ID   REPL_SHIFL              Reviewed;          24 AA.
AC   P62551; Q9WTA7;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Positive regulator of RepFIC repA1 expression;
DE   AltName: Full=repA1 leader peptide;
GN   Name=repL; Synonyms=tapA; OrderedLocusNames=CP0259;
OS   Shigella flexneri.
OG   Plasmid pWR100, Plasmid pCP301, and Plasmid pINV_F6_M1382.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M90T / Serotype 5a; PLASMID=pWR100;
RX   PubMed=11115111; DOI=10.1046/j.1365-2958.2000.02179.x;
RA   Buchrieser C., Glaser P., Rusniok C., Nedjari H., d'Hauteville H.,
RA   Kunst F., Sansonetti P.J., Parsot C.;
RT   "The virulence plasmid pWR100 and the repertoire of proteins secreted by
RT   the type III secretion apparatus of Shigella flexneri.";
RL   Mol. Microbiol. 38:760-771(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M90T / Serotype 5a; PLASMID=pWR100;
RX   PubMed=11292750; DOI=10.1128/iai.69.5.3271-3285.2001;
RA   Venkatesan M.M., Goldberg M.B., Rose D.J., Grotbeck E.J., Burland V.,
RA   Blattner F.R.;
RT   "Complete DNA sequence and analysis of the large virulence plasmid of
RT   Shigella flexneri.";
RL   Infect. Immun. 69:3271-3285(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a; PLASMID=pCP301;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M1382 / Serotype 6; PLASMID=pINV_F6_M1382;
RX   PubMed=14573649; DOI=10.1128/iai.71.11.6298-6306.2003;
RA   Lan R., Stevenson G., Reeves P.R.;
RT   "Comparison of two major forms of the Shigella virulence plasmid pINV:
RT   positive selection is a major force driving the divergence.";
RL   Infect. Immun. 71:6298-6306(2003).
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DR   EMBL; AL391753; CAC05868.1; -; Genomic_DNA.
DR   EMBL; AF348706; AAK18590.1; -; Genomic_DNA.
DR   EMBL; AF386526; AAL72558.1; -; Genomic_DNA.
DR   EMBL; AY206448; AAP79040.1; -; Genomic_DNA.
DR   RefSeq; NP_085434.1; NC_002698.1.
DR   RefSeq; NP_858392.1; NC_004851.1.
DR   RefSeq; WP_001365705.1; NZ_WPGW01000206.1.
DR   RefSeq; YP_009062550.1; NC_024996.1.
DR   AlphaFoldDB; P62551; -.
DR   STRING; 198214.CP0259; -.
DR   EnsemblBacteria; AAL72558; AAL72558; SF_p0259.
DR   GeneID; 1238261; -.
DR   GeneID; 58462723; -.
DR   KEGG; sfl:CP0259; -.
DR   HOGENOM; CLU_221811_1_0_6; -.
DR   Proteomes; UP000001006; Plasmid pCP301.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR012605; RepA1_leader_peptide_Tap.
DR   Pfam; PF08048; RepA1_leader; 1.
DR   TIGRFAMs; TIGR03475; tap_IncFII_lead; 1.
PE   4: Predicted;
KW   DNA replication; Leader peptide; Plasmid; Reference proteome.
FT   PEPTIDE         1..24
FT                   /note="Positive regulator of RepFIC repA1 expression"
FT                   /id="PRO_0000068344"
SQ   SEQUENCE   24 AA;  2699 MW;  21A17A45FD71D4AF CRC64;
     MPGKVQDFFL CSLLLRIVSA GWCD