ID   REPB_STAAU              Reviewed;         235 AA.
AC   P0A0C3; P05061;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=Replication protein;
GN   Name=repB;
OS   Staphylococcus aureus.
OG   Plasmid pUB110.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3744038;
RA   Bashkirov V.I., Mil'Shina N.V., Prozorov A.A.;
RT   "Nucleotide sequence and physical map of kanamycin-resistant plasmid pUB110
RT   from Staphylococcus aureus.";
RL   Genetika 22:1081-1092(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3007933; DOI=10.1007/bf00330534;
RA   Mueller R.E., Ano T., Imanaka T., Aiba S.;
RT   "Complete nucleotide sequences of Bacillus plasmids pUB110dB, pRBH1 and its
RT   copy mutants.";
RL   Mol. Gen. Genet. 202:169-171(1986).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3010356; DOI=10.1016/0147-619x(86)90046-6;
RA   McKenzie T., Hoshino T., Tanaka T., Sueoka N.;
RT   "The nucleotide sequence of pUB110: some salient features in relation to
RT   replication and its regulation.";
RL   Plasmid 15:93-103(1986).
RN   [4]
RP   SEQUENCE REVISION.
RX   PubMed=3033723; DOI=10.1016/0147-619x(87)90015-1;
RA   McKenzie T., Hoshino T., Tanaka T., Sueoka N.;
RT   "Correction. A revision of the nucleotide sequence and functional map of
RT   pUB110.";
RL   Plasmid 17:83-85(1987).
CC   -!- FUNCTION: Produces a single-strand nick in a specific site of the
CC       plasmid, and this nick results in single-strand replication by rolling
CC       circle mechanism.
CC   -!- SIMILARITY: Belongs to the Gram-positive plasmids replication protein
CC       type 1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA88362.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAA98215.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M37273; AAA98215.1; ALT_INIT; Genomic_DNA.
DR   EMBL; X03408; CAA27141.1; -; Genomic_DNA.
DR   EMBL; M19465; AAA88362.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_040434.1; NC_001384.1.
DR   RefSeq; WP_002328820.1; NZ_RIYL01000017.1.
DR   AlphaFoldDB; P0A0C3; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR000989; Rep.
DR   Pfam; PF01446; Rep_1; 1.
PE   3: Inferred from homology;
KW   DNA replication; Plasmid.
FT   CHAIN           1..235
FT                   /note="Replication protein"
FT                   /id="PRO_0000068317"
FT   BINDING         149
FT                   /ligand="DNA"
FT                   /ligand_id="ChEBI:CHEBI:16991"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   235 AA;  27895 MW;  247C0371D8F6201A CRC64;
     MKHGIQSQKV VAEVIKQKPT VRWLFLTLTV KNVYDGEELN KSLSDMAQGF RRMMQYKKIN
     KNLVGFMRAT EVTINNKDNS YNQHMHVLVC VEPTYFKNTE NYVNQKQWIQ FWKKAMKLDY
     DPNVKVQMIR PKNKYKSDIQ SAIDETAKYP VKDTDFMTDD EEKNLKRLSD LEEGLHRKRL
     ISYGGLLKEI HKKLNLDDTE EGDLIHTDDD EKADEDGFSI IAMWNWERKN YFIKE