ID   REP3A_XENLA             Reviewed;         263 AA.
AC   Q6P418;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Receptor expression-enhancing protein 3-A;
GN   Name=reep3-a; Synonyms=reep3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Microtubule-binding protein required to ensure proper cell
CC       division and nuclear envelope reassembly by sequestering the
CC       endoplasmic reticulum away from chromosomes during mitosis. Probably
CC       acts by clearing the endoplasmic reticulum membrane from metaphase
CC       chromosomes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DP1 family. {ECO:0000305}.
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DR   EMBL; BC063730; AAH63730.1; -; mRNA.
DR   RefSeq; NP_001083678.1; NM_001090209.1.
DR   AlphaFoldDB; Q6P418; -.
DR   DNASU; 399057; -.
DR   GeneID; 399057; -.
DR   KEGG; xla:399057; -.
DR   CTD; 399057; -.
DR   Xenbase; XB-GENE-958750; reep3.L.
DR   OMA; DLTISWF; -.
DR   OrthoDB; 1473891at2759; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 399057; Expressed in intestine and 19 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007084; P:mitotic nuclear membrane reassembly; ISS:UniProtKB.
DR   GO; GO:0006998; P:nuclear envelope organization; ISS:UniProtKB.
DR   InterPro; IPR004345; TB2_DP1_HVA22.
DR   PANTHER; PTHR12300; PTHR12300; 1.
DR   Pfam; PF03134; TB2_DP1_HVA22; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Endoplasmic reticulum; Membrane; Microtubule;
KW   Mitosis; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..263
FT                   /note="Receptor expression-enhancing protein 3-A"
FT                   /id="PRO_0000424021"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          161..228
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          240..263
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        181..195
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   263 AA;  30140 MW;  93C310C2C4055013 CRC64;
     MVSWIICKAV VLVFGMLYPA YFSYKAVRTK NVKEYVRWMM YWIVFALYTV TEAIADLTLS
     WFPLYYELKI AFVVWLLSPY TRGASLLYRK FLHPLLSSKE KEIDDYIVQA KEKGYETMVH
     FGKQGLNLAA NAAVTAAVKG QGAITERLRS FSMHDLTAVQ GDETSENRPF ATFPDGQKKA
     RASVSDSSGF GSLRKDSGDD NTDEDVEVNS EDEVYTQKGL RRSQSMRSVK VIKGRKEIRY
     ASLKHKPKKR PQLYFREDTA HHL