ID   RERG_BOVIN              Reviewed;         199 AA.
AC   Q0VCJ7;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Ras-related and estrogen-regulated growth inhibitor;
DE            EC=3.6.5.2 {ECO:0000250|UniProtKB:Q96A58};
GN   Name=RERG;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds GDP/GTP and possesses intrinsic GTPase activity. Has
CC       higher affinity for GDP than for GTP (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC         Evidence={ECO:0000250|UniProtKB:Q96A58};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC       {ECO:0000305}.
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DR   EMBL; BC120134; AAI20135.1; -; mRNA.
DR   RefSeq; NP_001069666.1; NM_001076198.2.
DR   AlphaFoldDB; Q0VCJ7; -.
DR   SMR; Q0VCJ7; -.
DR   STRING; 9913.ENSBTAP00000002817; -.
DR   PaxDb; Q0VCJ7; -.
DR   Ensembl; ENSBTAT00000002817; ENSBTAP00000002817; ENSBTAG00000002174.
DR   Ensembl; ENSBTAT00000068017; ENSBTAP00000073486; ENSBTAG00000002174.
DR   GeneID; 540025; -.
DR   KEGG; bta:540025; -.
DR   CTD; 85004; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002174; -.
DR   VGNC; VGNC:33873; RERG.
DR   eggNOG; KOG0395; Eukaryota.
DR   GeneTree; ENSGT00940000159750; -.
DR   HOGENOM; CLU_041217_9_7_1; -.
DR   InParanoid; Q0VCJ7; -.
DR   OMA; TETVQWA; -.
DR   OrthoDB; 1384728at2759; -.
DR   TreeFam; TF318030; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000002174; Expressed in caput epididymis and 100 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC.
DR   GO; GO:0019003; F:GDP binding; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR   GO; GO:0009725; P:response to hormone; IEA:Ensembl.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR020849; Small_GTPase_Ras-type.
DR   PANTHER; PTHR24070; PTHR24070; 1.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51421; RAS; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTP-binding; Hydrolase; Nucleotide-binding; Proto-oncogene;
KW   Reference proteome.
FT   CHAIN           1..199
FT                   /note="Ras-related and estrogen-regulated growth inhibitor"
FT                   /id="PRO_0000281328"
FT   BINDING         13..20
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         60..64
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         118..121
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   199 AA;  22622 MW;  6DD0DABD840CEFF0 CRC64;
     MAKSAEVKLA IFGRAGVGKS ALVVRFLTKR FIWEYDPTLE STYRHQATID DEVVTMEILD
     TAGQEDTIQR EGHMRWGEGF VLVYDITDRG SFEEVLPLKN ILDEIKKPKN VTLILVGNKA
     DLDHSRQVST EEGEKLATEL ACAFYECSAC TGEGNITEIF YELCREVRRR RMVQGKTRRR
     SSTTHVKQAI NKMLTKISS