ID   RES18_RAT               Reviewed;         175 AA.
AC   P47940;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Regulated endocrine-specific protein 18;
DE   Flags: Precursor;
GN   Name=Resp18;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=Sprague-Dawley; TISSUE=Pituitary;
RX   PubMed=8132649; DOI=10.1016/s0021-9258(17)37084-9;
RA   Bloomquist B.T., Darlington D.N., Mains R.E., Eipper B.A.;
RT   "RESP18, a novel endocrine secretory protein transcript, and four other
RT   transcripts are regulated in parallel with pro-opiomelanocortin in
RT   melanotropes.";
RL   J. Biol. Chem. 269:9113-9122(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=17951542; DOI=10.1677/joe-07-0252;
RA   Zhang G., Hirai H., Cai T., Miura J., Yu P., Huang H., Schiller M.R.,
RA   Swaim W.D., Leapman R.D., Notkins A.L.;
RT   "RESP18, a homolog of the luminal domain IA-2, is found in dense core
RT   vesicles in pancreatic islet cells and is induced by high glucose.";
RL   J. Endocrinol. 195:313-321(2007).
CC   -!- FUNCTION: May play an important regulatory role in corticotrophs.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000269|PubMed:17951542}. Golgi apparatus
CC       {ECO:0000269|PubMed:17951542}. Cytoplasmic vesicle, secretory vesicle
CC       lumen {ECO:0000269|PubMed:17951542}. Note=Found in the lumen of
CC       secretory vesicles (dense core vesicles, DCV) (PubMed:17951542).
CC       However, seems to be retained intracellularly and not secreted (By
CC       similarity). {ECO:0000250|UniProtKB:P47939,
CC       ECO:0000269|PubMed:17951542}.
CC   -!- TISSUE SPECIFICITY: Pituitary, hypothalamus and pancreas
CC       (PubMed:8132649). Found in alpha, beta and delta cells in the
CC       pancreatic islets (PubMed:17951542). {ECO:0000269|PubMed:17951542,
CC       ECO:0000269|PubMed:8132649}.
CC   -!- SIMILARITY: Belongs to the RESP18 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L25633; AAB59694.1; -; mRNA.
DR   EMBL; BC058147; AAH58147.1; -; mRNA.
DR   PIR; A53523; A53523.
DR   RefSeq; NP_062151.1; NM_019278.1.
DR   AlphaFoldDB; P47940; -.
DR   STRING; 10116.ENSRNOP00000026753; -.
DR   PaxDb; P47940; -.
DR   PRIDE; P47940; -.
DR   GeneID; 50561; -.
DR   KEGG; rno:50561; -.
DR   UCSC; RGD:3555; rat.
DR   CTD; 389075; -.
DR   RGD; 3555; Resp18.
DR   VEuPathDB; HostDB:ENSRNOG00000019704; -.
DR   eggNOG; KOG0793; Eukaryota.
DR   HOGENOM; CLU_106769_1_0_1; -.
DR   InParanoid; P47940; -.
DR   OrthoDB; 1329808at2759; -.
DR   PhylomeDB; P47940; -.
DR   TreeFam; TF338242; -.
DR   PRO; PR:P47940; -.
DR   Proteomes; UP000002494; Chromosome 9.
DR   Bgee; ENSRNOG00000019704; Expressed in cerebellum and 20 other tissues.
DR   ExpressionAtlas; P47940; baseline and differential.
DR   Genevisible; P47940; RN.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:RGD.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043204; C:perikaryon; IDA:RGD.
DR   GO; GO:0048237; C:rough endoplasmic reticulum lumen; IDA:RGD.
DR   GO; GO:0030141; C:secretory granule; IDA:RGD.
DR   GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
DR   InterPro; IPR024833; RESP18.
DR   InterPro; IPR029403; RESP18_dom.
DR   PANTHER; PTHR17314; PTHR17314; 1.
DR   Pfam; PF14948; RESP18; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Endoplasmic reticulum; Golgi apparatus;
KW   Reference proteome; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..175
FT                   /note="Regulated endocrine-specific protein 18"
FT                   /id="PRO_0000022221"
FT   VARIANT         67
FT                   /note="I -> V"
SQ   SEQUENCE   175 AA;  19480 MW;  51FABF35A936F49E CRC64;
     MQSSLKPAGS GVLQLLVCFL LLYSRPSSCS DINAHDGQGQ VGSEQLWTFQ GLVASVFQYL
     QLLFHHIVPQ GMFWTDDIAY ELMTKKVEHL SRLHPQYPCR KEGKVVSPIA TTGVRGKQEE
     KLRLLSPQKS PAVKVNRDRC FTTKVIPKAT KQEVTHPSKG FFGPFPTVGL NLVAD