ID   REQUA_XENLA             Reviewed;         388 AA.
AC   Q9W638; Q9PWJ6;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Zinc finger protein ubi-d4 A;
DE   AltName: Full=Apoptosis response zinc finger protein A;
DE   AltName: Full=Protein requiem A;
DE            Short=xReq A;
GN   Name=req-a; Synonyms=req1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RX   PubMed=10209271; DOI=10.1016/s0167-4781(99)00031-7;
RA   Konishi M., Hiraoka Y., Ogawa M., Sakai Y., Ishii H., Aiso S.;
RT   "Molecular cloning and expression of Xenopus laevis Requiem cDNA.";
RL   Biochim. Biophys. Acta 1445:172-176(1999).
CC   -!- FUNCTION: May be a transcription factor required for the apoptosis
CC       response following survival factor withdrawal from myeloid cells. Might
CC       also have a role in the development and maturation of lymphoid cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the requiem/DPF family. {ECO:0000305}.
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DR   EMBL; AB021741; BAA77574.1; -; mRNA.
DR   EMBL; AB021737; BAA77570.1; -; mRNA.
DR   RefSeq; NP_001079117.1; NM_001085648.1.
DR   RefSeq; XP_018111885.1; XM_018256396.1.
DR   AlphaFoldDB; Q9W638; -.
DR   SMR; Q9W638; -.
DR   GeneID; 373651; -.
DR   KEGG; xla:373651; -.
DR   CTD; 373651; -.
DR   Xenbase; XB-GENE-945342; dpf2.L.
DR   OMA; GPXRILE; -.
DR   OrthoDB; 708781at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 373651; Expressed in blastula and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR025750; DPF1-3_N.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF00628; PHD; 1.
DR   Pfam; PF14051; Requiem_N; 1.
DR   SMART; SM00249; PHD; 2.
DR   SMART; SM00355; ZnF_C2H2; 1.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   SUPFAM; SSF57903; SSF57903; 2.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..388
FT                   /note="Zinc finger protein ubi-d4 A"
FT                   /id="PRO_0000168152"
FT   ZN_FING         205..228
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         269..329
FT                   /note="PHD-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT   ZN_FING         326..376
FT                   /note="PHD-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT   REGION          60..190
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          233..264
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        121..141
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        244..261
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        339..340
FT                   /note="Missing (in Ref. 1; BAA77570)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   388 AA;  43907 MW;  49788CAFBBE08558 CRC64;
     MAAAVEKILG EQYYKDAMEQ CHNYNARLCA ERSVRLPFLD SQTRVAQSNC YIWMEKRHRG
     PGSAPGQLYT YPSRRWRKKR RAHPPEDPRL SFPSLKPDPE QMLKKEGVIP PDGSSLEALL
     RSDPIEKRIM PDSRDDDSLT EFPPLSRSAR KRILEPDDFL DDLDDEDYEE DTPKKRGKGK
     AKGKGIGSAR KKLDAAALDD RDKPYACDIC GKRYKNRPGL SYHYAHSHLV DEEGAGAEDK
     EDSQPPTPIM HRPEEQKSKK GPDGIALPNN YCDFCLGDSK INKKTNQSEE LVSCSDCGRS
     GHPSCLQFTA VMMAAVKTYR WQCIECKCCN ICGTSENDDQ LLFCDDCDRG YHMYCLVPPV
     AEPPEGSWSC HLCLDLLKDK ASIYQNQS