ID   REPE2_ECOLX             Reviewed;         251 AA.
AC   P62538; P33456;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Replication initiation protein;
DE            Short=Protein E;
DE            Short=Protein rep;
GN   Name=repE; Synonyms=E, rep;
OS   Escherichia coli.
OG   Plasmid IncHI1 R27.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3288833; DOI=10.1111/j.1365-2958.1988.tb00023.x;
RA   Saul D., Lane D., Bergquist P.L.;
RT   "A replication region of the IncHI plasmid, R27, is highly homologous with
RT   the RepFIA replicon of F.";
RL   Mol. Microbiol. 2:219-225(1988).
CC   -!- SIMILARITY: Belongs to the initiator RepB protein family.
CC       {ECO:0000305}.
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DR   EMBL; Y00547; CAA68616.1; -; Genomic_DNA.
DR   PIR; S03768; QQECR7.
DR   RefSeq; WP_000807689.1; NZ_WVVQ01000029.1.
DR   AlphaFoldDB; P62538; -.
DR   SMR; P62538; -.
DR   DIP; DIP-46188N; -.
DR   OMA; ETHDSEN; -.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006276; P:plasmid maintenance; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR000525; Initiator_Rep_prot.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01051; Rep_3; 1.
DR   SUPFAM; SSF46785; SSF46785; 2.
PE   3: Inferred from homology;
KW   DNA replication; Plasmid; Plasmid copy control.
FT   CHAIN           1..251
FT                   /note="Replication initiation protein"
FT                   /id="PRO_0000068298"
SQ   SEQUENCE   251 AA;  29378 MW;  33DE916FA68178DF CRC64;
     MAEIAVINHK KRKNSPRIVQ SNELTEAAYS LSRDQKRLLY LFVHQIRKSD GSLQEHDGIC
     EIHVAKYAET FGLTSAEASK DIRQALKGFA GKEVVFYRPE EDAGDEKGYE SFPWFIKRAH
     SPSRGLYSVH INPYLIPFFI GLQNRFTQFR LSETKEITNP YAMRLYESLC QYRKPDGSGV
     VSLKIDWIME RYQLPQSYQR MPDFRRRFLK ASVDEINSRT PMRLSYIEKK KGRQTTHIVF
     SFRDITSMTI E