ID   REPA_LACPN              Reviewed;          52 AA.
AC   P20044;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Protein RepA;
GN   Name=repA;
OS   Lactiplantibacillus plantarum (Lactobacillus plantarum).
OG   Plasmid pLB4.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactiplantibacillus.
OX   NCBI_TaxID=1590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NCDO 1088;
RX   PubMed=2695401; DOI=10.1016/0378-1119(89)90491-5;
RA   Bates E.E.M., Gilbert H.J.;
RT   "Characterization of a cryptic plasmid from Lactobacillus plantarum.";
RL   Gene 85:253-258(1989).
CC   -!- FUNCTION: Regulates the plasmid copy number. RepA binds to the repAB
CC       promoter thus controlling the synthesis of the plasmid replication
CC       initiator protein RepB.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the transcriptional regulatory CopG/NikR family.
CC       {ECO:0000305}.
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DR   EMBL; M33531; AAA25253.1; -; Genomic_DNA.
DR   PIR; JQ0180; JQ0180.
DR   RefSeq; WP_068281361.1; NZ_MPLC01000007.1.
DR   AlphaFoldDB; P20044; -.
DR   SMR; P20044; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006276; P:plasmid maintenance; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.1220.10; -; 1.
DR   InterPro; IPR013321; Arc_rbn_hlx_hlx.
DR   InterPro; IPR010985; Ribbon_hlx_hlx.
DR   SUPFAM; SSF47598; SSF47598; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Plasmid; Plasmid copy control; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..52
FT                   /note="Protein RepA"
FT                   /id="PRO_0000139316"
FT   DNA_BIND        20..40
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   52 AA;  5798 MW;  4C36BBFE256EEF56 CRC64;
     MVEVEKKKIT LSIPVETNGK LEELAQKYGM TKSGLVNFLV NQVAEAGTIY RQ