REP15_HUMAN
ID REP15_HUMAN Reviewed; 236 AA.
AC Q6BDI9; B2RU16;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 4.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Rab15 effector protein;
GN Name=REP15;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASP-101.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 4-236, FUNCTION, SUBCELLULAR LOCATION,
RP INTERACTION WITH THE GTP-BOUND FORM OF RAB15, AND VARIANT ASP-101.
RX PubMed=16195351; DOI=10.1091/mbc.e05-03-0204;
RA Strick D.J., Elferink L.A.;
RT "Rab15 effector protein: a novel protein for receptor recycling from the
RT endocytic recycling compartment.";
RL Mol. Biol. Cell 16:5699-5709(2005).
CC -!- FUNCTION: Regulates transferrin receptor recycling from the endocytic
CC recycling compartment. {ECO:0000269|PubMed:16195351}.
CC -!- SUBUNIT: Interacts with the GTP-bound form of RAB15.
CC {ECO:0000269|PubMed:16195351}.
CC -!- INTERACTION:
CC Q6BDI9; Q99856: ARID3A; NbExp=3; IntAct=EBI-12048237, EBI-5458244;
CC Q6BDI9; O60447: EVI5; NbExp=3; IntAct=EBI-12048237, EBI-852291;
CC Q6BDI9; P61952: GNG11; NbExp=3; IntAct=EBI-12048237, EBI-720198;
CC Q6BDI9; Q15696: ZRSR2; NbExp=3; IntAct=EBI-12048237, EBI-6657923;
CC Q6BDI9; Q15695: ZRSR2P1; NbExp=5; IntAct=EBI-12048237, EBI-12270264;
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000269|PubMed:16195351}. Note=Colocalizes with RAB11 and RAB15 to
CC the endocytic recycling compartment.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAT76304.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
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DR EMBL; AC009509; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC140921; AAI40922.1; -; mRNA.
DR EMBL; AY662682; AAT76304.1; ALT_SEQ; mRNA.
DR CCDS; CCDS31762.1; -.
DR RefSeq; NP_001025045.2; NM_001029874.2.
DR AlphaFoldDB; Q6BDI9; -.
DR BioGRID; 132467; 25.
DR IntAct; Q6BDI9; 5.
DR STRING; 9606.ENSP00000310335; -.
DR iPTMnet; Q6BDI9; -.
DR PhosphoSitePlus; Q6BDI9; -.
DR BioMuta; REP15; -.
DR DMDM; 317373542; -.
DR jPOST; Q6BDI9; -.
DR MassIVE; Q6BDI9; -.
DR PaxDb; Q6BDI9; -.
DR PeptideAtlas; Q6BDI9; -.
DR PRIDE; Q6BDI9; -.
DR ProteomicsDB; 66218; -.
DR Antibodypedia; 49309; 26 antibodies from 12 providers.
DR DNASU; 387849; -.
DR Ensembl; ENST00000310791.4; ENSP00000310335.2; ENSG00000174236.4.
DR GeneID; 387849; -.
DR KEGG; hsa:387849; -.
DR MANE-Select; ENST00000310791.4; ENSP00000310335.2; NM_001029874.3; NP_001025045.3.
DR UCSC; uc001rig.2; human.
DR CTD; 387849; -.
DR DisGeNET; 387849; -.
DR GeneCards; REP15; -.
DR HGNC; HGNC:33748; REP15.
DR HPA; ENSG00000174236; Group enriched (intestine, stomach).
DR MIM; 610848; gene.
DR neXtProt; NX_Q6BDI9; -.
DR OpenTargets; ENSG00000174236; -.
DR VEuPathDB; HostDB:ENSG00000174236; -.
DR eggNOG; ENOG502QQ95; Eukaryota.
DR GeneTree; ENSGT00390000005178; -.
DR HOGENOM; CLU_103399_0_0_1; -.
DR InParanoid; Q6BDI9; -.
DR OMA; KIQIAVQ; -.
DR OrthoDB; 1032357at2759; -.
DR PhylomeDB; Q6BDI9; -.
DR TreeFam; TF337114; -.
DR PathwayCommons; Q6BDI9; -.
DR SignaLink; Q6BDI9; -.
DR BioGRID-ORCS; 387849; 22 hits in 1064 CRISPR screens.
DR GenomeRNAi; 387849; -.
DR Pharos; Q6BDI9; Tbio.
DR PRO; PR:Q6BDI9; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q6BDI9; protein.
DR Bgee; ENSG00000174236; Expressed in mucosa of transverse colon and 91 other tissues.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0010008; C:endosome membrane; IDA:UniProtKB.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
DR GO; GO:0055037; C:recycling endosome; IDA:UniProtKB.
DR GO; GO:0001881; P:receptor recycling; IMP:UniProtKB.
DR GO; GO:0033572; P:transferrin transport; IDA:UniProtKB.
DR InterPro; IPR027985; Rab15_effector.
DR PANTHER; PTHR36682; PTHR36682; 1.
DR Pfam; PF15208; Rab15_effector; 1.
PE 1: Evidence at protein level;
KW Endosome; Lipoprotein; Membrane; Myristate; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000255"
FT CHAIN 2..236
FT /note="Rab15 effector protein"
FT /id="PRO_0000323587"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000255"
FT VARIANT 101
FT /note="N -> D (in dbSNP:rs929949)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:16195351"
FT /id="VAR_039548"
FT VARIANT 206
FT /note="E -> D (in dbSNP:rs12819160)"
FT /id="VAR_039549"
FT CONFLICT 88
FT /note="L -> P (in Ref. 3; AAT76304)"
FT /evidence="ECO:0000305"
FT CONFLICT 114
FT /note="Q -> R (in Ref. 3; AAT76304)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 236 AA; 26571 MW; BE81DA3B710C25DC CRC64;
MGQKASQQLA LKDSKEVPVV CEVVSEAIVH AAQKLKEYLG FEYPPSKLCP AANTLNEIFL
IHFITFCQEK GVDEWLTTTK MTKHQAFLFG ADWIWTFWGS NKQIKLQLAV QTLQMSSPPP
VESKPCDLSN PESRVEESSW KKSRFDKLEE FCNLIGEDCL GLFIIFGMPG KPKDIRGVVL
DSVKSQMVRS HLPGGKAVAQ FVLETEDCVF IKELLRNCLS KKDGLREVGK VYISIL
