ID   REP_BPHC1               Reviewed;         775 AA.
AC   P51711;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   07-OCT-2020, entry version 79.
DE   RecName: Full=Replication protein;
DE            EC=3.1.-.-;
GN   Name=rep;
OS   Haemophilus phage HP1 (strain HP1c1) (Bacteriophage HP1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Myoviridae; Peduovirinae; Hpunavirus.
OX   NCBI_TaxID=1289570;
OH   NCBI_TaxID=727; Haemophilus influenzae.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8710508; DOI=10.1093/nar/24.12.2360;
RA   Esposito D., Fitzmaurice W.P., Benjamin R.C., Goodman S.D., Waldman A.S.,
RA   Scocca J.J.;
RT   "The complete nucleotide sequence of bacteriophage HP1 DNA.";
RL   Nucleic Acids Res. 24:2360-2368(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-258.
RX   PubMed=7997180; DOI=10.1111/j.1365-2958.1994.tb00462.x;
RA   Esposito D., Scocca J.J.;
RT   "Identification of an HP1 phage protein required for site-specific
RT   excision.";
RL   Mol. Microbiol. 13:685-695(1994).
CC   -!- FUNCTION: Possible endonuclease which induces a single-strand cut and
CC       initiates DNA replication.
CC   -!- SIMILARITY: Belongs to the phage GPA family. {ECO:0000305}.
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DR   EMBL; U24159; AAB09194.1; -; Genomic_DNA.
DR   PIR; S69515; S69515.
DR   RefSeq; NP_043478.1; NC_001697.1.
DR   PRIDE; P51711; -.
DR   GeneID; 1261121; -.
DR   KEGG; vg:1261121; -.
DR   Proteomes; UP000001713; Genome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   InterPro; IPR008766; Replication_gene_A.
DR   Pfam; PF05840; Phage_GPA; 1.
PE   3: Inferred from homology;
KW   DNA replication; Endonuclease; Hydrolase; Nuclease; Reference proteome;
KW   Viral DNA replication.
FT   CHAIN           1..775
FT                   /note="Replication protein"
FT                   /id="PRO_0000165306"
FT   ACT_SITE        512
FT                   /note="O-(5'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        516
FT                   /note="O-(5'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   775 AA;  90416 MW;  0E55FFD0F8B8F792 CRC64;
     MQSMWEQQRN NNLTAKNAHM AVVACERYQA AENGHKFDRT LLPFDESCYT PLQLELFATN
     PVDFEFIEQK LENLPRQRQR EYFRKLYLKA YRSVKDDGSI AFLLGNKQRR HANDYLRDIL
     DVRLQKVFSQ YNVNVDFLQA FINTPQWLLS VKDEMQQAVQ FSTVPTREEL AKHYNELHYS
     GFHFRLLGTQ QKQKQLPFYL ITESKLKKMA YEMATAFIRF QCDCSHFLKN GIEKDNEGDI
     QGYFYQLYKW CGEIAFSAGF KIPHWEKIEN DKRIKAEHID STLIRLTCEK WWFKQMRDIQ
     KRMVEHIAIA CGEVRANAAS YISNQSFQEW QLQQRKNHDY LRAMIIENID NPEEQVELFD
     MFLKSSSNPA LRRNEMMVRL RGLEEWAEEN NNEALFLTLT APSSFHAGNG NKKWLGVNPR
     ETQNYLNKVW QQFRALLSKR NIKFYGMRVA EPHKDGTPHW HALAYVPAEH KEEVIRLFKQ
     KALELDGNEK GAAEHRCKVE KCDKTKGSAT AYIAKYIAKN IDGFALAGEV SDEDPTLSLH
     DNALRVRAWA SRWGIRQFQF YGGASICVWR ELRRLISGQA DDEIINKAQA AAGIANDYAA
     YMEIQGGALA KRADQPIKLD YETKPANKYG EQRKAIIGLA NRFSLKQVIS RTKKWQIKKR
     PQDFAQRTES MVERSSTANN SARSAPWTCV SNCNRSILEQ KIKLLTQPIC APLSAQKLDY
     LFKYKRLTID KYTALELTEN DVQLVKRNQN MMTSLSPVSR NFQKLKDFHK NQRIQ