ID   RERGL_DANRE             Reviewed;         205 AA.
AC   Q6DGN0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Ras-related and estrogen-regulated growth inhibitor-like protein;
DE            EC=3.6.5.2 {ECO:0000250|UniProtKB:Q96A58};
DE   AltName: Full=RERG/Ras-like protein;
GN   Name=rergl; ORFNames=zgc:92849;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds GDP/GTP and may possess intrinsic GTPase activity.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC         Evidence={ECO:0000250|UniProtKB:Q96A58};
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC       {ECO:0000305}.
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DR   EMBL; BC076311; AAH76311.1; -; mRNA.
DR   RefSeq; NP_001002494.1; NM_001002494.1.
DR   AlphaFoldDB; Q6DGN0; -.
DR   SMR; Q6DGN0; -.
DR   STRING; 7955.ENSDARP00000016722; -.
DR   PaxDb; Q6DGN0; -.
DR   GeneID; 436767; -.
DR   KEGG; dre:436767; -.
DR   CTD; 436767; -.
DR   ZFIN; ZDB-GENE-040718-198; rergla.
DR   eggNOG; KOG0395; Eukaryota.
DR   InParanoid; Q6DGN0; -.
DR   OrthoDB; 1384728at2759; -.
DR   PhylomeDB; Q6DGN0; -.
DR   PRO; PR:Q6DGN0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF00071; Ras; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51421; RAS; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..205
FT                   /note="Ras-related and estrogen-regulated growth inhibitor-
FT                   like protein"
FT                   /id="PRO_0000320564"
FT   REGION          1..205
FT                   /note="Small GTPase-like"
FT   BINDING         10..17
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         57..63
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         122..125
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   205 AA;  23225 MW;  A36B41E09B4EDB77 CRC64;
     MNDIKVAVLG SEGVGKSALI VRFLTRRFIG EYASSSECIY RKRMSIDARQ LNLELHDPCS
     QPCDGKSTLN EQIHWADGFV VVYDISDRSS FLTAKAIVHL IRELHLGATK RDSDSVIFLV
     GNKQDLCHMR EVDREEGQKL ASESRCQFYE LSAAEHYQEV LLMFSKIVRN ASLGSKAKER
     RRRPSGSKSM AKLINNVFGK RRKSV