REP15_MOUSE
ID REP15_MOUSE Reviewed; 230 AA.
AC Q9D7T1; Q8R1M9; Q9D7R5;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Rab15 effector protein;
GN Name=Rep15;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Regulates transferrin receptor recycling from the endocytic
CC recycling compartment. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with the GTP-bound form of RAB15. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000250}.
CC Note=Colocalizes with RAB11 and RAB15 to the endocytic recycling
CC compartment. {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB25994.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK008892; BAB25956.1; -; mRNA.
DR EMBL; AK008964; BAB25994.1; ALT_FRAME; mRNA.
DR EMBL; BC024344; AAH24344.1; -; mRNA.
DR CCDS; CCDS20704.1; -.
DR RefSeq; NP_079896.1; NM_025620.2.
DR AlphaFoldDB; Q9D7T1; -.
DR STRING; 10090.ENSMUSP00000037503; -.
DR PhosphoSitePlus; Q9D7T1; -.
DR PaxDb; Q9D7T1; -.
DR PeptideAtlas; Q9D7T1; -.
DR PRIDE; Q9D7T1; -.
DR ProteomicsDB; 255226; -.
DR Antibodypedia; 49309; 26 antibodies from 12 providers.
DR DNASU; 66532; -.
DR Ensembl; ENSMUST00000036194; ENSMUSP00000037503; ENSMUSG00000040121.
DR GeneID; 66532; -.
DR KEGG; mmu:66532; -.
DR UCSC; uc009esr.1; mouse.
DR CTD; 387849; -.
DR MGI; MGI:1913782; Rep15.
DR VEuPathDB; HostDB:ENSMUSG00000040121; -.
DR eggNOG; ENOG502QQ95; Eukaryota.
DR GeneTree; ENSGT00390000005178; -.
DR HOGENOM; CLU_103399_0_0_1; -.
DR InParanoid; Q9D7T1; -.
DR OMA; DECFQNM; -.
DR OrthoDB; 1032357at2759; -.
DR PhylomeDB; Q9D7T1; -.
DR TreeFam; TF337114; -.
DR BioGRID-ORCS; 66532; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q9D7T1; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9D7T1; protein.
DR Bgee; ENSMUSG00000040121; Expressed in colon and 47 other tissues.
DR Genevisible; Q9D7T1; MM.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0010008; C:endosome membrane; ISO:MGI.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
DR GO; GO:0055037; C:recycling endosome; ISO:MGI.
DR GO; GO:0001881; P:receptor recycling; ISO:MGI.
DR GO; GO:0033572; P:transferrin transport; ISO:MGI.
DR InterPro; IPR027985; Rab15_effector.
DR PANTHER; PTHR36682; PTHR36682; 1.
DR Pfam; PF15208; Rab15_effector; 1.
PE 2: Evidence at transcript level;
KW Endosome; Lipoprotein; Membrane; Myristate; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000255"
FT CHAIN 2..230
FT /note="Rab15 effector protein"
FT /id="PRO_0000323588"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000255"
FT CONFLICT 103
FT /note="Q -> E (in Ref. 2; AAH24344)"
FT /evidence="ECO:0000305"
FT CONFLICT 203
FT /note="I -> V (in Ref. 2; AAH24344)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 230 AA; 25854 MW; CEA3C30ABAA718FE CRC64;
MGQKASQQVA PKDSQEVLAM CEVVSAAISH AAQKLKEYLG FEYPLSRLCL AASSLTEVFL
VHFVTFCQER GADEWLTTTK MTKHQAWLFG ADWIWTFWGP DKQIRLQVAV QTLRMASLPL
TDPKSCESRG EESWKKGRFD KLQEFCNLVG EDCLGLFIIF GVPGEPKAIR GVVLESVRNG
MMESQLPGRK AVEQFVLETK DCISIKELLG NCLSKRDGLS DMGRVYIRIL
