ID   RES18_MOUSE             Reviewed;         175 AA.
AC   P47939;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Regulated endocrine-specific protein 18;
DE   Flags: Precursor;
GN   Name=Resp18;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
RC   TISSUE=Pituitary anterior lobe;
RX   PubMed=7988462; DOI=10.1210/endo.135.6.7988462;
RA   Bloomquist B.T., Darlington D.N., Mueller G.P., Mains R.E., Eipper B.A.;
RT   "Regulated endocrine-specific protein-18: a short-lived novel
RT   glucocorticoid-regulated endocrine protein.";
RL   Endocrinology 135:2714-2722(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Head;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Thymus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   INDUCTION, AND TISSUE SPECIFICITY.
RX   PubMed=17951542; DOI=10.1677/joe-07-0252;
RA   Zhang G., Hirai H., Cai T., Miura J., Yu P., Huang H., Schiller M.R.,
RA   Swaim W.D., Leapman R.D., Notkins A.L.;
RT   "RESP18, a homolog of the luminal domain IA-2, is found in dense core
RT   vesicles in pancreatic islet cells and is induced by high glucose.";
RL   J. Endocrinol. 195:313-321(2007).
CC   -!- FUNCTION: May play an important regulatory role in corticotrophs.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000269|PubMed:7988462}. Golgi apparatus
CC       {ECO:0000250|UniProtKB:P47940}. Cytoplasmic vesicle, secretory vesicle
CC       lumen {ECO:0000250|UniProtKB:P47940}. Note=Found in the lumen of
CC       secretory vesicles (dense core vesicles, DCV) (By similarity). However,
CC       seems to be retained intracellularly and not secreted (PubMed:7988462).
CC       {ECO:0000250|UniProtKB:P47940, ECO:0000269|PubMed:7988462}.
CC   -!- TISSUE SPECIFICITY: Pituitary, hypothalamus and pancreas. Highest
CC       levels are found in somatotrophes, mammotrophes, and gonadotrophes, and
CC       lower levels are found in corticotrophs and thyrotropes.
CC       {ECO:0000269|PubMed:17951542}.
CC   -!- INDUCTION: Up-regulated by high levels of glucose.
CC       {ECO:0000269|PubMed:17951542}.
CC   -!- SIMILARITY: Belongs to the RESP18 family. {ECO:0000305}.
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DR   EMBL; L34214; AAA67425.1; -; mRNA.
DR   EMBL; AK019440; BAB31720.1; -; mRNA.
DR   EMBL; BC027535; AAH27535.1; -; mRNA.
DR   CCDS; CCDS15069.1; -.
DR   PIR; I53285; I53285.
DR   RefSeq; NP_033075.1; NM_009049.2.
DR   AlphaFoldDB; P47939; -.
DR   STRING; 10090.ENSMUSP00000043783; -.
DR   PhosphoSitePlus; P47939; -.
DR   MaxQB; P47939; -.
DR   PaxDb; P47939; -.
DR   PRIDE; P47939; -.
DR   ProteomicsDB; 255228; -.
DR   Antibodypedia; 52248; 7 antibodies from 6 providers.
DR   DNASU; 19711; -.
DR   Ensembl; ENSMUST00000039534; ENSMUSP00000043783; ENSMUSG00000033061.
DR   GeneID; 19711; -.
DR   KEGG; mmu:19711; -.
DR   UCSC; uc007bos.1; mouse.
DR   CTD; 389075; -.
DR   MGI; MGI:1098222; Resp18.
DR   VEuPathDB; HostDB:ENSMUSG00000033061; -.
DR   eggNOG; KOG0793; Eukaryota.
DR   GeneTree; ENSGT00390000008124; -.
DR   HOGENOM; CLU_106769_1_0_1; -.
DR   InParanoid; P47939; -.
DR   OMA; KIMRLLW; -.
DR   OrthoDB; 1329808at2759; -.
DR   PhylomeDB; P47939; -.
DR   TreeFam; TF338242; -.
DR   BioGRID-ORCS; 19711; 4 hits in 71 CRISPR screens.
DR   PRO; PR:P47939; -.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; P47939; protein.
DR   Bgee; ENSMUSG00000033061; Expressed in median eminence of neurohypophysis and 106 other tissues.
DR   ExpressionAtlas; P47939; baseline and differential.
DR   Genevisible; P47939; MM.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043204; C:perikaryon; ISO:MGI.
DR   GO; GO:0048237; C:rough endoplasmic reticulum lumen; ISO:MGI.
DR   GO; GO:0030141; C:secretory granule; ISO:MGI.
DR   GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
DR   InterPro; IPR024833; RESP18.
DR   InterPro; IPR029403; RESP18_dom.
DR   PANTHER; PTHR17314; PTHR17314; 1.
DR   Pfam; PF14948; RESP18; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Endoplasmic reticulum; Golgi apparatus;
KW   Reference proteome; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..175
FT                   /note="Regulated endocrine-specific protein 18"
FT                   /id="PRO_0000022219"
SQ   SEQUENCE   175 AA;  19485 MW;  F0F6AC140BE66816 CRC64;
     MQSSLKPAGS GHLQLLVCFL LLYSRPGSCS DINAHDGQGQ VGSEQLWTFQ GLIASVFQYL
     QLIFHQIVPE GMFWADDIAY ELMTKKVEHL SRLHPQYPCR KDMKAVSPTA NAGVRSKQEE
     KLQLLSPQKS PTVKVNRDRC FTTKVIPKAT KQEATHPTKG FFGPFPTVGL NLVAD