ID   REPY_ECOLX              Reviewed;         316 AA.
AC   P22308;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Replication initiation protein;
GN   Name=repA;
OS   Escherichia coli.
OG   Plasmid pSC101.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6579542; DOI=10.1073/pnas.80.21.6557;
RA   Vocke C., Bastia D.;
RT   "Primary structure of the essential replicon of the plasmid pSC101.";
RL   Proc. Natl. Acad. Sci. U.S.A. 80:6557-6561(1983).
CC   -!- SIMILARITY: Belongs to the initiator RepB protein family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB59158.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; K00042; AAB59157.1; -; Genomic_DNA.
DR   EMBL; K00042; AAB59158.1; ALT_INIT; Genomic_DNA.
DR   PIR; A43703; A43703.
DR   RefSeq; WP_001293213.1; NZ_VDIZ01000045.1.
DR   AlphaFoldDB; P22308; -.
DR   SMR; P22308; -.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR000525; Initiator_Rep_prot.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01051; Rep_3; 1.
DR   SUPFAM; SSF46785; SSF46785; 2.
PE   3: Inferred from homology;
KW   DNA replication; Plasmid.
FT   CHAIN           1..316
FT                   /note="Replication initiation protein"
FT                   /id="PRO_0000068341"
SQ   SEQUENCE   316 AA;  37355 MW;  0D2365BA6572C121 CRC64;
     MSELVVFKAN ELAISRYDLT EHETKLILCC VALLNPTIEN PTRKERTVSF TYNQYAQMMN
     ISRENAYGVL AKATRELMTR TVEIRNPLVK GFEIFQWTNY AKFSSEKLEL VFSEEILPYL
     FQLKKFIKYN LEHVKSFENK YSMRIYEWLL KELTQKKTHK ANIEISLDEF KFMLMLENNY
     HEFKRLNQWV LKPISKDLNT YSNMKLVVDK RGRPTDTLIF QVELDRQMDL VTELENNQIK
     MNGDKIPTTI TSDSYLHNGL RKTLHDALTA KIQLTSFEAK FLSDMQSKYD LNGSFSWLTQ
     KQRTTLENIL AKYGRI