RER4_ARATH
ID RER4_ARATH Reviewed; 386 AA.
AC Q94CJ5; Q67YD5;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Protein RETICULATA-RELATED 4, chloroplastic {ECO:0000303|PubMed:23596191};
DE Flags: Precursor;
GN Name=RER4 {ECO:0000303|PubMed:23596191};
GN OrderedLocusNames=At5g12470 {ECO:0000312|Araport:AT5G12470};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, GENE FAMILY, NOMENCLATURE, AND DISRUPTION PHENOTYPE.
RX PubMed=23596191; DOI=10.1104/pp.113.217323;
RA Perez-Perez J.M., Esteve-Bruna D., Gonzalez-Bayon R., Kangasjarvi S.,
RA Caldana C., Hannah M.A., Willmitzer L., Ponce M.R., Micol J.L.;
RT "Functional redundancy and divergence within the Arabidopsis RETICULATA-
RT RELATED gene family.";
RL Plant Physiol. 162:589-603(2013).
CC -!- FUNCTION: May play a role in leaf development.
CC {ECO:0000305|PubMed:23596191}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast membrane
CC {ECO:0000250|UniProtKB:Q9C9Z2}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Pale interveinal phenotype due to marked
CC reduction in the density of mesophyll cells in interveinal regions of
CC leaves. {ECO:0000269|PubMed:23596191}.
CC -!- SIMILARITY: Belongs to the RETICULATA family. {ECO:0000305}.
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DR EMBL; AL592312; CAC42908.1; -; Genomic_DNA.
DR EMBL; CP002688; AED91814.1; -; Genomic_DNA.
DR EMBL; AY091130; AAM14079.1; -; mRNA.
DR EMBL; AY114001; AAM45049.1; -; mRNA.
DR EMBL; BT002454; AAO00814.1; -; mRNA.
DR EMBL; BT008470; AAP37829.1; -; mRNA.
DR EMBL; AK176209; BAD43972.1; -; mRNA.
DR EMBL; AK176533; BAD44296.1; -; mRNA.
DR RefSeq; NP_568280.1; NM_121285.4.
DR AlphaFoldDB; Q94CJ5; -.
DR STRING; 3702.AT5G12470.1; -.
DR PaxDb; Q94CJ5; -.
DR PRIDE; Q94CJ5; -.
DR ProteomicsDB; 234725; -.
DR EnsemblPlants; AT5G12470.1; AT5G12470.1; AT5G12470.
DR GeneID; 831122; -.
DR Gramene; AT5G12470.1; AT5G12470.1; AT5G12470.
DR KEGG; ath:AT5G12470; -.
DR Araport; AT5G12470; -.
DR TAIR; locus:505006615; AT5G12470.
DR eggNOG; ENOG502QQX6; Eukaryota.
DR HOGENOM; CLU_036961_2_1_1; -.
DR InParanoid; Q94CJ5; -.
DR OMA; KSPLMAW; -.
DR OrthoDB; 877919at2759; -.
DR PhylomeDB; Q94CJ5; -.
DR PRO; PR:Q94CJ5; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q94CJ5; baseline and differential.
DR Genevisible; Q94CJ5; AT.
DR GO; GO:0009507; C:chloroplast; HDA:TAIR.
DR GO; GO:0009941; C:chloroplast envelope; HDA:TAIR.
DR GO; GO:0009706; C:chloroplast inner membrane; HDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009536; C:plastid; HDA:TAIR.
DR InterPro; IPR021825; RETICULATA-related.
DR Pfam; PF11891; RETICULATA-like; 1.
PE 2: Evidence at transcript level;
KW Chloroplast; Developmental protein; Membrane; Plastid; Reference proteome;
KW Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..61
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 62..386
FT /note="Protein RETICULATA-RELATED 4, chloroplastic"
FT /evidence="ECO:0000255"
FT /id="PRO_0000433443"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 61..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 335
FT /note="A -> D (in Ref. 4; BAD44296)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 386 AA; 41323 MW; AE0DE308C407FACE CRC64;
MAIASCFFCV PTPNTAISES NLTWPHIASF PRLSSSSSFN GVISAKSISF NRRVPITPVL
SASSGNGGSD NNGGGLSGGG GGGDGGKNDG DGHGDEDRDR NRNEAMLLLK ESGIELESLP
KDLAAAIEAG RIPGSVITRF LELQKSAVMR WLMQFGGFRE RLLADDLFMA KLAMECGVGI
FTKTAAEYER RRENFFNELE VVFADVAMAI IADFMLVYLP APTVSLRPPL ALTAGGISKF
FHNCPDNAFQ VALSGTSYTL LQRLGAITRN GAKLFAVGTT SSLVGTAITN AFIKARKAVD
QNSEGEVETV PIVSTSVAYG VYMAVSSNLR YQIVAGVIEQ RLLEPMLHQH KLALSALCFA
VRTGNTFLGS LLWVDYARLI GIQKSH
