RER3_ARATH
ID RER3_ARATH Reviewed; 337 AA.
AC Q9C9Z2;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Protein RETICULATA-RELATED 3, chloroplastic {ECO:0000303|PubMed:23596191};
DE Flags: Precursor;
GN Name=RER3 {ECO:0000303|PubMed:23596191};
GN OrderedLocusNames=At3g08640 {ECO:0000312|Araport:AT3G08640};
GN ORFNames=F17O14.11 {ECO:0000312|EMBL:AAG51347.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP GENE FAMILY, NOMENCLATURE, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF GLY-129
RP AND GLY-228.
RX PubMed=23596191; DOI=10.1104/pp.113.217323;
RA Perez-Perez J.M., Esteve-Bruna D., Gonzalez-Bayon R., Kangasjarvi S.,
RA Caldana C., Hannah M.A., Willmitzer L., Ponce M.R., Micol J.L.;
RT "Functional redundancy and divergence within the Arabidopsis RETICULATA-
RT RELATED gene family.";
RL Plant Physiol. 162:589-603(2013).
CC -!- FUNCTION: May play a role in leaf development. Required for leaf
CC mesophyll cell division in the early stages of leaf organogenesis.
CC {ECO:0000305|PubMed:23596191}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast membrane
CC {ECO:0000305|PubMed:23596191}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in root meristem, root vasculature,
CC distal region of young leaf primordia, leaf bundle sheath cells,
CC hydathodes and pollen grains. {ECO:0000269|PubMed:23596191}.
CC -!- DEVELOPMENTAL STAGE: During embryo development, expressed from the
CC heart stage onwards and restricted to the adaxial side of the
CC cotyledons in mature embryos. {ECO:0000269|PubMed:23596191}.
CC -!- DISRUPTION PHENOTYPE: Defects in embryo development, seedling
CC germination and early growth. Pale interveinal phenotype due to marked
CC reduction in the density of mesophyll cells in interveinal regions of
CC leaves. {ECO:0000269|PubMed:23596191}.
CC -!- SIMILARITY: Belongs to the RETICULATA family. {ECO:0000305}.
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DR EMBL; AC012562; AAG51347.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74657.1; -; Genomic_DNA.
DR EMBL; AY081327; AAL91216.1; -; mRNA.
DR EMBL; AY128826; AAM91226.1; -; mRNA.
DR RefSeq; NP_187476.1; NM_111698.4.
DR AlphaFoldDB; Q9C9Z2; -.
DR STRING; 3702.AT3G08640.1; -.
DR iPTMnet; Q9C9Z2; -.
DR PaxDb; Q9C9Z2; -.
DR PRIDE; Q9C9Z2; -.
DR ProteomicsDB; 234669; -.
DR EnsemblPlants; AT3G08640.1; AT3G08640.1; AT3G08640.
DR GeneID; 820011; -.
DR Gramene; AT3G08640.1; AT3G08640.1; AT3G08640.
DR KEGG; ath:AT3G08640; -.
DR Araport; AT3G08640; -.
DR TAIR; locus:2077838; AT3G08640.
DR eggNOG; ENOG502QRRA; Eukaryota.
DR HOGENOM; CLU_036961_0_0_1; -.
DR InParanoid; Q9C9Z2; -.
DR OMA; CVNNVLG; -.
DR OrthoDB; 1065362at2759; -.
DR PhylomeDB; Q9C9Z2; -.
DR PRO; PR:Q9C9Z2; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9C9Z2; baseline and differential.
DR Genevisible; Q9C9Z2; AT.
DR GO; GO:0009507; C:chloroplast; IDA:TAIR.
DR GO; GO:0009941; C:chloroplast envelope; HDA:TAIR.
DR GO; GO:0031969; C:chloroplast membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; HDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009536; C:plastid; HDA:TAIR.
DR GO; GO:0009793; P:embryo development ending in seed dormancy; IMP:TAIR.
DR GO; GO:0048366; P:leaf development; IMP:TAIR.
DR GO; GO:0009648; P:photoperiodism; IMP:TAIR.
DR GO; GO:0000302; P:response to reactive oxygen species; IMP:TAIR.
DR InterPro; IPR021825; RETICULATA-related.
DR Pfam; PF11891; RETICULATA-like; 1.
PE 1: Evidence at protein level;
KW Chloroplast; Developmental protein; Membrane; Plastid; Reference proteome;
KW Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..59
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 60..337
FT /note="Protein RETICULATA-RELATED 3, chloroplastic"
FT /evidence="ECO:0000255"
FT /id="PRO_0000433442"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 70..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 129
FT /note="G->E: In rer3-1; pale interveinal phenotype."
FT /evidence="ECO:0000269|PubMed:23596191"
FT MUTAGEN 228
FT /note="G->S: In rer3-2; pale interveinal phenotype."
FT /evidence="ECO:0000269|PubMed:23596191"
SQ SEQUENCE 337 AA; 35252 MW; 5B593228C8E6C3F9 CRC64;
MAAMAAKLQL SAKSDQSSVR LPRVINLSRD PTTRVSFPRN GSVCSLHTNF SSPHLAKPCA
GGGGGGSTGN NGGGSGSGGG GGGFGGSGGE ASEESSPWGP IGLFIQGWRS RVAADPQFPF
KVLMEEIVGL SACVLGDMAS RPNFGLNELD FVFSTLVVGS ILNFVLMYML APTAATLGSS
QTLPGIFRNC PSSHMFEQGS FTVMNRFGTL VYKGMVFASV GLAAGLVGTA ISNGLIMLRK
KMDPSFETPN KPPPTVLNSL TWATHMGVSA NARYQTLNGI EFLLAKVLPP LVFKTSVIVL
RCANNVAGGM SFVLLARMTG SQSVEEKTEI SEKEKDD
