ID   RES18_BOVIN             Reviewed;         174 AA.
AC   A0JNL8;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Regulated endocrine-specific protein 18;
DE   Flags: Precursor;
GN   Name=RESP18;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play an important regulatory role in corticotrophs.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:P47940}. Golgi apparatus
CC       {ECO:0000250|UniProtKB:P47940}. Cytoplasmic vesicle, secretory vesicle
CC       lumen {ECO:0000250|UniProtKB:P47940}. Note=Found in the lumen of
CC       secretory vesicles (dense core vesicles, DCV). However, seems to be
CC       retained intracellularly and not secreted.
CC       {ECO:0000250|UniProtKB:P47939, ECO:0000250|UniProtKB:P47940}.
CC   -!- SIMILARITY: Belongs to the RESP18 family. {ECO:0000305}.
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DR   EMBL; BC126772; AAI26773.1; -; mRNA.
DR   RefSeq; NP_001071365.1; NM_001077897.2.
DR   AlphaFoldDB; A0JNL8; -.
DR   STRING; 9913.ENSBTAP00000014474; -.
DR   PaxDb; A0JNL8; -.
DR   Ensembl; ENSBTAT00000014474; ENSBTAP00000014474; ENSBTAG00000010897.
DR   GeneID; 510410; -.
DR   KEGG; bta:510410; -.
DR   CTD; 389075; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010897; -.
DR   VGNC; VGNC:33875; RESP18.
DR   eggNOG; KOG0793; Eukaryota.
DR   GeneTree; ENSGT00390000008124; -.
DR   HOGENOM; CLU_106769_1_0_1; -.
DR   InParanoid; A0JNL8; -.
DR   OMA; KIMRLLW; -.
DR   OrthoDB; 1329808at2759; -.
DR   TreeFam; TF338242; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000010897; Expressed in adenohypophysis and 69 other tissues.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR   InterPro; IPR024833; RESP18.
DR   InterPro; IPR029403; RESP18_dom.
DR   PANTHER; PTHR17314; PTHR17314; 1.
DR   Pfam; PF14948; RESP18; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Endoplasmic reticulum; Golgi apparatus;
KW   Reference proteome; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..174
FT                   /note="Regulated endocrine-specific protein 18"
FT                   /id="PRO_0000336990"
FT   REGION          88..113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   174 AA;  19458 MW;  FE411B92EA4B058C CRC64;
     MQRQLWLGGF RGLWLLVCFL LLNSRLGGSS DVSGHDGQSQ VGVGQLWPLP GFTTPVFKHL
     QVLLQQIMPH DLFWKDDMTQ EVMTQKMGRT SKLHPEDPCV RSGPAAFPTR TPGVRGKQEE
     KLRLLFPKSP MVKVNKDQCF TSKVVSKVLK HEVANPVKGF FESPPTVGHN LVAD