ID   RERGL_BOVIN             Reviewed;         204 AA.
AC   A6QP66;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Ras-related and estrogen-regulated growth inhibitor-like protein;
DE            EC=3.6.5.2 {ECO:0000250|UniProtKB:Q96A58};
DE   AltName: Full=RERG/Ras-like protein;
GN   Name=RERGL;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds GDP/GTP and may possess intrinsic GTPase activity.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC         Evidence={ECO:0000250|UniProtKB:Q96A58};
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC       {ECO:0000305}.
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DR   EMBL; BC149174; AAI49175.1; -; mRNA.
DR   RefSeq; NP_001098942.1; NM_001105472.1.
DR   AlphaFoldDB; A6QP66; -.
DR   SMR; A6QP66; -.
DR   STRING; 9913.ENSBTAP00000040628; -.
DR   PaxDb; A6QP66; -.
DR   Ensembl; ENSBTAT00000043032; ENSBTAP00000040628; ENSBTAG00000030493.
DR   GeneID; 100125833; -.
DR   KEGG; bta:100125833; -.
DR   CTD; 79785; -.
DR   VEuPathDB; HostDB:ENSBTAG00000030493; -.
DR   VGNC; VGNC:33874; RERGL.
DR   eggNOG; KOG0395; Eukaryota.
DR   GeneTree; ENSGT00940000161146; -.
DR   HOGENOM; CLU_041217_9_7_1; -.
DR   InParanoid; A6QP66; -.
DR   OMA; QEVALMF; -.
DR   OrthoDB; 1384728at2759; -.
DR   TreeFam; TF318030; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000030493; Expressed in ureter and 93 other tissues.
DR   GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF00071; Ras; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51421; RAS; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..204
FT                   /note="Ras-related and estrogen-regulated growth inhibitor-
FT                   like protein"
FT                   /id="PRO_0000320562"
FT   REGION          1..204
FT                   /note="Small GTPase-like"
FT   BINDING         10..17
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         57..63
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         122..125
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   204 AA;  23371 MW;  A9AF5047DA5133E7 CRC64;
     MNDVKLTVLG GEGTGKSALI VRFLTKRFIG EYASNFESIY NKHLCLEGKQ LNLEIYDPCS
     QPQKAKFSLT SELHWADGFV IVYDISDRSS FAFAKALIYR IREPQTSHCK RPVESAVLLV
     GNKQDLCHVR EVGWEEGHKL ALDNRCQFCE LSAAEQSLEV EMMFIRIIRD ILTNFKLKEK
     RRYSGSKSMA KLINNVFGKR RKSV