ID   REPA_SALTI              Reviewed;         351 AA.
AC   Q934T6;
DT   10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Replication protein RepA;
GN   Name=repA; OrderedLocusNames=HCM2.0131;
OS   Salmonella typhi.
OG   Plasmid pHCM2.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
CC   -!- FUNCTION: This protein is essential for plasmid replication; it is
CC       involved in copy control functions. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the initiator RepB protein family.
CC       {ECO:0000305}.
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DR   EMBL; AL513384; CAD09998.1; -; Genomic_DNA.
DR   RefSeq; NP_569603.1; NC_003385.1.
DR   RefSeq; WP_001293470.1; NZ_UCTR01000018.1.
DR   AlphaFoldDB; Q934T6; -.
DR   STRING; 220341.16506112; -.
DR   PRIDE; Q934T6; -.
DR   KEGG; sty:HCM2.0131; -.
DR   eggNOG; ENOG502Z8F1; Bacteria.
DR   HOGENOM; CLU_056709_0_0_6; -.
DR   OMA; IHAFAKY; -.
DR   Proteomes; UP000000541; Plasmid pHCM2.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006276; P:plasmid maintenance; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000525; Initiator_Rep_prot.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF01051; Rep_3; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; Plasmid; Plasmid copy control.
FT   CHAIN           1..351
FT                   /note="Replication protein RepA"
FT                   /id="PRO_0000068308"
FT   REGION          295..315
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   351 AA;  39441 MW;  D9F2BB5C360F0C3E CRC64;
     MSENGNKNIA IVEAFSETDK KTGEVVTLVP NTNNTVQPVA LMRLGLFVPT LKSTARGRKG
     QMVSMDASAE LKQLSLAKAE GYEDIRISGV RLDMDNDFKT WVGIIHAFAK HKVVGDTVTL
     PFVEFVRLCG IPTARSSAKL RKRLDSSLTR IATNTISFRS KGSDEYYVTH LVQTAKYSTK
     NDTVSLQADP KIFELYQFDK KVLLQLRAIN ELSRKESAQA LYTFIESLPP DPAPISLARL
     RARLNLTSRT ITQNATVRKA MEQLREIGYL DYTEVKRGSS VYFIIHYRRP KLRPALPPTK
     AAPEEPEDIL PGDDQEDIID VVPEEKEGEM VMLSKEELAI LEELRKAKAR K