ID   REQUB_XENLA             Reviewed;         366 AA.
AC   Q9W636; Q9PWJ7; Q9W637;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   26-SEP-2001, sequence version 2.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Zinc finger protein ubi-d4 B;
DE   AltName: Full=Apoptosis response zinc finger protein B;
DE   AltName: Full=Protein requiem B;
DE            Short=xReq B;
DE   Flags: Fragment;
GN   Name=req-b; Synonyms=req2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RX   PubMed=10209271; DOI=10.1016/s0167-4781(99)00031-7;
RA   Konishi M., Hiraoka Y., Ogawa M., Sakai Y., Ishii H., Aiso S.;
RT   "Molecular cloning and expression of Xenopus laevis Requiem cDNA.";
RL   Biochim. Biophys. Acta 1445:172-176(1999).
CC   -!- FUNCTION: May be a transcription factor required for the apoptosis
CC       response following survival factor withdrawal from myeloid cells. Might
CC       also have a role in the development and maturation of lymphoid cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the requiem/DPF family. {ECO:0000305}.
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DR   EMBL; AB021738; BAA77571.1; -; mRNA.
DR   EMBL; AB021740; BAA77573.1; -; mRNA.
DR   EMBL; AB021739; BAA77572.1; -; mRNA.
DR   AlphaFoldDB; Q9W636; -.
DR   SMR; Q9W636; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR025750; DPF1-3_N.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF00628; PHD; 1.
DR   Pfam; PF14051; Requiem_N; 1.
DR   SMART; SM00249; PHD; 2.
DR   SMART; SM00355; ZnF_C2H2; 1.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   SUPFAM; SSF57903; SSF57903; 2.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           <1..366
FT                   /note="Zinc finger protein ubi-d4 B"
FT                   /id="PRO_0000168153"
FT   ZN_FING         183..206
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         247..307
FT                   /note="PHD-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT   ZN_FING         304..354
FT                   /note="PHD-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT   REGION          41..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          140..167
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          211..243
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        222..239
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        174
FT                   /note="A -> S (in Ref. 1; BAA77573)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        317..366
FT                   /note="DQLLFCDDCDRGYHMYCLSPPVAEPPEGSWSCHLCLDLLKDKASIYQKQS
FT                   -> CSELPVSVGSVAVL (in Ref. 1; BAA77572)"
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
SQ   SEQUENCE   366 AA;  41453 MW;  F3763A6F5C392D2D CRC64;
     HNYNARLCAE RSVRMPFLDS QTGVAQSNCY IWMEKRHRGQ ASAPGQLYTY PSRRWRKKRR
     AHPPEDPRLS FPSLKPDPEQ MLKKEGLIPP DGSSLEALLR SDPIEKRIIP DPRDDDSLTE
     FPTLSRSARK RILEPDDFLD DLDDEDYEED TPKRRKGKSK GKGIGGARKK LDAAALDDRD
     KPYACDICGK RYKNRPGLSY HYAHSHLVDE EGAGAEDKED SQPPTPIMHR SEEQKSKKGP
     DGLALPNNYC DFCLGDSNTN KKSNQPEELV SCSDCGRSGH PSCLQFTPVM MAAVKTYRWQ
     CIECKCCNIC GTSENDDQLL FCDDCDRGYH MYCLSPPVAE PPEGSWSCHL CLDLLKDKAS
     IYQKQS