ID   REQU_CHICK              Reviewed;         405 AA.
AC   P58268;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   26-SEP-2001, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Zinc finger protein ubi-d4;
DE   AltName: Full=Apoptosis response zinc finger protein;
DE   AltName: Full=Protein requiem;
GN   Name=REQ;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Ninkina N.N., Kulikova D.A., Mertsalov I.B., Buchman V.L.;
RL   Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be a transcription factor required for the apoptosis
CC       response following survival factor withdrawal from myeloid cells. Might
CC       also have a role in the development and maturation of lymphoid cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the requiem/DPF family. {ECO:0000305}.
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DR   EMBL; AF362751; AAK51965.1; -; mRNA.
DR   RefSeq; NP_989662.1; NM_204331.1.
DR   AlphaFoldDB; P58268; -.
DR   SMR; P58268; -.
DR   STRING; 9031.ENSGALP00000017805; -.
DR   PaxDb; P58268; -.
DR   GeneID; 374236; -.
DR   KEGG; gga:374236; -.
DR   CTD; 5977; -.
DR   VEuPathDB; HostDB:geneid_374236; -.
DR   eggNOG; KOG1244; Eukaryota.
DR   InParanoid; P58268; -.
DR   OrthoDB; 708781at2759; -.
DR   PhylomeDB; P58268; -.
DR   PRO; PR:P58268; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0071565; C:nBAF complex; IBA:GO_Central.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR025750; DPF1-3_N.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF00628; PHD; 1.
DR   Pfam; PF14051; Requiem_N; 1.
DR   SMART; SM00249; PHD; 2.
DR   SUPFAM; SSF57903; SSF57903; 2.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 2.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..405
FT                   /note="Zinc finger protein ubi-d4"
FT                   /id="PRO_0000168151"
FT   ZN_FING         209..246
FT                   /note="C2H2-type; atypical"
FT   ZN_FING         284..344
FT                   /note="PHD-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT   ZN_FING         341..391
FT                   /note="PHD-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT   REGION          80..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          165..194
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          210..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          248..280
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        124..142
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   405 AA;  45884 MW;  A25E44DCA8738A57 CRC64;
     MAAVVQNVVK LLGEQYYRDA MEQCHNYNAR LCAERSVRLP FLDSQTGVAQ SNCYIWMEKR
     HRGPGLAAGQ LYSYPARRWR KKRRAHPPED PRLSFPSIKP DTDQTLKKEG LISQDGSSLE
     ALLRTDPLEK RSLPDPRMDD DSLGEFPVTN SRARKRILEP DDFLDDLDDE DYEEDTPKRR
     GKGKAKGKGV GGARKKLDAA ILEDRDKPYA CDNSYKQKHS LKPPDRVCGK RYKNRPGLSY
     HYAHSHLAEE EGDDKDDSQP PTPVSQRSEE QKSKKGPDGL ALPNNYCDFC LGDSKINKKT
     GQPEELVSCS DCGRSGHPSC LQFTPVMMAA VKTYRWQCIE CKCCNICGTS ENDDQLLFCD
     DCDRGYHMYC LTPPMSEPPE GSWSCHLCLD LLKEKASIYQ NQNNS