ID   REPZ_ECOLX              Reviewed;         343 AA.
AC   P18023;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Replication initiation protein;
DE   AltName: Full=Replication-associated protein;
GN   Name=repZ;
OS   Escherichia coli.
OG   Plasmid IncI1 ColIb-P9.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1690704; DOI=10.1128/jb.172.4.1983-1991.1990;
RA   Hama C., Takizawa T., Moriwaki H., Urasaki Y., Mizobuchi K.;
RT   "Organization of the replication control region of plasmid ColIb-P9.";
RL   J. Bacteriol. 172:1983-1991(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9.
RX   PubMed=2191957; DOI=10.1016/s0021-9258(18)86998-8;
RA   Hama C., Takizawa T., Moriwaki H., Mizobuchi K.;
RT   "Role of leader peptide synthesis in repZ gene expression of the ColIb-P9
RT   plasmid.";
RL   J. Biol. Chem. 265:10666-10673(1990).
CC   -!- FUNCTION: Probably functions as an initiator for the IncI1 ColIb-P9
CC       replicon.
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DR   EMBL; M34837; AAA23191.1; -; Genomic_DNA.
DR   PIR; A35152; A35152.
DR   RefSeq; WP_000907863.1; NZ_VKUQ01000038.1.
DR   RefSeq; YP_009061303.1; NC_024977.1.
DR   AlphaFoldDB; P18023; -.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0006276; P:plasmid maintenance; IEA:InterPro.
DR   InterPro; IPR003446; Plasmid_replication_init_RepA.
DR   Pfam; PF02387; IncFII_repA; 1.
PE   4: Predicted;
KW   DNA replication; Plasmid.
FT   CHAIN           1..343
FT                   /note="Replication initiation protein"
FT                   /id="PRO_0000068340"
FT   REGION          42..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   343 AA;  40510 MW;  9C89EEBBAF2A676E CRC64;
     MAGLKNTPYN AVHWSQLAPE EQIRFWEDYE AGRATTFLVE PERKRTKRRR GEHSTKPKCE
     NPSWYRPERY KALKGQLGHA YNRLVKKDPV TGEQSLRMRM SRHPFYVQKR TFVGRKYAFR
     PEKQRLLDAI WPVLVSFSDA GTHTVGMSVT RLAEEISPKD SEGHVIPELE VTVSRLSRLL
     AEQVRFGVLG VSEETMWDRE HRQRLPRYVW ITPAGWQMLG VDMVKLHEQQ QKRLRESEIR
     QQLIREGVLR EDEDISVHAA RKRWYLQRSQ DALKKRREKA AASKRANRLK KLPVDQQIYE
     MAEYLRKRLP PDEAYFCSDD HLKRLAIREL RQLELTLAAP PPH