ID   REP3B_XENLA             Reviewed;         252 AA.
AC   Q5HZP8;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=Receptor expression-enhancing protein 3-B;
GN   Name=reep3-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Microtubule-binding protein required to ensure proper cell
CC       division and nuclear envelope reassembly by sequestering the
CC       endoplasmic reticulum away from chromosomes during mitosis. Probably
CC       acts by clearing the endoplasmic reticulum membrane from metaphase
CC       chromosomes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DP1 family. {ECO:0000305}.
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DR   EMBL; BC088933; AAH88933.1; -; mRNA.
DR   RefSeq; NP_001088957.1; NM_001095488.1.
DR   AlphaFoldDB; Q5HZP8; -.
DR   DNASU; 496337; -.
DR   GeneID; 496337; -.
DR   CTD; 496337; -.
DR   Xenbase; XB-GENE-17346898; reep3.S.
DR   OrthoDB; 1473891at2759; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   Bgee; 496337; Expressed in blastula and 19 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007084; P:mitotic nuclear membrane reassembly; ISS:UniProtKB.
DR   GO; GO:0006998; P:nuclear envelope organization; ISS:UniProtKB.
DR   InterPro; IPR004345; TB2_DP1_HVA22.
DR   PANTHER; PTHR12300; PTHR12300; 1.
DR   Pfam; PF03134; TB2_DP1_HVA22; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Endoplasmic reticulum; Membrane; Microtubule;
KW   Mitosis; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..252
FT                   /note="Receptor expression-enhancing protein 3-B"
FT                   /id="PRO_0000424022"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          163..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   252 AA;  28840 MW;  F00B088B4E1B9E9A CRC64;
     MVSGMICKAV VLVFGILYPA YNSYKAVRTK NVKEYVRWMM YWIVFALYTV TETIADLTVS
     WFPLYFELKI AFVVWLLSPY TRGASLLYRK FLHPLLSSKE KEIDDYIVQA KEKGYETMVN
     FGKQGLNLAA NAAVTAAVKS QGAITERLRS FSMHDLTDVQ GDETAETRFF PDGQKKPRAS
     VSDSSGFSSL RKDSGDDRTD EDVEVNSEDE VYSQKGLRRS QSMRSVKVIK GRKEIRYGSL
     KHKPKKRPQL YF