LKAINALKRR ESAQALYTFI ESLPRDPAPI SLARLRARLN LKSPVFSQNQ
     TVRRAMEQLR EIGYLDYTEI QRGRTKFFCI HYRRPRLKAP NDESKENPLP PSPAEKVSPE
     MAEKLALLEK LGITLDDLEK LFKSR