ID   REPS_STRPY              Reviewed;         496 AA.
AC   P14752; Q54852;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Protein RepS;
GN   Name=repS;
OS   Streptococcus pyogenes.
OG   Plasmid pSM19035, Plasmid pMD101, and Plasmid pBT233.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1314;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=pSM19035;
RX   PubMed=2690001; DOI=10.1093/nar/17.23.10110;
RA   Brantl S., Nowak A., Behnke D., Alonso J.C.;
RT   "Revision of the nucleotide sequence of the Streptococcus pyogenes plasmid
RT   pSM19035 repS gene.";
RL   Nucleic Acids Res. 17:10110-10110(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=pSM19035;
RA   Sorokin A.V., Khazak V.E.;
RL   (In) Butler L.O., Harwood C., Moseley B.E.B. (eds.);
RL   Genetic transformation and expression, pp.269-281, Intercept, Andover
RL   (1989).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=pBT233;
RX   PubMed=8293991; DOI=10.1016/0378-1119(93)90441-5;
RA   Ceglowski P., Boitsov A., Chai S., Alonso J.C.;
RT   "Analysis of the stabilization system of pSM19035-derived plasmid pBT233 in
RT   Bacillus subtilis.";
RL   Gene 136:1-12(1993).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=pMD101;
RX   PubMed=8093174; DOI=10.1016/0378-1119(94)90319-0;
RA   Ceglowski P., Alonso J.C.;
RT   "Gene organization of the Streptococcus pyogenes plasmid pDB101: sequence
RT   analysis of the orf eta-copS region.";
RL   Gene 145:33-39(1994).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 436-496.
RC   PLASMID=pSM19035;
RX   PubMed=2123523;
RA   Sorokin A.V., Khazak V.E.;
RT   "Expression unit in the region of replication initiation in the
RT   streptococcal plasmid pSM19035.";
RL   Mol. Biol. (Mosk.) 24:993-1000(1990).
CC   -!- FUNCTION: Essential for replication.
CC   -!- CAUTION: PubMed:2690001 sequence revises that published in Ref.2.
CC       {ECO:0000305}.
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DR   EMBL; X16803; CAA34721.1; -; Genomic_DNA.
DR   EMBL; X64695; CAA45928.1; -; Genomic_DNA.
DR   EMBL; X66468; CAA47078.1; -; Genomic_DNA.
DR   EMBL; X61167; CAA43478.1; -; Genomic_DNA.
DR   PIR; S06925; S06925.
DR   RefSeq; WP_011266101.1; NC_006979.1.
DR   RefSeq; YP_232731.1; NC_006978.1.
DR   RefSeq; YP_232752.1; NC_006979.1.
DR   RefSeq; YP_232769.1; NC_006979.1.
DR   AlphaFoldDB; P14752; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR014820; PriCT_1.
DR   Pfam; PF08708; PriCT_1; 1.
PE   4: Predicted;
KW   DNA replication; DNA-binding; Plasmid.
FT   CHAIN           1..496
FT                   /note="Protein RepS"
FT                   /id="PRO_0000068336"
FT   DNA_BIND        120..141
FT                   /evidence="ECO:0000255"
FT   CONFLICT        438
FT                   /note="G -> V (in Ref. 5; CAA43478)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   496 AA;  57373 MW;  269712933C55E010 CRC64;
     MNIPFVVETV LHDGLLKYKF KNSKIRSITT KPGKSKGAIF AYRSKKSMIG GRGVVLTSEE
     AIHENQDTFT HWTPNVYRYG TYADENRSYT KGHSENNLRQ INTFFIDFDI HTEKETISAS
     DILTTAIDLG FMPTLIIKSD KGYQAYFVLE TPVYVTSKSE FKSVKAAKII SQNIREYFGK
     SLPVDLTCNH FGIARIPRTD NVEFFDPNYR YSFKEWQDWS FKQTDNKGFT RSSLMVLSGT
     EGKKQVDEPW FNLLLHETKF SGEKGLVGRN SVMFTLSLAY FSSGYSIETC EYNMFEFNNR
     LDQPLEEKEV IKLVRSAYSE NYQGANREYI TILCKAWVSS DLTSKDLFVR QGWFKFKKKR
     SERQRVHLSE WKEDLMAYIS EKSDVYKPYL VTTKKEIREA LGIPERTLDK LLKVLKANQE
     IFFKIKSGRN GGIQLASGKS LLLSIIKVKK EEKESYIKAL TNSFDLEHTF IQETLNKLAE
     RPKTDTQLDL FSYDTG